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Title: A ruthenium–platinum metal complex that binds to sarcin ricin loop RNA and lowers mRNA expression
IT127 is a dinuclear transition metal complex that contains a Pt( ii ) and a Ru( iii ) metal center. We have shown that IT127 is significantly more effective in binding the 29-base sarcin ricin loop (SRL) RNA in comparison to Cisplatin, a hallmark anticancer agent. Binding site analysis shows that IT127 prefers purine bases and the GAGA tetraloop region of SRL RNA. Our results with a dihydrofolate reductase (DHFR) model system reveal that IT127 binding to mRNA reduces translation of DHFR enzyme and that the Ru( iii ) and Pt( ii ) centers in IT127 appear to work in a synergistic manner.
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Chemical Communications
Page Range or eLocation-ID:
8987 to 8990
Sponsoring Org:
National Science Foundation
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