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Title: Topological state-space estimation of functional human brain networks
We introduce an innovative, data-driven topological data analysis (TDA) technique for estimating the state spaces of dynamically changing functional human brain networks at rest. Our method utilizes the Wasserstein distance to measure topological differences, enabling the clustering of brain networks into distinct topological states. This technique outperforms the commonly used k-means clustering in identifying brain network state spaces by effectively incorporating the temporal dynamics of the data without the need for explicit model specification. We further investigate the genetic underpinnings of these topological features using a twin study design, examining the heritability of such state changes. Our findings suggest that the topology of brain networks, particularly in their dynamic state changes, may hold significant hidden genetic information.  more » « less
Award ID(s):
2010778
PAR ID:
10563244
Author(s) / Creator(s):
; ; ; ;
Editor(s):
Wang, Yalin
Publisher / Repository:
PLOS
Date Published:
Journal Name:
PLOS Computational Biology
Volume:
20
Issue:
5
ISSN:
1553-7358
Page Range / eLocation ID:
e1011869
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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