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Abstract Cisplatin, the first platinum chemotherapy agent to obtain Food and Drug Administration (FDA) approval in 1978, is widely used for a number of cancers. However, the painful side effects stemming from systemic delivery are the inevitable limitation of cisplatin. A possible solution is regional chemotherapy using various drug delivery systems, which reduces the systemic toxicity and increases drug accumulation in the tumor. In this paper, a rice‐grain sized, ultrasonically powered, and implantable microdevice that can synthesize cisplatin in situ is presented. The microdevice produces 0.7 mg of cisplatin within 1 h under ultrasonic irradiation (400 mW cm⁻²). The effect of the microdevice‐synthesized cisplatin is evaluated using in vitro murine breast cancer cells and ex vivo liver tissue. The results suggest that cytotoxic activities of the microdevice‐mediated cisplatin delivery are significantly higher in both in vitro and ex vivo experiments. Overall, the proposed cisplatin synthesis microdevice represents a strong alternative treatment option for regional chemotherapy 

Biomedical systems of implanted miniaturized sensors and actuators interconnected into an intra-body area net-work could revolutionize treatment options for chronic diseases afflicting internal organs. Considering the well-understood limitations of radio frequency (RF) propagation in the human body, we have explored magnetic resonance (MR) coupling for both communications and energy transfer through the body. In this paper, we have discussed the design and implementation of a software-defined prototype using Universal Software Radio Peripheral (USRP) boards. We have reported experimental results on the achieved packet error rates at different positions through-the-body distances and packet sizes. We have observed experimentally that the MR signal propagates through the body substantially better than in the air, and can provide a practical means for energy transfer and communications in intra-body networks. It also works better than the better understood galvanic coupling. 

Effective management of emerging medical devices can lead to new insights in healthcare. Thus, a human body communication (HBC) is becoming increasingly important. In this paper, we present magnetic resonance (MR) coupling as a promising method for intra-body network (IBNet). The study reveals that MR coupling can effectively send or receive signals in biological tissue, with a maximum path loss of PL 33 dB (i.e. at 13.56 MHz), which is lower than other methods (e.g., galvanic, capacitive, or RF) for the same distance. The angular orientation of the transmitter and receiver coils at short and long distances also show a minor variation of the path loss (0.19 PL 0.62 dB), but more dependency on the distance (0.0547 dB/cm). Additionally, different postures during the MR coupling essentially do not affect path loss (PL 0.21 dB). In the multi-nodal transmission scenario, the MR coupling demonstrates that two nodes can simultaneously receive signals with -16.77 dBm loss at 60 cm and 100 cm distances, respectively. Such multi-node MR transmission can be utilized for communication, sensing, and powering wearable and implantable devices. 

Continuous monitoring of biochemical information is critical for health management. Hydrogel, a synthetic material that exhibits volumetric response to target stimuli, is an attractive material for such applications. However, wireless readout of the hydrogel's response over a longer distance, while maintaining the small sensor dimension has been challenging. In this work we present ferrogel-based wireless acousto-biochemical sensing system with small dimension (length: 7.5 mm, diameter: 2 mm) and long sensing distance (>10 cm). The sensor utilizes ferromagnetic hydrogel to convert pH to the change in resonance frequency; the wireless measurement is made through the RF signal emission under ultrasonic excitation. 

In this paper, we introduce an oral motion-powered Smart Tooth system that can monitor oral health. Lower pH is an indicator of bacterial accumulation in the oral cavity, which can cause tooth decay, periodontal or peri-implant diseases. Thus, in situ monitoring pH inside of the mouth is critical to prevent oral diseases. Using a piezoelectric dental crown, Smart Tooth system converts oral motions, such as chewing, to electrical power which can impinge a surface integrated LC transponder. The LC transponder also incorporates iron oxide nanoparticles-embedded pH-sensitive hydrogel that modulates the resonant frequency via shrinking or swelling. As a proof of concept, the fabricated prototype measures pH levels ranging from pH 4 to 12 and sends data wirelessly to the receiver placed up to 5 cm away (wireless transmission path loss at 3 cm was 50.79 dB). The results indicate that the Smart Tooth system can monitor oral health while replacing missing teeth. 

Wireless monitoring of the physio-biochemical information is becoming increasingly important for healthcare. In this work, we present a proof-of-concept hydrogel-based wireless biochemical sensing scheme utilizing ultrasound. The sensing system utilizes silica-nanoparticle embedded hydrogel deposited on a thin glass substrate, which presents two prominent interfaces for ultrasonic backscattering (tissue/glass and hydrogel/glass). To overcome the effect of the varying acoustic properties of the intervening biological tissues between the sensor and the external transducer, we implemented a differential mode of ultrasonic back-scattering. Here, we demonstrate a wireless pH measurement with a resolution of 0.2 pH level change and a wireless sensing range around 10 cm in a water tank. 

In this work, we present a proof-of-concept hydrogel-based sensor system capable of wireless biochemical sensing through measuring backscattered ultrasound. The system consists of silica-nanoparticle embedded hydrogel deposited on a thin glass substrate, presenting two interfaces for backscattering (tissue/hydrogel and hydrogel/glass), which allows for system output to be invariant under the change in acoustic properties (e.g. attenuation, reflection) of the intervening biological tissue. We characterize the effect of silica nanoparticles (acoustic contrast agents) loading on the hydrogel's swelling ratio and its ultrasonic backscattering properties. We demonstrate a wireless pH measurement using dual modes of interrogations, reflection ratio and time delay. The ultrasonic hydrogel pH sensor is demonstrated with a sensing resolution of 0.2 pH level change with a wireless sensing distance around 10 cm. 

This paper reports on a novel transducer for wireless biochemical sensing. The bilayer transducer consists of a fractal piezoelectric membrane and pH-sensitive chemo-mechanical hydrogel, which overcomes many shortcomings in the chemical and biochemical sensing. The fractal design on the piezoelectric membrane enhances frequency response and linearity by employing periodically repeated pore architecture. As a basis of the pore, a Hilbert space-filling curve with modifications is used. On the surface of the fractal piezoelectric membrane, the hydrogel is laminated. When the bilayer transducer is introduced to a pH environment (e.g., pH = 4, 8, and 12), the hydrogel swells (or shrinks) and induces the curling of the bilayer transducer (10.47°/pH). The curvature then exhibits various ultrasound responses when the bilayer transducer was excited. The measured voltage outputs using an ultrasonic receiver were 0.393, 0.341, 0.250 mV/cm 2 when curvature angles were 30°, 60°, and 120°, respectively. Overall pH sensitivity was 0.017 mV/cm 2 /pH. Ultimately, the biochemical sensing principle using a novel bilayer ultrasound transducer suggests a simple, low-cost, battery-less, and long-range wireless readout system as compared to traditional biochemical sensing.