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Abstract High-throughput and cost-efficient fabrication of intricate nanopatterns using top-down approaches remains a significant challenge. To overcome this limitation, advancements are required across various domains: patterning techniques, real-time and post-process metrology, data analysis, and, crucially, process control. We review recent progress in continuous, top-down nanomanufacturing, with a particular focus on data-driven process control strategies. We explore existing Machine Learning (ML)-based approaches for implementing key aspects of continuous process control, encompassing high-speed metrology balancing speed and resolution, modeling relationships between process parameters and yield, multimodal data fusion for comprehensive process monitoring, and control law development for real-time process adjustments. To assess the applicability of established control strategies in continuous settings, we compare roll-to-roll (R2R) manufacturing, a paradigmatic continuous multistage process, with the well-established batch-based semiconductor manufacturing. Finally, we outline promising future research directions for achieving high-quality, cost-effective, top-down nanomanufacturing and particularly R2R nanomanufacturing at scale.