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Abstract Soft (flexible and stretchable) biosensors have great potential in real-time and continuous health monitoring of various physiological factors, mainly due to their better conformability to soft human tissues and organs, which maximizes data fidelity and minimizes biological interference. Most of the early soft sensors focused on sensing physical signals. Recently, it is becoming a trend that novel soft sensors are developed to sense and monitor biochemical signalsin situin real biological environments, thus providing much more meaningful data for studying fundamental biology and diagnosing diverse health conditions. This is essential to decentralize the healthcare resources towards predictive medicine and better disease management. To meet the requirements of mechanical softness and complex biosensing, unconventional materials, and manufacturing process are demanded in developing biosensors. In this review, we summarize the fundamental approaches and the latest and representative design and fabrication to engineer soft electronics (flexible and stretchable) for wearable and implantable biochemical sensing. We will review the rational design and ingenious integration of stretchable materials, structures, and signal transducers in different application scenarios to fabricate high-performance soft biosensors. Focus is also given to how these novel biosensors can be integrated into diverse important physiological environments and scenariosin situ, such as sweat analysis, wound monitoring, and neurochemical sensing. We also rethink and discuss the current limitations, challenges, and prospects of soft biosensors. This review holds significant importance for researchers and engineers, as it assists in comprehending the overarching trends and pivotal issues within the realm of designing and manufacturing soft electronics for biochemical sensing.
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Soft Electronics for the Skins: from Health Monitors to Human-Machine Interfaces
Conventional bulky and rigid electronics prevents compliant interfacing with soft human skin for health monitoring and human-machine interaction, due to the incompatible mechanical characteristics. To overcome the limitations, soft skin-mountable electronics with superior mechanical softness, flexibility, and stretchability provides an effective platform for intimate interaction with humans. In addition, soft electronics offers comfortability when worn on the soft, curvilinear, and dynamic human skin. In this review, recent advances in soft electronics as health monitors and human-machine interfaces (HMIs) are briefly discussed. Strategies to achieve softness in soft electronics including structural designs, material innovations, and approaches to optimize the interface between human skin and soft electronics are briefly reviewed. Characteristics and performances of soft electronic devices for health monitoring, including temperature sensors, pressure sensors for pulse monitoring, pulse oximeters, electrophysiological sensors, and sweat sensors, exemplify their wide range of utility. Furthermore, we review the soft devices for prosthetic limb, household object, mobile machine, and virtual object control to highlight the current and potential implementations of soft electronics for a broad range of HMI applications. This review concludes with a discussion on the current limitations and future opportunities of soft skin-mountable electronics.
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- Award ID(s):
- 1757949
- PAR ID:
- 10143431
- Date Published:
- Journal Name:
- Advanced materials technologies
- ISSN:
- 2414-4606
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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