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1. Building Flexible, Scalable, and Machine Learning-Ready Multimodal Oncology Datasets

   https://doi.org/10.3390/s24051634  

   Tripathi, Aakash; Waqas, Asim; Venkatesan, Kavya; Yilmaz, Yasin; Rasool, Ghulam (March 2024, Sensors)

   The advancements in data acquisition, storage, and processing techniques have resulted in the rapid growth of heterogeneous medical data. Integrating radiological scans, histopathology images, and molecular information with clinical data is essential for developing a holistic understanding of the disease and optimizing treatment. The need for integrating data from multiple sources is further pronounced in complex diseases such as cancer for enabling precision medicine and personalized treatments. This work proposes Multimodal Integration of Oncology Data System (MINDS)—a flexible, scalable, and cost-effective metadata framework for efficiently fusing disparate data from public sources such as the Cancer Research Data Commons (CRDC) into an interconnected, patient-centric framework. MINDS consolidates over 41,000 cases from across repositories while achieving a high compression ratio relative to the 3.78 PB source data size. It offers sub-5-s query response times for interactive exploration. MINDS offers an interface for exploring relationships across data types and building cohorts for developing large-scale multimodal machine learning models. By harmonizing multimodal data, MINDS aims to potentially empower researchers with greater analytical ability to uncover diagnostic and prognostic insights and enable evidence-based personalized care. MINDS tracks granular end-to-end data provenance, ensuring reproducibility and transparency. The cloud-native architecture of MINDS can handle exponential data growth in a secure, cost-optimized manner while ensuring substantial storage optimization, replication avoidance, and dynamic access capabilities. Auto-scaling, access controls, and other mechanisms guarantee pipelines’ scalability and security. MINDS overcomes the limitations of existing biomedical data silos via an interoperable metadata-driven approach that represents a pivotal step toward the future of oncology data integration. 

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2. A Heterogeneous Multimodal Graph Learning Framework for Recognizing User Emotions in Social Networks

   Bhattacharyya, Sree; Yang, Shuhua; Wang, James Z (September 2024, Proceedings of the International Conference on Affective Computing and Intelligent Interaction)

   The rapid expansion of social media platforms has provided unprecedented access to massive amounts of multimodal user-generated content. Comprehending user emotions can provide valuable insights for improving communication and understanding of human behaviors. Despite significant advancements in Affective Computing, the diverse factors influencing user emotions in social networks remain relatively understudied. Moreover, there is a notable lack of deep learning-based methods for predicting user emotions in social networks, which could be addressed by leveraging the extensive multimodal data available. This work presents a novel formulation of personalized emotion prediction in social networks based on heterogeneous graph learning. Building upon this formulation, we design HMG-Emo, a Heterogeneous Multimodal Graph Learning Framework that utilizes deep learning-based features for user emotion recognition. Additionally, we include a dynamic context fusion module in HMG-Emo that is capable of adaptively integrating the different modalities in social media data. Through extensive experiments, we demonstrate the effectiveness of HMG-Emo and verify the superiority of adopting a graph neural network-based approach, which outperforms existing baselines that use rich hand-crafted features. To the best of our knowledge, HMG-Emo is the first multimodal and deep-learning-based approach to predict personalized emotions within online social networks. Our work highlights the significance of exploiting advanced deep learning techniques for less-explored problems in Affective Computing. 

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3. Regulating Modality Utilization within Multimodal Fusion Networks

   https://doi.org/10.3390/s24186054  

   Singh, Saurav; Saber, Eli; Markopoulos, Panagiotis; Heard, Jamison (September 2024, Sensors)

   Multimodal fusion networks play a pivotal role in leveraging diverse sources of information for enhanced machine learning applications in aerial imagery. However, current approaches often suffer from a bias towards certain modalities, diminishing the potential benefits of multimodal data. This paper addresses this issue by proposing a novel modality utilization-based training method for multimodal fusion networks. The method aims to guide the network’s utilization on its input modalities, ensuring a balanced integration of complementary information streams, effectively mitigating the overutilization of dominant modalities. The method is validated on multimodal aerial imagery classification and image segmentation tasks, effectively maintaining modality utilization within ±10% of the user-defined target utilization and demonstrating the versatility and efficacy of the proposed method across various applications. Furthermore, the study explores the robustness of the fusion networks against noise in input modalities, a crucial aspect in real-world scenarios. The method showcases better noise robustness by maintaining performance amidst environmental changes affecting different aerial imagery sensing modalities. The network trained with 75.0% EO utilization achieves significantly better accuracy (81.4%) in noisy conditions (noise variance = 0.12) compared to traditional training methods with 99.59% EO utilization (73.7%). Additionally, it maintains an average accuracy of 85.0% across different noise levels, outperforming the traditional method’s average accuracy of 81.9%. Overall, the proposed approach presents a significant step towards harnessing the full potential of multimodal data fusion in diverse machine learning applications such as robotics, healthcare, satellite imagery, and defense applications. 

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4. I2MoE: Interpretable Multimodal Interaction-aware Mixture-of-Experts

   Xin, J; Yun, S; Peng, J; Choi, I; Ballard, J L; Chen, T; Long, Q (May 2025, https://doi.org/10.48550/arXiv.2505.19190)

   Modality fusion is a cornerstone of multimodal learning, enabling information integration from diverse data sources. However, vanilla fusion methods are limited by (1) inability to account for heterogeneous interactions between modalities and (2) lack of interpretability in uncovering the multimodal interactions inherent in the data. To this end, we propose I2MoE (Interpretable Multimodal Interaction-aware Mixture of Experts), an end-to-end MoE framework designed to enhance modality fusion by explicitly modeling diverse multimodal interactions, as well as providing interpretation on a local and global level. First, I2MoE utilizes different interaction experts with weakly supervised interaction losses to learn multimodal interactions in a data-driven way. Second, I2MoE deploys a reweighting model that assigns importance scores for the output of each interaction expert, which offers sample-level and dataset-level interpretation. Extensive evaluation of medical and general multimodal datasets shows that I2MoE is flexible enough to be combined with different fusion techniques, consistently improves task performance, and provides interpretation across various real-world scenarios. 

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5. Husformer: A Multimodal Transformer for Multimodal Human State Recognition

   https://doi.org/10.1109/TCDS.2024.3357618  

   Wang, Ruiqi; Jo, Wonse; Zhao, Dezhong; Wang, Weizheng; Gupte, Arjun; Yang, Baijian; Chen, Guohua; Min, Byung-Cheol (January 2024, IEEE Transactions on Cognitive and Developmental Systems)

   Human state recognition is a critical topic with pervasive and important applications in human–machine systems. Multimodal fusion, which entails integrating metrics from various data sources, has proven to be a potent method for boosting recognition performance. Although recent multimodal-based models have shown promising results, they often fall short in fully leveraging sophisticated fusion strategies essential for modeling adequate cross-modal dependencies in the fusion representation. Instead, they rely on costly and inconsistent feature crafting and alignment. To address this limitation, we propose an end-to-end multimodal transformer framework for multimodal human state recognition called Husformer. Specifically, we propose using cross-modal transformers, which inspire one modality to reinforce itself through directly attending to latent relevance revealed in other modalities, to fuse different modalities while ensuring sufficient awareness of the cross-modal interactions introduced. Subsequently, we utilize a self-attention transformer to further prioritize contextual information in the fusion representation. Extensive experiments on two human emotion corpora (DEAP and WESAD) and two cognitive load datasets [multimodal dataset for objective cognitive workload assessment on simultaneous tasks (MOCAS) and CogLoad] demonstrate that in the recognition of the human state, our Husformer outperforms both state-of-the-art multimodal baselines and the use of a single modality by a large margin, especially when dealing with raw multimodal features. We also conducted an ablation study to show the benefits of each component in Husformer. Experimental details and source code are available at https://github.com/SMARTlab-Purdue/Husformer. 

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