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https://www.ncura.edu/Portals/0/Docs/RMR/2025/Vol28_n1_Eck_et_al.pdf 

Abstract Human mesenchymal stem cells (hMSCs) have gained traction in transplantation therapy due to their immunomodulatory, paracrine, immune‐evasive, and multipotent differentiation potential. The inherent heterogeneity of hMSCs poses a challenge for therapeutic treatments and necessitates the identification of robust biomarkers to ensure reproducibility in both in vivo and in vitro experiments. In this study, we utilized dielectrophoresis (DEP), a label‐free electrokinetic phenomenon, to investigate the heterogeneity of hMSCs derived from bone marrow (BM) and adipose tissue (AD). The electrical properties of BM‐hMSCs were compared to homogeneous mouse fibroblasts (NIH‐3T3), human fibroblasts (WS1), and human embryonic kidney cells (HEK‐293). The DEP profile of BM‐hMSCs differed most from HEK‐293 cells. We compared the DEP profiles of BM‐hMSCs and AD‐hMSCs and found that they have similar membrane capacitances, differing cytoplasm conductivity, and transient slopes. Inducing both populations to differentiate into adipocyte and osteoblast cells revealed that they behave differently in response to differentiation‐inducing cytokines. Histology and reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) analyses of the differentiation‐related genes revealed differences in heterogeneity between BM‐hMSCs and AD‐hMSCs. The differentiation profiles correlate well with the DEP profiles developed and indicate differences in the heterogeneity of BM‐hMSCs and AD‐hMSCs. Our results demonstrate that using DEP, membrane capacitance, cytoplasm conductivity, and transient slope can uniquely characterize the inherent heterogeneity of hMSCs to guide robust and reproducible stem cell transplantation therapies. 

Abstract This paper describes the cryogenic and purification systems of the ICARUS T600 detector in its present implementation at the Fermi National Laboratory, Illinois, U.S.A. The ICARUS T600 detector is made of four large Time Projection Chambers, installed in two separate containers of about 275 m³each. The detector uses liquid argon both as target and as active medium. For the correct operation of the detector, the liquid argon must be kept in very stable thermal conditions and the contamination of electronegative impurities must be consistently kept at the level of small fractions of parts per billion. The detector was previously operated in Italy, at the INFN Gran Sasso Underground Laboratory (LNGS), in a three-year run on the CERN to LNGS Long Baseline Neutrino Beam. For its operation on the Booster and NuMI neutrino beams at Fermilab, for the search of sterile neutrinos and measurements of neutrino-argon cross sections, the detector was moved from Gran Sasso to CERN for the upgrades required for operation at shallow depth with high intensity neutrino beams. The liquid argon containers, the thermal insulation and all the cryogenic equipment have been completely re-designed and rebuilt, following the schemes of the previous installation in Gran Sasso. The detector and all the equipment have been transported to Fermilab, where they have been installed, tested and recently put into operation. The work described in this paper has been conducted as a joint responsibility of CERN and Fermilab with the supervision provided by the ICARUS Collaboration. Design, installation, testing, commissioning and operation are the result of a common effort of CERN, Fermilab and INFN groups. 

Oxynitride perovskites of the type ABO 2 N have attracted considerable attention thanks to their potential ferroelectric behavior and tunable bandgap energy, making them ideal candidates for photocatalysis processes. Therefore, in order to shed light on the origin of their ferroelectric response, here we report a complete analysis of the structural and vibrational properties of SrNbO 2 N and SrTaO 2 N oxynitrides. By employing first-principles calculations, we analyzed the symmetry in-equivalent structures considering the experimentally reported parent I 4/ mcm space group (with a phase a 0 a 0 c − in Glazer's notation). Based on the I 4/ mcm reference within the 20-atoms unit-cell, we found and studied the ensemble of structures where different octahedral anionic orderings are allowed by symmetry. Thus, by exploring the vibrational landscape of the cis - and trans -type configuration structures and supported by the ionic eigendisplacements and the Born effective charges, we explained the mechanism responsible for the appearance of stable ferroelectric phases in both anionic orderings. The latter goes from covalent-driven in the trans -type ordering to the geometrically-driven in the cis -type configuration. Finally, we found in both cases that the biaxial xy epitaxial strain considerably enhances such ferroelectric response. 

A<sc>bstract</sc> A measurement of the angular structure of inclusive jets and those containing a prompt D⁰meson in proton-proton collisions at the LHC at a center-of-mass energy of 5.02 TeV is presented. The data corresponding to an integrated luminosity of 301 pb⁻¹were collected by the CMS experiment in 2017. Two jet grooming algorithms, late-k_Tand soft drop, are used to study the intrajet radiation pattern using iterative Cambridge-Aachen declustering. The splitting-angle distributions of jets with transverse momentum (p_T) of around 100 GeV, obtained with these two algorithms, show that there is a shift of the distribution for jets containing a prompt D⁰meson with respect to inclusive jets. The suppression of emissions at small angles observed in the late-k_Tgrooming approach is consistent with the dead-cone effect, whereas the similar suppression for splittings selected with the soft-drop algorithm appears to be induced by gluon splitting to charm quark-antiquark pairs at large angles. The measured distributions are corrected to the particle level and can be used to constrain model predictions for the substructure of high-p_Tcharm quark jets. 

We present a search for long-lived particles (LLPs), produced in kaon decays, that decay to two muons inside the ICARUS neutrino detector. This channel would be a signal of hidden sector models that can address outstanding issues in particle physics such as the strong CP problem and the microphysical origin of dark matter. The search is performed with data collected in the Neutrinos at the Main Injector (NuMI) beam at Fermilab corresponding to $2.41\times {10}^{20}$protons-on-target. No new physics signal is observed, and we set world leading limits on heavy QCD axions, as well as for the Higgs portal scalar among dedicated searches. Limits are also presented in a model-independent way applicable to any new physics model predicting the process $K\to \pi +S(\to \mu \mu )$, for a LLP $S$. This result is the first search for new physics performed with the ICARUS detector at Fermilab. It paves the way for the future program of LLP searches at ICARUS. Published by the American Physical Society2025