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Chemotaxis describes the movement of an organism, such as single or multi-cellular organisms and bacteria, in response to a chemical stimulus. Two widely used models to describe the phenomenon are the celebrated Keller–Segel equation and a chemotaxis kinetic equation. These two equations describe the organism’s movement at the macro- and mesoscopic level, respectively, and are asymptotically equivalent in the parabolic regime. The way in which the organism responds to a chemical stimulus is embedded in the diffusion/advection coefficients of the Keller–Segel equation or the turning kernel of the chemotaxis kinetic equation. Experiments are conducted to measure the time dynamics of the organisms’ population level movement when reacting to certain stimulation. From this, one infers the chemotaxis response, which constitutes an inverse problem. In this paper, we discuss the relation between both the macro- and mesoscopic inverse problems, each of which is associated with two different forward models. The discussion is presented in the Bayesian framework, where the posterior distribution of the turning kernel of the organism population is sought. We prove the asymptotic equivalence of the two posterior distributions.
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Well-posedness of Keller–Segel systems on compact metric graphs
Abstract Chemotaxis phenomena govern the directed movement of microorganisms in response to chemical stimuli. In this paper, we investigate two Keller–Segel systems of reaction–advection–diffusion equations modeling chemotaxis on thin networks. The distinction between two systems is driven by the rate of diffusion of the chemo-attractant. The intermediate rate of diffusion is modeled by a coupled pair of parabolic equations, while the rapid rate is described by a parabolic equation coupled with an elliptic one. Assuming the polynomial rate of growth of the chemotaxis sensitivity coefficient, we prove local well-posedness of both systems on compact metric graphs, and, in particular, prove existence of unique classical solutions. This is achieved by constructing sufficiently regular mild solutions via analytic semigroup methods and combinatorial description of the heat kernel on metric graphs. The regularity of mild solutions is shown by applying abstract semigroup results to semi-linear parabolic equations on compact graphs. In addition, for logistic-type Keller–Segel systems we prove global well-posedness and, in some special cases, global uniform boundedness of solutions.
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- Award ID(s):
- 2418900
- PAR ID:
- 10560232
- Publisher / Repository:
- Springer Science + Business Media
- Date Published:
- Journal Name:
- Journal of Evolution Equations
- Volume:
- 25
- Issue:
- 1
- ISSN:
- 1424-3199
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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