More Like this

1. Programming the Nucleation of DNA Brick Self‐Assembly with a Seeding Strand

   https://doi.org/10.1002/anie.201915063  

   Zhang, Yingwei; Reinhardt, Aleks; Wang, Pengfei; Song, Jie; Ke, Yonggang (March 2020, Angewandte Chemie International Edition)

   Abstract Recently, the DNA brick strategy has provided a highly modular and scalable approach for the construction of complex structures, which can be used as nanoscale pegboards for the precise organization of molecules and nanoparticles for many applications. Despite the dramatic increase of structural complexity provided by the DNA brick method, the assembly pathways are still poorly understood. Herein, we introduce a “seed” strand to control the crucial nucleation and assembly pathway in DNA brick assembly. Through experimental studies and computer simulations, we successfully demonstrate that the regulation of the assembly pathways through seeded growth can accelerate the assembly kinetics and increase the optimal temperature by circa 4–7 °C for isothermal assembly. By improving our understanding of the assembly pathways, we provide new guidelines for the design of programmable pathways to improve the self‐assembly of DNA nanostructures. 

   more » « less
2. Extending the Brick schema to represent metadata of occupants

   https://doi.org/10.1016/j.autcon.2022.104307  

   Luo, Na; Fierro, Gabe; Liu, Yapan; Dong, Bing; Hong, Tianzhen (July 2022, Automation in Construction)
3. Mass deformations of brane brick models

   https://doi.org/10.1007/JHEP09(2023)176  

   Franco, Sebastián; Ghim, Dongwook; Goulas, Georgios P; Seong, Rak-Kyeong (September 2023, Journal of High Energy Physics)

   A<sc>bstract</sc> We investigate a class of mass deformations that connect pairs of 2d(0,2) gauge theories associated to different toric Calabi-Yau 4-folds. These deformations are generalizations to 2dof the well-known Klebanov-Witten deformation relating the 4dgauge theories for the ℂ²/ℤ₂× ℂ orbifold and the conifold. We investigate various aspects of these deformations, including their connection to brane brick models and the relation between the change in the geometry and the pattern of symmetry breaking triggered by the deformation. We also explore how the volume of the Sasaki-Einstein 7-manifold at the base of the Calabi-Yau 4-fold varies under deformation, which leads us to conjecture that it quantifies the number of degrees of freedom of the gauge theory and its dependence on the RG scale. 

   more » « less
4. Brick: Towards a Unified Metadata Schema For Buildings

   https://doi.org/10.1145/2993422.2993577  

   Balaji, Bharathan; Agarwal, Yuvraj; Berges, Mario; Culler, David; Gupta, Rajesh; Kjærgaard, Mikkel Baun; Srivastava, Mani; Whitehouse, Kamin; Bhattacharya, Arka; Fierro, Gabriel; et al (November 2016, BuildSys '16 Proceedings of the 3rd ACM International Conference on Systems for Energy-Efficient Built Environments)

   Commercial buildings have long since been a primary target for applications from a number of areas: from cyber-physical systems to building energy use to improved human interactions in built environments. While technological advances have been made in these areas, such solutions rarely experience widespread adoption due to the lack of a common descriptive schema which would reduce the now-prohibitive cost of porting these applications and systems to different buildings. Recent attempts have sought to address this issue through data standards and metadata schemes, but fail to capture the set of relationships and entities required by real applications. Building upon these works, this paper describes Brick, a uniform schema for representing metadata in buildings. Our schema defines a concrete ontology for sensors, subsystems and relationships among them, which enables portable applications. We demonstrate the completeness and effectiveness of Brick by using it to represent the entire vendor-specific sensor metadata of six diverse buildings across different campuses, comprising 17,700 data points, and running eight complex unmodified applications on these buildings. 

   more » « less
5. Talking to a Brick Wall: The US Government’s Response to Public Comments on AI

   Aaronson, Susan Ariel (April 2025, Centre for International Governance Innovation)