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1. Tensionless AdS3/CFT2 and single trace $$ T\overline{T} $$

   https://doi.org/10.1007/JHEP11(2024)145  

   Dei, Andrea; Knighton, Bob; Naderi, Kiarash; Sethi, Savdeep (November 2024, Journal of High Energy Physics)

   One of the few cases of AdS/CFT where both sides of the duality are under good control relates tensionlessk= 1 strings on AdS₃to a two-dimensional symmetric product CFT. Building on prior observations, we propose an exact duality between string theory on a spacetime which is not asymptotically AdS and a non-conformal field theory. The bulk theory is constructed as a marginal deformation of thek= 1 AdS₃string while the spacetime dual is a single trace$$ T\overline{T} $$ $T\overline{T}$-deformed symmetric orbifold theory. As evidence for the duality, we match the one-loop bulk and boundary torus partition functions. This correspondence provides a framework to both learn about quantum gravity beyond AdS and understand how to define physical observables in$$ T\overline{T} $$ $T\overline{T}$-deformed field theories. 

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2. Cavity-assisted Single-shot T Center Spin Readout

   Wong, Yu-En; Huang, Qiyang; Johnston, Adam; Chen, Songtao (June 2025, Optica Publishing Group)
3. Explicit non-Gorenstein $$R={\mathbb {T}}$$ via rank bounds II: Computational aspects

   https://doi.org/10.1007/s40993-022-00401-1  

   Hsu, Catherine; Wake, Preston; Wang-Erickson, Carl (March 2023, Research in Number Theory)
4. Coercive Fields Above 6 T in Two Cobalt(II)–Radical Chain Compounds

   https://doi.org/10.1002/anie.202002673  

   Liu, Xiaoqing; Feng, Xiaowen; Meihaus, Katie R.; Meng, Xixi; Zhang, Yuan; Li, Liang; Liu, Jun‐Liang; Pedersen, Kasper S.; Keller, Lukas; Shi, Wei; et al (May 2020, Angewandte Chemie International Edition)

   Abstract Lanthanide permanent magnets are widely used in applications ranging from nanotechnology to industrial engineering. However, limited access to the rare earths and rising costs associated with their extraction are spurring interest in the development of lanthanide‐free hard magnets. Zero‐ and one‐dimensional magnetic materials are intriguing alternatives due to their low densities, structural and chemical versatility, and the typically mild, bottom‐up nature of their synthesis. Here, we present two one‐dimensional cobalt(II) systems Co(hfac)₂(R‐NapNIT) (R‐NapNIT=2‐(2′‐(R‐)naphthyl)‐4,4,5,5‐tetramethylimidazoline‐1‐oxyl‐3‐oxide, R=MeO or EtO) supported by air‐stable nitronyl nitroxide radicals. These compounds are single‐chain magnets and exhibit wide, square magnetic hysteresis below 14 K, with giant coercive fields up to 65 or 102 kOe measured using static or pulsed high magnetic fields, respectively. Magnetic, spectroscopic, and computational studies suggest that the record coercivities derive not from three‐dimensional ordering but from the interaction of adjacent chains that compose alternating magnetic sublattices generated by crystallographic symmetry. 

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5. Designed improvement to T-cell immunotherapy by multidimensional single cell profiling

   https://doi.org/10.1136/jitc-2020-001877  

   Bandey, Irfan N; Adolacion, Jay R; Romain, Gabrielle; Paniagua, Melisa Martinez; An, Xingyue; Saeedi, Arash; Liadi, Ivan; You, Zheng; Rajanayake, Rasindu B; Hwu, Patrick; et al (March 2021, Journal for ImmunoTherapy of Cancer)

   null (Ed.)

   Background Adoptive cell therapy based on the infusion of chimeric antigen receptor (CAR) T cells has shown remarkable efficacy for the treatment of hematologic malignancies. The primary mechanism of action of these infused T cells is the direct killing of tumor cells expressing the cognate antigen. However, understanding why only some T cells are capable of killing, and identifying mechanisms that can improve killing has remained elusive. Methods To identify molecular and cellular mechanisms that can improve T-cell killing, we utilized integrated high-throughput single-cell functional profiling by microscopy, followed by robotic retrieval and transcriptional profiling. Results With the aid of mathematical modeling we demonstrate that non-killer CAR T cells comprise a heterogeneous population that arise from failure in each of the discrete steps leading to the killing. Differential transcriptional single-cell profiling of killers and non-killers identified CD137 as an inducible costimulatory molecule upregulated on killer T cells. Our single-cell profiling results directly demonstrate that inducible CD137 is feature of killer (and serial killer) T cells and this marks a different subset compared with the CD107a pos (degranulating) subset of CAR T cells. Ligation of the induced CD137 with CD137 ligand (CD137L) leads to younger CD19 CAR T cells with sustained killing and lower exhaustion. We genetically modified CAR T cells to co-express CD137L, in trans, and this lead to a profound improvement in anti-tumor efficacy in leukemia and refractory ovarian cancer models in mice. Conclusions Broadly, our results illustrate that while non-killer T cells are reflective of population heterogeneity, integrated single-cell profiling can enable identification of mechanisms that can enhance the function/proliferation of killer T cells leading to direct anti-tumor benefit. 

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