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Title: Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase
Long noncoding RNAs (lncRNAs) are relatively novel RNAs with increasingly prominent roles in regulating genetic expression, mainly in the nucleus but more recently in regions such as the mitochondrion. This study explores how lncRNAs interact with polynucleotide phosphorylase (PNPase), a protein that regulates RNA import into the mitochondrion. Machine learning identified several RNA structural features that improved lncRNA binding to PNPase, which may be useful in targeting RNA therapeutics to the mitochondrion.  more » « less
Award ID(s):
2125872
PAR ID:
10634938
Author(s) / Creator(s):
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Publisher / Repository:
American Physiological Society
Date Published:
Journal Name:
American Journal of Physiology-Cell Physiology
Volume:
327
Issue:
2
ISSN:
0363-6143
Page Range / eLocation ID:
C221 to C236
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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