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This work-in-progress study describes our grant-funded efforts in developing a computer science faculty learning community (FLC) across six California state institutions. With an emphasis on socially responsible computing (SRC), the faculty development effort that prepares faculty for SRC lesson implementation has integrated social scientists with computer science faculty in the rotating leadership team. It works collaboratively to facilitate dialog around experiences of implementing lessons that focus on social justice and ethical decision-making. Our data-driven FLC and course transformation effort was initiated by finding that retention rates in early computing courses at participating institutions were inequitable across demographic groups. The ultimate goal of the Broadening Participation in Computing Alliance for Socially Responsible Computing is to improve the retention rates of LatinX students by increasing their sense of belonging to the field of computer science[1] through deliberate and intentional connections of curriculum to real-world problems and social issues. For this paper, we focused on the faculty experiences of our most recent summer workshop and our reflection on the FLC implementation process. We present our faculty survey data from June 2024 and introduce reflective focus group findings [2], providing conjectures about the effectiveness of our approach. In the discussion, we build recommendations for collaborative professional development of faculty and discuss next steps. 

Socially Responsible Computing (SRC) education entails the infusion of Computer Science (CS) education with interwoven attention to ethical, social, and political issues to position students to reflect and take action individually and collaboratively to create a more just world. Our approach to SRC supports students to explore computing design/development in early CS courses with a communal goal orientation (in contrast to agentic/individualized), shown to improve achievement and retention for students with identities that are minoritized in CS. Grounded in our own experiences as co-developers and implementers of this pedagogical transformation and as co-facilitators of a Faculty Learning Community (FLC) across six minority-serving institutions in California, we share how we use an iterative design and implementation process modeled from social design experimentation as research and development method. Initial results are presented as a set of promising practices for incorporating SRC into introductory CS courses: 1) choose the domain mindfully; 2) design for synergy with technical material; 3) scaffold for inclusivity; 4) structure with a framework; 5) avoid othering SRC elements; and 6) reuse and build on existing resources. We share how these promising practices guide our efforts; how they can address challenges and concerns for new and continuing SRC implementers; and the ways in which we have and will continue to test and co-design this approach. 

Reactions of tris(ortho-carboranyl)borane with Lewis bases reveals only small bases bind. The tremendous bulk and Lewis acidity is leveraged in frustrated Lewis pair Si–H cleavage with a wider range of Lewis bases and greater efficacy than B(C₆F₅)₃. 

Abstract Cartilaginous fishes (chondrichthyans: chimeras and elasmobranchs -sharks, skates, and rays) hold a key phylogenetic position to explore the origin and diversifications of jawed vertebrates. Here, we report and integrate reference genomic, transcriptomic, and morphological data in the small-spotted catshark Scyliorhinus canicula to shed light on the evolution of sensory organs. We first characterize general aspects of the catshark genome, confirming the high conservation of genome organization across cartilaginous fishes, and investigate population genomic signatures. Taking advantage of a dense sampling of transcriptomic data, we also identify gene signatures for all major organs, including chondrichthyan specializations, and evaluate expression diversifications between paralogs within major gene families involved in sensory functions. Finally, we combine these data with 3D synchrotron imaging and in situ gene expression analyses to explore chondrichthyan-specific traits and more general evolutionary trends of sensory systems. This approach brings to light, among others, novel markers of the ampullae of Lorenzini electrosensory cells, a duplication hotspot for crystallin genes conserved in jawed vertebrates, and a new metazoan clade of the transient-receptor potential (TRP) family. These resources and results, obtained in an experimentally tractable chondrichthyan model, open new avenues to integrate multiomics analyses for the study of elasmobranchs and jawed vertebrates. 

Abstract Balancing kinetics, a crucial priority in catalysis, is frequently achieved by sacrificing activity of elementary steps to suppress side reactions and enhance catalyst stability. Dry reforming of methane (DRM), a process operated at high temperature, usually involves fast C-H activation but sluggish carbon removal, resulting in coke deposition and catalyst deactivation. Studies focused solely on catalyst innovation are insufficient in addressing coke formation efficiently. Herein, we develop coke-free catalysts that balance kinetics of elementary steps for overall thermodynamics optimization. Beginning from a highly active cobalt aluminum oxide (CoAl₂O₄) catalyst that is susceptible to severe coke formation, we substitute aluminum (Al) with gallium (Ga), reporting a CoAl_0.5Ga_1.5O₄-R catalyst that performs DRM stably over 1000 hours without observable coke deposition. We find that Ga enhances DRM stability by suppressing C-H activation to balance carbon removal. A series of coke-free DRM catalysts are developed herein by partially substituting Al from CoAl₂O₄with other metals. 

Infusion of broadly neutralizing antibodies (bNAbs) has shown promise as an alternative to anti-retroviral therapy against HIV. A key challenge is to suppress viral escape, which is more effectively achieved with a combination of bNAbs. Here, we propose a computational approach to predict the efficacy of a bNAb therapy based on the population genetics of HIV escape, which we parametrize using high-throughput HIV sequence data from bNAb-naive patients. By quantifying the mutational target size and the fitness cost of HIV-1 escape from bNAbs, we predict the distribution of rebound times in three clinical trials. We show that a cocktail of three bNAbs is necessary to effectively suppress viral escape, and predict the optimal composition of such bNAb cocktail. Our results offer a rational therapy design for HIV, and show how genetic data can be used to predict treatment outcomes and design new approaches to pathogenic control. 

Jumbo phages form “phage bouquets” during viral particle assembly and maturation, revealing novel phage assembly pathway. 

The Gram-positive bacterium Bacillus subtilis can divide via two modes. During vegetative growth, the division septum is formed at the midcell to produce two equal daughter cells. However, during sporulation, the division septum is formed closer to one pole to yield a smaller forespore and a larger mother cell. Using cryo-electron tomography, genetics and fluorescence microscopy, we found that the organization of the division machinery is different in the two septa. While FtsAZ filaments, the major orchestrators of bacterial cell division, are present uniformly around the leading edge of the invaginating vegetative septa, they are only present on the mother cell side of the invaginating sporulation septa. We provide evidence suggesting that the different distribution and number of FtsAZ filaments impact septal thickness, causing vegetative septa to be thicker than sporulation septa already during constriction. Finally, we show that a sporulation-specific protein, SpoIIE, regulates asymmetric divisome localization and septal thickness during sporulation.