An official website of the United States government
Parameter estimation from observable or experimental data is a crucial stage in any modeling study. Identifiability refers to one’s ability to uniquely estimate the model parameters from the available data. Structural unidentifiability in dynamic models, the opposite of identifiability, is associated with the notion of degeneracy where multiple parameter sets produce the same pattern. Therefore, the inverse function of determining the model parameters from the data is not well defined. Degeneracy is not only a mathematical property of models, but it has also been reported in biological experiments. Classical studies on structural unidentifiability focused on the notion that one can at most identify combinations of unidentifiable model parameters. We have identified a different type of structural degeneracy/unidentifiability present in a family of models, which we refer to as the Lambda-Omega (Λ-Ω) models. These are an extension of the classical lambda-omega (λ-ω) models that have been used to model biological systems, and display a richer dynamic behavior and waveforms that range from sinusoidal to square wave to spike like. We show that the Λ-Ω models feature infinitely many parameter sets that produce identical stable oscillations, except possible for a phase shift (reflecting the initial phase). These degenerate parameters are not identifiable combinations of unidentifiable parameters as is the case in structural degeneracy. In fact, reducing the number of model parameters in the Λ-Ω models is minimal in the sense that each one controls a different aspect of the model dynamics and the dynamic complexity of the system would be reduced by reducing the number of parameters. We argue that the family of Λ-Ω models serves as a framework for the systematic investigation of degeneracy and identifiability in dynamic models and for the investigation of the interplay between structural and other forms of unidentifiability resulting on the lack of information from the experimental/observational data.
more »
« less
Geometrically Motivated Reparameterization for Identifiability Analysis in Power Systems Models
This paper describes a geometric approach to parameter identifiability analysis in models of power systems dynamics. When a model of a power system is to be compared with measurements taken at discrete times, it can be interpreted as a mapping from parameter space into a data or prediction space. Generically, model mappings can be interpreted as manifolds with dimensionality equal to the number of structurally identifiable parameters. Empirically it is observed that model mappings often correspond to bounded manifolds. We propose a new definition of practical identifiability based the topological definition of a manifold with boundary. In many ways, our proposed definition extends the properties of structural identifiability. We construct numerical approximations to geodesics on the model manifold and use the results, combined with insights derived from the mathematical form of the equations, to identify combinations of practically identifiable and unidentifiable parameters. We give several examples of application to dynamic power systems models.
more »
« less
- PAR ID:
- 10101136
- Date Published:
- Journal Name:
- 2018 North American Power Symposium (NAPS)
- Page Range / eLocation ID:
- 1 to 6
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
We extend the sensitivity rank condition (SERC), which tests for identifiability of smooth input-output systems, to a broader class of systems. Particularly, we build on our recently developed lexicographic SERC (L-SERC) theory and methods to achieve an identifiability test for differential-algebraic equation (DAE) systems for the first time, including nonsmooth systems. Additionally, we develop a method to determine the identifiable and non-identifiable parameter sets. We show how this new theory can be used to establish a (non-local) parameter reduction procedure and we show how parameter estimation problems can be solved. We apply the new methods to problems in wind turbine power systems and glucose-insulin kinetics.more » « less
-
Estimation of cardiovascular model parameters from electronic health records (EHRs) poses a significant challenge primarily due to lack of identifiability. Structural non-identifiability arises when a manifold in the space of parameters is mapped to a common output, while practical non-identifiability can result due to limited data, model misspecification or noise corruption. To address the resulting ill-posed inverse problem, optimization-based or Bayesian inference approaches typically use regularization, thereby limiting the possibility of discovering multiple solutions. In this study, we use inVAErt networks, a neural network-based, data-driven framework for enhanced digital twin analysis of stiff dynamical systems. We demonstrate the flexibility and effectiveness of inVAErt networks in the context of physiological inversion of a six-compartment lumped‐parameter haemodynamic model from synthetic data to real data with missing components. This article is part of the theme issue ‘Uncertainty quantification for healthcare and biological systems (Part 2)’.more » « less
-
Differential equation models are crucial to scientific processes across many disciplines, and the values of model parameters are important for analyzing the behaviour of solutions. Identifying these values is known as a parameter estimation, a type of inverse problem, which has applications in areas that include industry, finance and biomedicine. A parameter is called globally identifiable if its value can be uniquely determined from the input and output functions. Checking the global identifiability of model parameters is a useful tool when exploring the well-posedness of a given model. This problem has been intensively studied for ordinary differential equation models, where theory, several efficient algorithms and software packages have been developed. A comprehensive theory for PDEs has hitherto not been developed due to the complexity of initial and boundary conditions. Here, we provide theory and algorithms, based on differential algebra, for testing identifiability of polynomial PDE models. We showcase this approach on PDE models arising in the sciences.more » « less
-
Structural identifiability properties of models of ordinary differential equations help one assess if the parameter's value can be recovered from experimental data. This theoretical property can be queried without the need for data collection and is determined with help of differential algebraic tools. We present a web-based Structural Identifiability Toolbox that rigorously uncovers identifiability properties of individual parameters of ODE systems as well as their functions (also called identifiable combinations) using the apparatus of differential algebra. The application requires no installation and is readily available at https://maple.cloud/app/6509768948056064/more » « less
- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Conference Paper:
- https://doi.org/10.1109/NAPS.2018.8600617
