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This work elucidates a route to mesoporous magnetic materials with co-continuous morphologies from block copolymer self-assembly. The co-continuous structure impacts the magnetic behavior compared to non-structured chemically-identical materials. 

Fluid flow around a random distribution of stationary spherical particles is a problem of substantial importance in the study of dispersed multiphase flows. In this paper we present a machine learning methodology using Generative Adversarial Network framework and Convolutional Neural Network architecture to recreate particle-resolved fluid flow around a random distribution of monodispersed particles. The model was applied to various Reynolds number and particle volume fraction combinations spanning over a range of [2.69, 172.96] and [0.11, 0.45] respectively. Test performance of the model for the studied cases is very promising. 

Abstract Oral delivery, while a highly desirable form of nanoparticle‐drug administration, is limited by challenges associated with overcoming several biological barriers. Here, the authors study how fluorescent and poly(ethylene glycol)‐coated (PEGylated) core‐shell silica nanoparticles sized 5 to 50 nm interact with major barriers including intestinal mucus, intestinal epithelium, and stomach acid. From imaging fluorescence correlation spectroscopy studies using quasi‐total internal reflection fluorescence microscopy, diffusion of nanoparticles through highly scattering mucus is progressively hindered above a critical hydrodynamic size around 20 nm. By studying Caco‐2 cell monolayers mimicking the intestinal epithelia, it is observed that ultrasmall nanoparticles below 10 nm diameter (Cornell prime dots, [C’ dots]) show permeabilities correlated with high absorption in humans from primarily enhanced passive passage through tight junctions. Particles above 20 nm diameter exclusively show active transport through cells. After establishing C’ dot stability in artificial gastric juice, in vivo oral gavage experiments in mice demonstrate successful passage through the body followed by renal clearance without protein corona formation. Results suggest C’ dots as viable candidates for oral administration to patients with a proven pathway towards clinical translation and may generate renewed interest in examining silica as a food additive and its effects on nutrition and health.