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Time roots in applying language models for biomedical applications: models are trained on historical data and will be deployed for new or future data, which may vary from training data. While increasing biomedical tasks have employed state-of-the-art language models, there are very few studies have examined temporal effects on biomedical models when data usually shifts across development and deployment. This study fills the gap by statistically probing relations between language model performance and data shifts across three biomedical tasks. We deploy diverse metrics to evaluate model performance, distance methods to measure data drifts, and statistical methods to quantify temporal effects on biomedical language models. Our study shows that time matters for deploying biomedical language models, while the degree of performance degradation varies by biomedical tasks and statistical quantification approaches. We believe this study can establish a solid benchmark to evaluate and assess temporal effects on deploying biomedical language models. 

Automatic coding patient behaviors is essential to support decision making for psychotherapists during the motivational interviewing (MI), a collaborative communication intervention approach to address psychiatric issues, such as alcohol and drug addiction. While the behavior coding task has rapidly adapted language models to predict patient states during the MI sessions, lacking of domain-specific knowledge and overlooking patient-therapist interactions are major challenges in developing and deploying those models in real practice. To encounter those challenges, we introduce the Chain-of- Interaction (CoI) prompting method aiming to contextualize large language models (LLMs) for psychiatric decision support by the dyadic interactions. The CoI prompting approach systematically breaks down the coding task into three key reasoning steps, extract patient engagement, learn therapist question strategies, and integrates dyadic interactions between patients and therapists. This approach enables large language models to leverage the coding scheme, patient state, and domain knowledge for patient behavioral coding. Experiments on real-world datasets can prove the effectiveness and flexibility of our prompting method with multiple state-of-the-art LLMs over existing prompting baselines. We have conducted extensive ablation analysis and demonstrate the critical role of dyadic interactions in applying LLMs for psychotherapy behavior understanding.