Understanding neural function requires quantification of the sensory signals that an animal's brain evolved to interpret. These signals in turn depend on the morphology and mechanics of the animal's sensory structures. Although the house mouse (Mus musculus) is one of the most common model species used in neuroscience, the spatial arrangement of its facial sensors has not yet been quantified. To address this gap, the present study quantifies the facial morphology of the mouse, with a particular focus on the geometry of its vibrissae (whiskers). The study develops equations that establish relationships between the three-dimensional (3D) locations of whisker basepoints, whisker geometry (arclength, curvature), and the 3D angles at which the whiskers emerge from the face. Additionally, the positions of facial sensory organs are quantified relative to bregma-lambda. Comparisons with the Norway rat (Rattus norvegicus) indicate that when normalized for head size, the whiskers of these two species have similar spacing density. The rostral-caudal distances between facial landmarks of the rat are a factor of ∼2.1 greater than the mouse, while the scale of bilateral distances is larger and more variable. We interpret these data to suggest that the larger size of rats compared to mice is a derived (apomorphic) trait. As rodents are increasingly important models in behavioral neuroscience, the morphological model developed here will help researchers generate naturalistic, multimodal patterns of stimulation for neurophysiological experiments and allow the generation of synthetic datasets and simulations to close the loop between brain, body, and environment.
Contact-Resistive Sensing of Touch and Airflow Using a Rat Whisker
Rats rely heavily on tactile information from their whiskers to acquire information about their surroundings. A whisker has no sensors along its length. Instead, mechanical deformation of the whisker is sensed via receptors at its base. The present study introduces a micro-sensor developed specifically to imitate the sensing of biological rat whiskers. The sensor responds to bending moments resulting from touch and/or airflow in two axes. The sensor was designed based on analytical models from cantilever beam theory, and the models were validated with finite-element analysis. Sensors were then fabricated using micro-milled molds and integrated into an Arduino-based circuit for simple signal acquisition. The present work begins to develop the technology to allow investigation of important engineering aspects of the rat vibrissal system at 1x scale. In addition to its potential use in novel engineering applications, the sensor could aid neuroscientists in their understanding of the rat vibrissal-trigeminal pathway.
more »
« less
- Award ID(s):
- 1734981
- NSF-PAR ID:
- 10073514
- Date Published:
- Journal Name:
- Proceedings of the ... IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics
- ISSN:
- 2155-1774
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
more » « less
-
null (Ed.)This work presents the design, fabrication, and characterization of an airflow sensor inspired by the whiskers of animals. The body of the whisker was replaced with a fin structure in order to increase the air resistance. The fin was suspended by a micro-fabricated spring system at the bottom. A permanent magnet was attached beneath the spring, and the motion of fin was captured by a readily accessible and low cost 3D magnetic sensor located below the magnet. The sensor system was modeled in terms of the dimension parameters of fin and the spring stiffness, which were optimized to improve the performance of the sensor. The system response was then characterized using a commercial wind tunnel and the results were used for sensor calibration. The sensor was integrated into a micro aerial vehicle (MAV) and demonstrated the capability of capturing the velocity of the MAV by sensing the relative airflow during flight.more » « less
-
We developed a novel whisker-follicle sensor that measures three mechanical signals at the whisker base. The first two signals are closely related to the two bending moments, and the third is an approximation to the axial force. Previous simulation studies have shown that these three signals are sufficient to determine the three-dimensional (3D) location at which the whisker makes contact with an object. Here we demonstrate hardware implementation of 3D contact point determination and then use continuous sweeps of the whisker to show proof-of principle 3D contour extraction. We begin by using simulations to confirm the uniqueness of the mapping between the mechanical signals at the whisker base and the 3D contact point location for the specific dimensions of the hardware whisker. Multi-output random forest regression is then used to predict the contact point locations of objects based on observed mechanical signals. When calibrated to the simulated data, signals from the hardware whisker can correctly predict contact point locations to within 1.5 cm about 74% of the time. However, if normalized output voltages from the hardware whiskers are used to train the algorithm (without calibrating to simulation), predictions improve to within 1.5 cm for about 96% of contact points and to within 0.6 cm for about 78% of contact points. This improvement suggests that as long as three appropriate predictor signals are chosen, calibrating to simulations may not be required. The sensor was next used to perform contour extraction on a cylinder and a cone. We show that basic contour extraction can be obtained with just two sweeps of the sensor. With further sweeps, it is expected that full 3D shape reconstruction could be achieved.more » « less
-
Hydrophobic surfaces provide special characteristics for biomedical applications ranging from tunable protein adsorption, cellular interactions, and hemocompatibility to antibacterial coatings. In this research, we biomimic the hair-like micro-whisker structures of magnolia leaf using a synthetic polymeric formulation. Optical and scanning electron microscopy images revealed the presence of micro-whiskers resulting in higher water contact angles. The top layer of the magnolia leaf had a contact angle of 50º as compared to the hydrophobic bottom layer at 98º. A synthetic polymeric formulation was coated on different materials to study its effect on hydrophobicity. The coating was replicated (n=3) on each of the materials used such as glass, polymer, fabric, wood, and stainless steel. A surface tensiometer was used to measure the transition from hydrophilic to hydrophobic interactions between water and the substrate materials. Contact angle measurements revealed an increase in hydrophobicity for all the materials from their original uncoated surface. Glass displayed the highest increase in contact angle from 37º to 90º. Phase analysis of the coated region was performed to characterize the surface exposure of glass substrate to the synthetic polymeric formulation. An increase in the coated region showed a significant increase in contact angle from 50º to 95º. This research lays the foundation to develop and understand hydrophobic coatings for several biomedical applications including non-fouling implant surfaces, lab-on-chip devices, and other diagnostic tools.more » « less
-
null (Ed.)This work presents the design, modeling, and fabrication of a whisker-like sensor capable of measuring the whisker's angular displacement as well as the applied moments at the base of the whisker. The sensor takes advantage of readily accessible and low-cost 3D magnetic sensors to transduce whisker deflections, and a planar serpentine spring structure at the whisker base is used to provide a mechanical suspension for the whisker to rotate. The sensor prototype was characterized, calibrated, and compared with analytical models of the spring system and the magnetic field. The prototype showed a moment sensing range of 1.1N·mm when deflected up to 19.7°. The sensitivity of the sensor was 0.38°/LSB for the angular displacement sensing, and 0.021 Nmm/LSB for the moment sensing. A fully integrated system is demonstrated to display real-time information from the whisker on a graphical interface.more » « less
- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Conference Paper:
- The DOI is not currently available.
