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Creators/Authors contains: "Miller, Jacob"

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  1. When visualizing a high-dimensional dataset, dimension reduction techniques are commonly employed which provide a single 2 dimensional view of the data. We describe ENS-t-SNE: an algorithm for Embedding Neighborhoods Simultaneously that generalizes the t-Stochastic Neighborhood Embedding approach. By using different viewpoints in ENS-t-SNE’s 3D embedding, one can visualize different types of clusters within the same high-dimensional dataset. This enables the viewer to see and keep track of the different types of clusters, which is harder to do when providing multiple 2D embeddings, where corresponding points cannot be easily identified. We illustrate the utility of ENS-t-SNE with real-world applications and provide an extensive quantitative evaluation with datasets of different types and sizes. 
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  2. We present a method for balancing between the Local and Global Structures ( L G S ) in graph embedding, via a tunable parame- ter. Some embedding methods aim to capture global structures, while others attempt to preserve local neighborhoods. Few methods attempt to do both, and it is not always possible to capture well both local and global information in two dimensions, which is where most graph drawing live. The choice of using a local or a global embedding for visualization depends not only on the task but also on the structure of the underly-ing data, which may not be known in advance. For a given graph, L G S aims to find a good balance between the local and global structure to preserve. We evaluate the performance of L G S with synthetic and real- world datasets and our results indicate that it is competitive with the state-of-the-art methods, using established quality metrics such as stress and neighborhood preservation. We introduce a novel quality metric, cluster distance preservation, to assess intermediate structure capture. All source-code, datasets, experiments and analysis are available online. 
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  3. Force Field X (FFX) is an open-source software package for atomic resolution modeling of genetic variants and organic crystals that leverages advanced potential energy functions and experimental data. FFX currently consists of nine modular packages with novel algorithms that include global optimization via a many-body expansion, acid–base chemistry using polarizable constant-pH molecular dynamics, estimation of free energy differences, generalized Kirkwood implicit solvent models, and many more. Applications of FFX focus on the use and development of a crystal structure prediction pipeline, biomolecular structure refinement against experimental datasets, and estimation of the thermodynamic effects of genetic variants on both proteins and nucleic acids. The use of Parallel Java and OpenMM combines to offer shared memory, message passing, and graphics processing unit parallelization for high performance simulations. Overall, the FFX platform serves as a computational microscope to study systems ranging from organic crystals to solvated biomolecular systems. 
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    Free, publicly-accessible full text available July 7, 2025
  4. In circuit quantum electrodynamics, qubits are typically measured using dispersively coupled readout resonators. Coupling between each readout resonator and its electrical environment, however, reduces the qubit lifetime via the Purcell effect. Inserting a Purcell filter counters this effect while maintaining high readout fidelity but reduces measurement bandwidth and, thus, limits multiplexing readout capacity. In this Letter, we develop and implement a multi-stage bandpass Purcell filter that yields better qubit protection while simultaneously increasing measurement bandwidth and multiplexed capacity. We report on the experimental performance of our transmission-line-based implementation of this approach, a flexible design that can easily be integrated with current scaled-up, long coherence time superconducting quantum processors. 
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  5. Abstract The neuroanatomical changes that underpin cognitive development are of major interest in neuroscience. Of the many aspects of neuroanatomy to consider, tertiary sulci are particularly attractive as they emerge last in gestation, show a protracted development after birth, and are either human- or hominoid-specific. Thus, they are ideal targets for exploring morphological-cognitive relationships with cognitive skills that also show protracted development such as working memory (WM). Yet, the relationship between sulcal morphology and WM is unknown—either in development or more generally. To fill this gap, we adopted a data-driven approach with cross-validation to examine the relationship between sulcal depth in lateral prefrontal cortex (LPFC) and verbal WM in 60 children and adolescents between ages 6 and 18. These analyses identified 9 left, and no right, LPFC sulci (of which 7 were tertiary) whose depth predicted verbal WM performance above and beyond the effect of age. Most of these sulci are located within and around contours of previously proposed functional parcellations of LPFC. This sulcal depth model outperformed models with age or cortical thickness. Together, these findings build empirical support for a classic theory that tertiary sulci serve as landmarks in association cortices that contribute to late-maturing human cognitive abilities. 
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