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Spatial omics data demand computational analysis but many analysis tools have computational resource requirements that increase with the number of cells analyzed. This presents scalability challenges as researchers use spatial omics technologies to profile millions of cells.

To enhance the scalability of spatial omics data analysis, we developed a rasterization preprocessing framework called SEraster that aggregates cellular information into spatial pixels. We apply SEraster to both real and simulated spatial omics data prior to spatial variable gene expression analysis to demonstrate that such preprocessing can reduce computational resource requirements while maintaining high performance, including as compared to other down-sampling approaches. We further integrate SEraster with existing analysis tools to characterize cell-type spatial co-enrichment across length scales. Finally, we apply SEraster to enable analysis of a mouse pup spatial omics dataset with over a million cells to identify tissue-level and cell-type-specific spatially variable genes as well as spatially co-enriched cell types that recapitulate expected organ structures.

SEraster is implemented as an R package on GitHub (https://github.com/JEFworks-Lab/SEraster) with additional tutorials at https://JEF.works/SEraster.

 

The increased integration of artificial intelligence (AI) technologies in human workflows has resulted in a new paradigm of AI-assisted decision making,in which an AI model provides decision recommendations while humans make the final decisions. To best support humans in decision making, it is critical to obtain a quantitative understanding of how humans interact with and rely on AI. Previous studies often model humans' reliance on AI as an analytical process, i.e., reliance decisions are made based on cost-benefit analysis. However, theoretical models in psychology suggest that the reliance decisions can often be driven by emotions like humans' trust in AI models. In this paper, we propose a hidden Markov model to capture the affective process underlying the human-AI interaction in AI-assisted decision making, by characterizing how decision makers adjust their trust in AI over time and make reliance decisions based on their trust. Evaluations on real human behavior data collected from human-subject experiments show that the proposed model outperforms various baselines in accurately predicting humans' reliance behavior in AI-assisted decision making. Based on the proposed model, we further provide insights into how humans' trust and reliance dynamics in AI-assisted decision making is influenced by contextual factors like decision stakes and their interaction experiences.