skip to main content

Search for: All records

Creators/Authors contains: "Wang, Wei"

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

  1. Abstract Branched-chain amino acid (BCAA) metabolism fulfills numerous physiological roles and can be harnessed to produce valuable chemicals. However, the lack of eukaryotic biosensors specific for BCAA-derived products has limited the ability to develop high-throughput screens for strain engineering and metabolic studies. Here, we harness the transcriptional regulator Leu3p from Saccharomyces cerevisiae to develop a genetically encoded biosensor for BCAA metabolism. In one configuration, we use the biosensor to monitor yeast production of isobutanol, an alcohol derived from valine degradation. Small modifications allow us to redeploy Leu3p in another biosensor configuration that monitors production of the leucine-derived alcohol, isopentanol. Thesemore »biosensor configurations are effective at isolating high-producing strains and identifying enzymes with enhanced activity from screens for branched-chain higher alcohol (BCHA) biosynthesis in mitochondria as well as cytosol. Furthermore, this biosensor has the potential to assist in metabolic studies involving BCAA pathways, and offers a blueprint to develop biosensors for other products derived from BCAA metabolism.« less
    Free, publicly-accessible full text available December 1, 2023
  2. Abstract Single-crystalline nickel-rich cathodes are a rising candidate with great potential for high-energy lithium-ion batteries due to their superior structural and chemical robustness in comparison with polycrystalline counterparts. Within the single-crystalline cathode materials, the lattice strain and defects have significant impacts on the intercalation chemistry and, therefore, play a key role in determining the macroscopic electrochemical performance. Guided by our predictive theoretical model, we have systematically evaluated the effectiveness of regaining lost capacity by modulating the lattice deformation via an energy-efficient thermal treatment at different chemical states. We demonstrate that the lattice structure recoverability is highly dependent on both themore »cathode composition and the state of charge, providing clues to relieving the fatigued cathode crystal for sustainable lithium-ion batteries.« less
    Free, publicly-accessible full text available December 1, 2023
  3. Free, publicly-accessible full text available August 14, 2023
  4. Free, publicly-accessible full text available August 1, 2023
  5. Free, publicly-accessible full text available July 1, 2023
  6. Free, publicly-accessible full text available June 19, 2023
  7. Free, publicly-accessible full text available April 10, 2023
  8. Free, publicly-accessible full text available March 1, 2023
  9. Within-person research has become increasingly popular in Psychology for its unique theoretical and methodological advantages for studying dynamic psychological processes. Despite the advancements, there remain serious challenges for many organizational researchers to fully appreciate and appropriately implement within-person research—more specifically, to correctly conceptualize and compute the within-person measurement reliability, as well as navigate key within-person research design factors (e.g., number of measurement occasions, T; number of participants, N; and scale length, I) to optimize within-person reliability. By conducting a comprehensive Monte Carlo simulation with 3240 data conditions, we offer a practical guideline table showing the expected within-person reliability as amore »function of key design factors. In addition, we provide three easy-to-use, free R Shiny web applications for within-person researchers to conveniently (a) compute expected within-person reliability based on their customized research design, (b) compute observed validity based on the expected reliability and hypothesized within-person validity, and (c) compute observed within-person (as well as between-person) reliability from collected within-person research datasets. We hope these much-needed evidence-based guidelines and practical tools will help enhance within-person research in organizational studies.« less
    Free, publicly-accessible full text available March 14, 2023
  10. Free, publicly-accessible full text available May 6, 2023