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Abstract We report a feasible method to control self‐recognition during the self‐assembly of a hydrophilic macroion, phosphate‐functionalized γ‐cyclodextrin (γ‐CD‐P), though host‐guest interactions. We confirmed that γ‐CD‐P can form a host‐guest complex with a super‐chaotropic anion, namely the B12F122−borate cluster, by using NMR spectroscopy and isothermal titration calorimetry. The loaded γ‐CD‐P, which has a higher charge density, can be distinguished from the uncomplexed γ‐CD‐P, leading to self‐sorting behavior during the self‐assembly process, confirmed by the formation of two types of individual supramolecular structures (Rhof ca. 57 nm and 18 nm, determined by light scattering) instead of hybrid structures in mixed dilute solution. This self‐recognition behavior is accounted for by the difference in intermolecular electrostatic interactions arising from the loading.
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This content will become publicly available on May 6, 2026
Expanding the toolbox for supramolecular chemistry: probing host–guest interactions and binding with in situ FTIR spectroscopy
In situFTIR spectroscopy can measureKavalues across different classes of host–guest complexes involving hydrogen and halogen bonding. This approach requires minimal sample preparation and can track host or guest vibrational changes.
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- Award ID(s):
- 2107602
- PAR ID:
- 10599046
- Publisher / Repository:
- Chemical Science
- Date Published:
- Journal Name:
- Chemical Science
- ISSN:
- 2041-6520
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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