Abstract ObjectivesWe estimate adult age frequencies from Unar 1 and Unar 2, two late Umm an‐Nar (2400–2100 BCE) tombs in the modern‐day Emirate of Ras al‐Khaimah, United Arab Emirates. These collective tombs each contained hundreds of skeletons in commingled, fragmented, and variably cremated states. Previous studies placed the vast majority of this mortuary community in a generalized “adult” category, as have most analyses of similar tombs from this period. We sought to test how adult age estimation methods compare in identifying young, middle, and old‐age individuals in commingled assemblages. Materials and MethodsWe employed Transition Analysis 3 (TA3) and traditional age estimation methods to generate adult age frequencies for each tomb. We compared these frequencies between tomb contexts as well as by method. ResultsUnar 1 and Unar 2 had similar adult age frequencies within each method, but TA3 age frequencies included significantly more middle and older adult individuals than those generated by traditional methods. DiscussionThese results support findings of earlier iterations of transition analysis in regard to sensitivity in old adult age estimation, compared with traditional methods. Our findings indicate a potential use of TA3 in reconstructing age frequencies and mortality profiles in commingled skeletal assemblages. Increasing our understanding of everyday life in the distant past necessitates better understandings of adult age, and here, we illustrate how age estimation method choice significantly changes bioarchaeological interpretations of aging in Bronze Age Arabia. Research HighlightsAdult age estimation using TA3 revealed significantly more middle and older adults than traditional methods in two commingled tombs.Similar mean maximum likelihood point estimates by side and across skeletal elements were found between tombs.
more »
« less
This content will become publicly available on March 31, 2026
Lepromatous leprosy in Bronze Age Oman: micro-CT provides tools for paleopathology in fragmentary and commingled assemblages
Paleoradiology uses CT scanning, digital radiography, and 3D imaging to non-invasively characterize the lives and the experience of health and disease for past people. This paper presents an analysis of micro-CT scans of leprosy in three archaeological maxillae from Dahwa, Oman (2500-2000 BCE) to characterize the natural history of disease progression on an ultra-structural level and address environmental and social factors that shaped the experience of health in Arabia during the Bronze Age. The human skeletal remains from Bronze Age Oman present a challenge for paleopathological analysis because they are fragmentary and commingled. We demonstrate microstructural characteristics of lesions in the ventral maxilla and palate that are strongly consistent with a diagnosis of lepromatous leprosy (e.g., atrophy of the anterior nasal spine, resorption of the medial alveolar process, deterioration of the piriform aperture margin, and atrophy of the nasal septum) and the utility of micro-CT for non-invasively characterizing pathology in isolated maxilla from fragmentary, commingled archaeological contexts. The presence of disfigurement, probably resulting from leprosy, in this community provides new evidence about the early migrations of pathogens responsible for leprosy, which despite being an ancient disease is still relatively poorly understood.
more »
« less
- Award ID(s):
- 2117299
- PAR ID:
- 10652565
- Publisher / Repository:
- Frontiers in Medicine
- Date Published:
- Journal Name:
- Frontiers in Medicine
- Volume:
- 12
- ISSN:
- 2296-858X
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Abstract Nasal turbinals, delicate and complex bones of the nasal cavity that support respiratory or olfactory mucosa (OM), are now easily studied using high resolution micro‐computed tomography (μ‐CT). Standard μ‐CT currently lacks the capacity to identify OM or other mucosa types without additional radio‐opaque staining techniques. However, even unstained mucosa is more radio‐opaque than air, and thus mucosal thickness can be discerned. Here, we assess mucosal thickness of the nasal fossa using the cranium of a cadaveric adult dog that was μ‐CT scanned with an isotropic resolution of 30 μm, and subsequently histologically sectioned and stained. After co‐alignment of μ‐CT slice planes to that of histology, mucosal thickness was estimated at four locations. Results based on either μ‐CT or histology indicate olfactory mucosa is thicker on average compared with non‐olfactory mucosa (non‐OM). In addition, olfactory mucosa has a lesser degree of variability than the non‐OM. Variability in the latter appears to relate mostly to the varying degree of vascularity of the lamina propria. Because of this, in structures with both specialized vascular respiratory mucosa and OM, such as the first ethmoturbinal (ET I), the range of thickness of OM and non‐OM may overlap. Future work should assess the utility of diffusible iodine‐based contrast enhanced CT techniques, which can differentiate epithelium from the lamina propria, to enhance our ability to differentiate mucosa types on more rostral ethmoturbinals. This is especially critical for structures such as ET I, which have mixed functional roles in many mammals.more » « less
-
ABSTRACT Politiko- Troullia has generated the largest radiocarbon ( 14 C) dataset from a Prehistoric Bronze Age settlement on Cyprus. We present Bayesian modeling of 25 calibrated AMS ages, which contributes to an emerging multi-site 14 C chronology for Cyprus covering most of the Prehistoric Bronze Age. Our analysis places the six stratified phases of occupation at Troullia between about 2050 and 1850 cal BCE, in contrast to a longer estimated occupation inferred from pottery analysis. We provide a rare 14 C determination for the transition from Prehistoric Bronze Age 1 to 2 just after 2000 cal BCE, associated with a major architectural dislocation at Politiko- Troullia in response to local landscape erosion, possibly due to increased regional precipitation. We present a regional 14 C model for Prehistoric Bronze Age Cyprus combining the chronology for Politiko- Troullia with modeled 14 C ages from Sotira Kaminoudhia and Marki Alonia , which is bolstered by individual ages from five other settlements on Cyprus. Through the Prehistoric Bronze Age, agrarian villages on Cyprus developed the foundations for the emergence of urbanized settlement and society during the ensuing Protohistoric Bronze Age. Politiko- Troullia , in conjunction with other key settlements on Cyprus, provides a significant independent contribution to increasingly robust Bronze Age 14 C chronologies in the Eastern Mediterranean.more » « less
-
The health benefits of switching from tobacco to electronic cigarettes (ECs) are neither confirmed nor well characterized. To address this problem, we used RNA-seq analysis to compare the nasal epithelium transcriptome from the following groups (n = 3 for each group): (1) former smokers who completely switched to second generation ECs for at least 6 months, (2) current tobacco cigarette smokers (CS), and (3) non-smokers (NS). Group three included one former cigarette smoker. The nasal epithelial biopsies from the EC users vs. NS had a higher number of differentially expressed genes (DEGs) than biopsies from the CS vs. NS and CS vs. EC sets (1817 DEGs total for the EC vs. NS, 407 DEGs for the CS vs. NS, and 116 DEGs for the CS vs. EC comparison). In the EC vs. NS comparison, enriched gene ontology terms for the downregulated DEGs included cilium assembly and organization, whereas gene ontologies for upregulated DEGs included immune response, keratinization, and NADPH oxidase. Similarly, ontologies for cilium movement were enriched in the downregulated DEGs for the CS vs. NS group. Reactome pathway analysis gave similar results and also identified keratinization and cornified envelope in the upregulated DEGs in the EC vs. NS comparison. In the CS vs. NS comparison, the enriched Reactome pathways for upregulated DEGs included biological oxidations and several metabolic processes. Regulator effects identified for the EC vs. NS comparison were inflammatory response, cell movement of phagocytes and degranulation of phagocytes. Disease Ontology Sematic Enrichment analysis identified lung disease, mouth disease, periodontal disease and pulmonary fibrosis in the EC vs. NS comparison. Squamous metaplasia associated markers, keratin 10, keratin 13 and involucrin, were increased in the EC vs. NS comparison. Our transcriptomic analysis showed that gene expression profiles associated with EC use are not equivalent to those from non-smokers. EC use may interfere with airway epithelium recovery by promoting increased oxidative stress, inhibition of ciliogenesis, and maintaining an inflammatory response. These transcriptomic alterations may contribute to the progression of diseases with chronic EC use.more » « less
-
ABSTRACT Analysis of 20 calibrated accelerator mass spectrometry radiocarbon (AMS14C) ages reveals a chronology for the habitation of a unique peripheral settlement at Zahrat adh-Dhra‘ 1 (ZAD 1), Jordan during the Middle Bronze Age of the Southern Levant. Bayesian modeling distinguishes three phases of occupation between the first settlement at ZAD 1, perhaps as early as about 2050 cal BCE, and its abandonment by 1700 cal BCE. ZAD 1 represents a marginal community, both environmentally and culturally, on the hyperarid Dead Sea Plain, and exemplifies the peripheral settlements that are envisioned as important elements of Bronze Age Levantine society. Most importantly for this study, it is the only peripheral site in the Southern Levant that provides a Bayesian model for its habitation during the growth of Middle Bronze Age urbanized society. The timing of ZAD 1’s constituent phases, early in Middle Bronze I, across the Middle Bronze I/II transition and in Middle Bronze II, correspond well with emerging chronologies for the Middle Bronze Age, thereby contributing to an ongoing reassessment of regional social and settlement dynamics.more » « less
An official website of the United States government
