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1. Design Space Identification of the Rotary Tablet Press

   https://doi.org/10.69997/sct.156711  

   Shahab, Mohammad; Bachawala, Sunidhi; Gonzalez, Marcial; Reklaitis, Gintaras; Nagy, Zoltan (July 2024, Systems & Control Transactions)

   The determination of the design space (DS) in a pharmaceutical process is a crucial aspect of the quality-by-design (QbD) initiative which promotes quality built into the desired product. This is achieved through a deep understanding of how the critical quality attributes (CQAs) and process parameters (CPPs) interact that have been demonstrated to provide quality assurance. For computational inexpensive models, the original process model can be directly deployed to identify the design space. One such crucial process is the Tablet Press (TP), which directly compresses the powder blend into individual units of the final product or adds dry or wet granulation to meet specific formulation needs. In this work, we identify the design space of input variables in a TP such that there is a (probabilistic) guarantee that the tablets meet the quality constraints under a set of operating conditions. A reduced-order model of TP is assigned for this purpose where the effects of lubricants and glidants are used to characterize the design space to achieve the desired tablet CQAs. The probabilistic design space, which takes into account interactions between crucial process parameters and important quality characteristics including model uncertainty, is also approximated because of the high cost associated with the comprehensive experiments. 

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2. Non-visual Perception of Lines on a Multimodal Touchscreen Tablet

   Tennison, J. L.; Gorlewicz, J. L. (January 2019, ACM transactions on applied perception)
3. Application of Model Based Predictive Control for a Rotary Tablet Press

   https://doi.org/10.1109/ICECCME62383.2024.10796835  

   Naşcu, Ioana; Nascu, Ioan; Nagy, Zoltan K (November 2024, IEEE)
4. Direct compression tablet formulation of trimetazidine through systematic screening of oxalate salts

   https://doi.org/10.1016/j.ijpharm.2025.125255  

   Ge, Yuebin; Yuan, Zhangyaoyu; Zhang, Mingzhen; Ming, Yuan; Huang, Xianju; Wang, Chenguang; Sun, Changquan Calvin (February 2025, International Journal of Pharmaceutics)
5. Strengthening the Community College Engineering Pipeline Using Tablet PCs and Online Instruction

   Enriquez, A. G. (June 2011, ASEE annual conference & exposition)

   The California Community College system has been very successful in providing affordable and accessible education to diverse student populations by allowing them to complete all of their lower-division course work and then transfer to a four-year institution to complete a bachelor’s degree. Recent developments, however, have threatened the viability of engineering programs in California community colleges, endangering this very important pipeline in the engineering educational system. The increasing divergence of the lower-division requirements among different four-year institutions and among the different fields of engineering, coupled with the recent State budget crisis has forced many community colleges to cancel low-enrollment classes and high-cost programs including those in engineering. In response to this situation, Cañada College, a federally designated Hispanic-serving institution in the San Francisco Bay Area, has developed an innovative program entitled Online and Networked Education for Students in Transfer Engineering Programs (ONE-STEP). Funded by the National Science Foundation Engineering Education and Centers through the Innovation in Engineering Education and Curriculum, and Infrastructure (IEECI) program, ONE-STEP aims to improve community college engineering education through the use of Tablet-PC and wireless network technologies. The program includes a Summer Engineering Teaching Institute that will assist community college engineering faculty in developing a Tablet-PC-enhanced interactive model of engineering instruction, and implementing online courses using CCC Confer—a videoconferencing platform that is available free of charge to all faculty and staff of the California Community College system. ONE-STEP will also develop partnerships with community colleges currently without an engineering program to design and implement a Joint Engineering Program that is delivered through CCC Confer. The program has the potential to significantly increase the viability of engineering programs by increasing teaching efficiency and effectiveness with minimal additional costs. 

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