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Abstract Chemotaxis phenomena govern the directed movement of microorganisms in response to chemical stimuli. In this paper, we investigate two Keller–Segel systems of reaction–advection–diffusion equations modeling chemotaxis on thin networks. The distinction between two systems is driven by the rate of diffusion of the chemo-attractant. The intermediate rate of diffusion is modeled by a coupled pair of parabolic equations, while the rapid rate is described by a parabolic equation coupled with an elliptic one. Assuming the polynomial rate of growth of the chemotaxis sensitivity coefficient, we prove local well-posedness of both systems on compact metric graphs, and, in particular, prove existence of unique classical solutions. This is achieved by constructing sufficiently regular mild solutions via analytic semigroup methods and combinatorial description of the heat kernel on metric graphs. The regularity of mild solutions is shown by applying abstract semigroup results to semi-linear parabolic equations on compact graphs. In addition, for logistic-type Keller–Segel systems we prove global well-posedness and, in some special cases, global uniform boundedness of solutions. 

Abstract This work offers a new prospective on asymptotic perturbation theory for varying self‐adjoint extensions of symmetric operators. Employing symplectic formulation of self‐adjointness, we use a version of resolvent difference identity for two arbitrary self‐adjoint extensions that facilitates asymptotic analysis of resolvent operators via first‐order expansion for the family of Lagrangian planes associated with perturbed operators. Specifically, we derive a Riccati‐type differential equation and the first‐order asymptotic expansion for resolvents of self‐adjoint extensions determined by smooth one‐parameter families of Lagrangian planes. This asymptotic perturbation theory yields a symplectic version of the abstract Kato selection theorem and Hadamard–Rellich‐type variational formula for slopes of multiple eigenvalue curves bifurcating from an eigenvalue of the unperturbed operator. The latter, in turn, gives a general infinitesimal version of the celebrated formula equating the spectral flow of a path of self‐adjoint extensions and the Maslov index of the corresponding path of Lagrangian planes. Applications are given to quantum graphs, periodic Kronig–Penney model, elliptic second‐order partial differential operators with Robin boundary conditions, and physically relevant heat equations with thermal conductivity. 

This paper concerns asymptotic stability, instability, and bifurcation of constant steady state solutions of the parabolic-parabolic and parabolic-elliptic chemotaxis models on metric graphs. We determine a threshold value $$\chi^*>0$$ of the chemotaxis sensitivity parameter that separates the regimes of local asymptotic stability and instability, and, in addition, determine the parameter intervals that facilitate global asymptotic convergence of solutions with positive initial data to constant steady states. Moreover, we provide a sequence of bifurcation points for the chemotaxis sensitivity parameter that yields non-constant steady state solutions. In particular, we show that the first bifurcation point coincides with threshold value $$\chi^*$$ for a generic compact metric graph. Finally, we supply numerical computation of bifurcation points for several graphs.