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1. Microscale Neuronal Activity Collectively Drives Chaotic and Inflexible Dynamics at the Macroscale in Seizures

   https://doi.org/10.1523/JNEUROSCI.0171-22.2023  

   Burrows, Dominic R.; Diana, Giovanni; Pimpel, Birgit; Moeller, Friederike; Richardson, Mark P.; Bassett, Dani S.; Meyer, Martin P.; Rosch, Richard E. (May 2023, The Journal of Neuroscience)

   Neuronal activity propagates through the network during seizures, engaging brain dynamics at multiple scales. Such propagating events can be described through the avalanches framework, which can relate spatiotemporal activity at the microscale with global network properties. Interestingly, propagating avalanches in healthy networks are indicative of critical dynamics, where the network is organized to a phase transition, which optimizes certain computational properties. Some have hypothesized that the pathologic brain dynamics of epileptic seizures are an emergent property of microscale neuronal networks collectively driving the brain away from criticality. Demonstrating this would provide a unifying mechanism linking microscale spatiotemporal activity with emergent brain dysfunction during seizures. Here, we investigated the effect of drug-induced seizures on critical avalanche dynamics, usingin vivowhole-brain two-photon imaging of GCaMP6s larval zebrafish (males and females) at single neuron resolution. We demonstrate that single neuron activity across the whole brain exhibits a loss of critical statistics during seizures, suggesting that microscale activity collectively drives macroscale dynamics away from criticality. We also construct spiking network models at the scale of the larval zebrafish brain, to demonstrate that only densely connected networks can drive brain-wide seizure dynamics away from criticality. Importantly, such dense networks also disrupt the optimal computational capacities of critical networks, leading to chaotic dynamics, impaired network response properties and sticky states, thus helping to explain functional impairments during seizures. This study bridges the gap between microscale neuronal activity and emergent macroscale dynamics and cognitive dysfunction during seizures. SIGNIFICANCE STATEMENTEpileptic seizures are debilitating and impair normal brain function. It is unclear how the coordinated behavior of neurons collectively impairs brain function during seizures. To investigate this we perform fluorescence microscopy in larval zebrafish, which allows for the recording of whole-brain activity at single-neuron resolution. Using techniques from physics, we show that neuronal activity during seizures drives the brain away from criticality, a regime that enables both high and low activity states, into an inflexible regime that drives high activity states. Importantly, this change is caused by more connections in the network, which we show disrupts the ability of the brain to respond appropriately to its environment. Therefore, we identify key neuronal network mechanisms driving seizures and concurrent cognitive dysfunction. 

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2. Creation of Neuronal Ensembles and Cell-Specific Homeostatic Plasticity through Chronic Sparse Optogenetic Stimulation

   https://doi.org/10.1523/JNEUROSCI.1104-22.2022  

   Liu, Benjamin; Seay, Michael J.; Buonomano, Dean V. (November 2022, The Journal of Neuroscience)

   Cortical computations emerge from the dynamics of neurons embedded in complex cortical circuits. Within these circuits, neuronal ensembles, which represent subnetworks with shared functional connectivity, emerge in an experience-dependent manner. Here we induced ensembles inex vivocortical circuits from mice of either sex by differentially activating subpopulations through chronic optogenetic stimulation. We observed a decrease in voltage correlation, and importantly a synaptic decoupling between the stimulated and nonstimulated populations. We also observed a decrease in firing rate during Up-states in the stimulated population. These ensemble-specific changes were accompanied by decreases in intrinsic excitability in the stimulated population, and a decrease in connectivity between stimulated and nonstimulated pyramidal neurons. By incorporating the empirically observed changes in intrinsic excitability and connectivity into a spiking neural network model, we were able to demonstrate that changes in both intrinsic excitability and connectivity accounted for the decreased firing rate, but only changes in connectivity accounted for the observed decorrelation. Our findings help ascertain the mechanisms underlying the ability of chronic patterned stimulation to create ensembles within cortical circuits and, importantly, show that while Up-states are a global network-wide phenomenon, functionally distinct ensembles can preserve their identity during Up-states through differential firing rates and correlations. SIGNIFICANCE STATEMENTThe connectivity and activity patterns of local cortical circuits are shaped by experience. This experience-dependent reorganization of cortical circuits is driven by complex interactions between different local learning rules, external input, and reciprocal feedback between many distinct brain areas. Here we used anex vivoapproach to demonstrate how simple forms of chronic external stimulation can shape local cortical circuits in terms of their correlated activity and functional connectivity. The absence of feedback between different brain areas and full control of external input allowed for a tractable system to study the underlying mechanisms and development of a computational model. Results show that differential stimulation of subpopulations of neurons significantly reshapes cortical circuits and forms subnetworks referred to as neuronal ensembles. 

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3. Broadcasting in Noisy Radio Networks

   https://doi.org/10.1145/3087801.3087808  

   Censor-Hillel, Keren; Haeupler, Bernhard; Hershkowitz, D. Ellis; Zuzic, Goran (October 2017, ACM SIGACT-SIGOPS Symposium on Principles of Distributed Computing)

   The widely-studied radio network model [Chlamtac and Kutten, 1985] is a graph-based description that captures the inherent impact of collisions in wireless communication. In this model, the strong assumption is made that node v receives a message from a neighbor if and only if exactly one of its neighbors broadcasts. We relax this assumption by introducing a new noisy radio network model in which random faults occur at senders or receivers. Specifically, for a constant noise parameter p ∈ [0,1), either every sender has probability p of transmitting noise or every receiver of a single transmission in its neighborhood has probability p of receiving noise. We first study single-message broadcast algorithms in noisy radio networks and show that the Decay algorithm [Bar-Yehuda et al., 1992] remains robust in the noisy model while the diameter-linear algorithm of Gasieniec et al., 2007 does not. We give a modified version of the algorithm of Gasieniec et al., 2007 that is robust to sender and receiver faults, and extend both this modified algorithm and the Decay algorithm to robust multi-message broadcast algorithms, broadcasting Ω(1/log n log log n) and Ω(1/log n) messages per round, respectively. We next investigate the extent to which (network) coding improves throughput in noisy radio networks. In particular, we study the coding cap -- the ratio of the throughput of coding to that of routing -- in noisy radio networks. We address the previously perplexing result of Alon et al. 2014 that worst case coding throughput is no better than worst case routing throughput up to constants: we show that the worst case throughput performance of coding is, in fact, superior to that of routing -- by a Θ(log(n)) gap -- provided receiver faults are introduced. However, we show that sender faults have little effect on throughput. In particular, we show that any coding or routing scheme for the noiseless setting can be transformed to be robust to sender faults with only a constant throughput overhead. These transformations imply that the results of Alon et al., 2014 carry over to noisy radio networks with sender faults as well. As a result, if sender faults are introduced then there exist topologies for which there is a Θ(log log n) gap, but the worst case throughput across all topologies is Θ(1/log n) for both coding and routing. 

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4. Deep inference of latent dynamics with spatio-temporal super resolution using selective backpropagation through time

   Zhu, F; Sedler, AR; Grier, HA; Ahad, N; Davenport, MA; Kaufman, MT; Giovannucci, A; Pandarinath, C (January 2021, Advances in Neural Information Processing Systems (NeurIPS))

   Modern neural interfaces allow access to the activity of up to a million neurons within brain circuits. However, bandwidth limits often create a trade-off between greater spatial sampling (more channels or pixels) and the temporal frequency of sampling. Here we demonstrate that it is possible to obtain spatio-temporal super-resolution in neuronal time series by exploiting relationships among neurons, embedded in latent low-dimensional population dynamics. Our novel neural network training strategy, selective backpropagation through time (SBTT), enables learning of deep generative models of latent dynamics from data in which the set of observed variables changes at each time step. The resulting models are able to infer activity for missing samples by combining observations with learned latent dynamics. We test SBTT applied to sequential autoencoders and demonstrate more efficient and higher-fidelity characterization of neural population dynamics in electrophysiological and calcium imaging data. In electrophysiology, SBTT enables accurate inference of neuronal population dynamics with lower interface bandwidths, providing an avenue to significant power savings for implanted neuroelectronic interfaces. In applications to two-photon calcium imaging, SBTT accurately uncovers high-frequency temporal structure underlying neural population activity, substantially outperforming the current state-of-the-art. Finally, we demonstrate that performance could be further improved by using limited, high-bandwidth sampling to pretrain dynamics models, and then using SBTT to adapt these models for sparsely-sampled data. 

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5. Communicating with Anecdotes (Extended Abstract); Leibniz International Proceedings in Informatics (LIPIcs):15th Innovations in Theoretical Computer Science Conference (ITCS 2024)

   https://doi.org/10.4230/LIPIcs.ITCS.2024.57  

   Haghtalab, Nika; Immorlica, Nicole; Lucier, Brendan; Mobius, Markus; Mohan, Divyarthi (January 2024, Schloss Dagstuhl – Leibniz-Zentrum für Informatik)

   Guruswami, Venkatesan (Ed.)

   We study a communication game between a sender and receiver. The sender chooses one of her signals about the state of the world (i.e., an anecdote) and communicates it to the receiver who takes an action affecting both players. The sender and receiver both care about the state of the world but are also influenced by personal preferences, so their ideal actions can differ. We characterize perfect Bayesian equilibria. The sender faces a temptation to persuade: she wants to select a biased anecdote to influence the receiver’s action. Anecdotes are still informative to the receiver (who will debias at equilibrium) but the attempt to persuade comes at the cost of precision. This gives rise to informational homophily where the receiver prefers to listen to like-minded senders because they provide higher-precision signals. Communication becomes polarized when the sender is an expert with access to many signals, with the sender choosing extreme outlier anecdotes at equilibrium (unless preferences are perfectly aligned). This polarization dissipates all the gains from communication with an increasingly well-informed sender when the anecdote distribution is heavy-tailed. Experts therefore face a curse of informedness: receivers will prefer to listen to less-informed senders who cannot pick biased signals as easily. 

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