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  1. Free, publicly-accessible full text available October 23, 2024
  2. Abstract

    Two-dimensional (2D) materials have drawn immense interests in scientific and technological communities, owing to their extraordinary properties and their tunability by gating, proximity, strain and external fields. For electronic applications, an ideal 2D material would have high mobility, air stability, sizable band gap, and be compatible with large scale synthesis. Here we demonstrate air stable field effect transistors using atomically thin few-layer PdSe2sheets that are sandwiched between hexagonal BN (hBN), with large saturation current > 350 μA/μm, and high field effect mobilities of ~ 700 and 10,000 cm2/Vs at 300 K and 2 K, respectively. At low temperatures, magnetotransport studies reveal unique octets in quantum oscillations that persist at all densities, arising from 2-fold spin and 4-fold valley degeneracies, which can be broken by in-plane and out-of-plane magnetic fields toward quantum Hall spin and orbital ferromagnetism.

     
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  3. Charging processes are the key to promoting electric taxis and improving their operational efficiency due to frequent charging activities and long charging time. Nevertheless, optimizing charging resource allocation in real time is extremely challenging because of uneven charging demand/supply distributions, heuristic-based charging behaviors of drivers, and city-scale of the fleets. The existing solutions have utilized real-time contextual information for charging recommendation, but they do not consider the much-richer fleet information, leading to the suboptimal individual-based charging recommendation. In this paper, we design a data-driven fleet-oriented charging recommendation system for charging resource allocation called ForETaxi for electric taxis , which aims to minimize the overall charging overhead for the entire fleet, instead of individual vehicles. ForETaxi considers not only current charging requests but also possible charging requests of other nearby electric taxis in the near future by inferring their status in real time. More importantly, we implement ForETaxi with multiple types of sensor data from the Chinese Shenzhen city including GPS data, and taxi transaction data from more than 13,000 electric taxis, combined with road network data and charging station data. The data-driven evaluation results show that compared to the state-of-the-art individual-based recommendation methods, our fleet-oriented ForETaxi outperforms them by 16% in the total charging time reduction and 82% in the queuing time reduction. 
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    Free, publicly-accessible full text available August 31, 2024
  4. In genomic analysis, the major computation bottle- neck is the memory- and compute-intensive DNA short reads alignment due to memory-wall challenge. This work presents the first Resistive RAM (RRAM) based Compute-in-Memory (CIM) macro design for accelerating state-of-the-art BWT based genome sequencing alignment. Our design could support all the core instructions, i.e., XNOR based match, count, and addition, required by alignment algorithm. The proposed CIM macro implemented in integration of HfO2 RRAM and 65nm CMOS demonstrates the best energy efficiency to date with 2.07 TOPS/W and 2.12G suffixes/J at 1.0V. 
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    Free, publicly-accessible full text available September 1, 2024
  5. Channel decoders are key computing modules in wired/wireless communication systems. Recently neural network (NN)-based decoders have shown their promising error-correcting performance because of their end-to-end learning capability. However, compared with the traditional approaches, the emerging neural belief propagation (NBP) solution suffers higher storage and computational complexity, limiting its hardware performance. To address this challenge and develop a channel decoder that can achieve high decoding performance and hardware performance simultaneously, in this paper we take a first step towards exploring SRAM-based in-memory computing for efficient NBP channel decoding. We first analyze the unique sparsity pattern in the NBP processing, and then propose an efficient and fully Digital Sparse In-Memory Matrix vector Multiplier (DSPIMM) computing platform. Extensive experiments demonstrate that our proposed DSPIMM achieves significantly higher energy efficiency and throughput than the state-of-the-art counterparts. 
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    Free, publicly-accessible full text available July 9, 2024
  6. Free, publicly-accessible full text available June 1, 2024
  7. Due to the often limited communication bandwidth of edge devices, most existing federated learning (FL) methods randomly select only a subset of devices to participate in training at each communication round. Compared with engaging all the available clients, such a random-selection mechanism could lead to significant performance degradation on non-IID (independent and identically distributed) data. In this paper, we present our key observation that the essential reason resulting in such performance degradation is the class-imbalance of the grouped data from randomly selected clients. Based on this observation, we design an efficient heterogeneity-aware client sampling mechanism, namely, Federated Class-balanced Sampling (Fed-CBS), which can effectively reduce class-imbalance of the grouped dataset from the intentionally selected clients. We first propose a measure of class-imbalance which can be derived in a privacy-preserving way. Based on this measure, we design a computationefficient client sampling strategy such that the actively selected clients will generate a more classbalanced grouped dataset with theoretical guarantees. Experimental results show that Fed-CBS outperforms the status quo approaches in terms of test accuracy and the rate of convergence while achieving comparable or even better performance than the ideal setting where all the available clients participate in the FL training. 
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    Free, publicly-accessible full text available July 23, 2024
  8. Abstract

    We have examined the roles of yeast mRNA decapping-activators Pat1 and Dhh1 in repressing the translation and abundance of specific mRNAs in nutrient-replete cells using ribosome profiling, RNA-Seq, CAGE analysis of capped mRNAs, RNA Polymerase II ChIP-Seq, and TMT-mass spectrometry of mutants lacking one or both factors. Although the Environmental Stress Response (ESR) is activated in dhh1Δ and pat1Δ mutants, hundreds of non-ESR transcripts are elevated in a manner indicating cumulative repression by Pat1 and Dhh1 in wild-type cells. These mRNAs show both reduced decapping and diminished transcription in the mutants, indicating that impaired mRNA turnover drives transcript derepression in cells lacking Dhh1 or Pat1. mRNA degradation stimulated by Dhh1/Pat1 is not dictated by poor translation nor enrichment for suboptimal codons. Pat1 and Dhh1 also collaborate to reduce translation and protein production from many mRNAs. Transcripts showing concerted translational repression by Pat1/Dhh1 include mRNAs involved in cell adhesion or utilization of the poor nitrogen source allantoin. Pat1/Dhh1 also repress numerous transcripts involved in respiration, catabolism of non-preferred carbon or nitrogen sources, or autophagy; and we obtained evidence for elevated respiration and autophagy in the mutants. Thus, Pat1 and Dhh1 function as post-transcriptional repressors of multiple pathways normally activated only during nutrient limitation.

     
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    Free, publicly-accessible full text available July 13, 2024
  9. Abstract

    We communicate a feasibility study for high‐resolution structural characterization of biomacromolecules in aqueous solution from X‐ray scattering experiments measured over a range of scattering vectors (q) that is approximately two orders of magnitude wider than used previously for such systems. Scattering data with such an extendedq‐range enables the recovery of the underlying real‐space atomic pair distribution function, which facilitates structure determination. We demonstrate the potential of this method for biomacromolecules using several types of cyclodextrins (CD) as model systems. We successfully identified deviations of the tilting angles for the glycosidic units in CDs in aqueous solutions relative to their values in the crystalline forms of these molecules. Such level of structural detail is inaccessible from standard small angle scattering measurements. Our results call for further exploration of ultra‐wide‐angle X‐ray scattering measurements for biomacromolecules.

     
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    Free, publicly-accessible full text available June 2, 2024
  10. Free, publicly-accessible full text available March 1, 2024