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Title: Synthesis of highly water soluble tetrabenzoporphyrins and their application toward photodynamic therapy
Novel tetraaryl-(pyridinium-4-yl)-tetrabenzoporphyrins have been successfully synthesized via a Heck-based sequence reaction. These tetrabenzoporphyrins were substituted with eight pyridyl groups at the fused benzene rings. Methylation of the pyridyl groups with methyl iodide afforded highly water soluble tetrabenzoporphyrins carrying eight ionic groups. The extended [Formula: see text]-conjugation broadened and red-shifted the absorption band of these porphyrins to 650–750 nm. These cationic tetrabenzoporphyrins showed non-toxicity in the dark up to 100 uM. High phototoxicity with IC[Formula: see text] values lower than 18 [Formula: see text]M were obtained for these tetrabenzoporphyrins.  more » « less
Award ID(s):
1800126
PAR ID:
10159188
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Journal of Porphyrins and Phthalocyanines
Volume:
24
Issue:
01n03
ISSN:
1088-4246
Page Range / eLocation ID:
456 to 464
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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