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Significant advances in bionic prosthetics have occurred in the past two decades. The field's rapid expansion has yielded many exciting technologies that can enhance the physical, functional, and cognitive integration of a prosthetic limb with a human. We review advances in the engineering of prosthetic devices and their interfaces with the human nervous system, as well as various surgical techniques for altering human neuromusculoskeletal systems for seamless human–prosthesis integration. We discuss significant advancements in research and clinical translation, focusing on upper limbprosthetics since they heavily rely on user intent for daily operation, although many discussed technologies have been extended to lower limb prostheses as well. In addition, our review emphasizes the roles of advanced prosthetics technologies in complex interactions with humans and the technology readiness levels (TRLs) of individual research advances. Finally, we discuss current gaps and controversies in the field and point out future research directions, guided by TRLs. 

Challenges associated with current prosthetic technologies limit the quality of life of lower-limb amputees. Passive prostheses lead amputees to walk slower, use more energy, fall more often, and modify their gait patterns to compensate for the prosthesis' lack of net-positive mechanical energy. Robotic prostheses can provide mechanical energy, but may also introduce challenges through controller design. Fortunately, talented researchers are studying how to best control robotic leg prostheses, but the time and resources required to develop prosthetic hardware has limited their potential impact. Even after research is completed, comparison of results is confounded by the use of different, researcher-specific hardware. To address these issues, we have developed the Open-source Leg (OSL): a scalable robotic knee/ankle prosthesis intended to foster investigations of control strategies. This paper introduces the design goals, transmission selection, hardware implementation, and initial control benchmarks for the OSL. The OSL provides a common hardware platform for comparison of control strategies, lowers the barrier to entry for prosthesis research, and enables testing within the lab, community, and at home.