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Title: Sirtuins in Epigenetic Silencing and Control of Gene Expression in Model and Pathogenic Fungi
Fungi, including yeasts, molds, and mushrooms, proliferate on decaying matter and then adopt quiescent forms once nutrients are depleted. This review explores how fungi use sirtuin deacetylases to sense and respond appropriately to changing nutrients. Because sirtuins are NAD+-dependent deacetylases, their activity is sensitive to intracellular NAD+availability. This allows them to transmit information about a cell's metabolic state on to the biological processes they influence. Fungal sirtuins are primarily known to deacetylate histones, repressing transcription and modulating genome stability. Their target genes include those involved in NAD+homeostasis, metabolism, sporulation, secondary metabolite production, and virulence traits of pathogenic fungi. By targeting different genes over evolutionary time, sirtuins serve as rewiring points that allow organisms to evolve novel responses to low NAD+stress by bringing relevant biological processes under the control of sirtuins.  more » « less
Award ID(s):
1952281
PAR ID:
10634193
Author(s) / Creator(s):
;
Publisher / Repository:
Annual Reviews
Date Published:
Journal Name:
Annual Review of Microbiology
Volume:
76
Issue:
1
ISSN:
0066-4227
Page Range / eLocation ID:
157 to 178
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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