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Nanoparticle therapeutic delivery is influenced by many factors including physical, chemical, and biophysical properties along with local vascular conditions. In recent years, nanoparticles of various shapes have been fabricated and have shown significant impact on transport efficiency. Identification of which nanoparticle shape helps to improve the therapeutic delivery process allows for enhanced therapeutic effects, yet is hard to be quantified in vivo due to the complex nature of the in vivo environment. In this work, we turn to biological models as a guide for informing improved nanoparticle therapeutic delivery, and quantify the contribution of various factors on delivery efficiency. Here we show that with a mimetic blood vessel, improved therapeutic delivery is achieved using long filamentous rod nanoparticles under low pressure conditions. When considering medium pressure conditions, a combination of nanoparticle shapes presents improved therapeutic delivery over the treatment time-course starting with long filamentous rod nanoparticles, followed by short rod nanoparticles. Conditions of high pressure required a combination of short rod nanoparticles, followed by spherical nanoparticles to achieve enhanced therapeutic delivery. Overall, improvement of therapeutic delivery via nanoparticle carriers is likely to require a combination of nanoparticle shapes administered at different times over the treatment time-course, given patient specific conditions.
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Effects of the magnetodipole corrections on the spectra of spheroidal whispering gallery mode resonators interacting with a dielectric nanoparticle
Interaction between whispering gallery mode (WGM) resonators and nanoparticles is an area of active interest in fundamental understanding of nanoparticle-induced spectral modifications of the WGM resonances in sensing applications. Existing theories of this phenomenon assume that nanoparticles can be described taking into account only the electrodipole contribution to the field of the nanoparticle. In this paper, we explore theoretically the effects of the magnetodipole contribution to the nanoparticle’s field and show that this contribution might become significant even in situations when electrodipole approximation is expected to remain valid.
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- Award ID(s):
- 1711801
- PAR ID:
- 10138080
- Publisher / Repository:
- Optical Society of America
- Date Published:
- Journal Name:
- Optics Letters
- Volume:
- 45
- Issue:
- 6
- ISSN:
- 0146-9592; OPLEDP
- Format(s):
- Medium: X Size: Article No. 1435
- Size(s):
- Article No. 1435
- Sponsoring Org:
- National Science Foundation
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