More Like this

1. Constant pH Accelerated Molecular Dynamics Investigation of the pH Regulation Mechanism of Dinoflagellate Luciferase

   https://doi.org/10.1021/acs.biochem.7b00873  

   Donnan, Patrick H.; Ngo, Phong D.; Mansoorabadi, Steven O. (January 2018, Biochemistry)
2. Oracle separation of BQP and PH

   https://doi.org/10.1145/3313276.3316315  

   Raz, Ran; Tal, Avishay (January 2019, Proceedings of the 51st Annual ACM SIGACT Symposium on Theory of Computing - STOC 2019)
3. Modeling surface pH measurements of oocytes

   https://doi.org/10.1088/2057-1976/ac71d0  

   Bocchinfuso, A; Calvetti, D; Somersalo, E (June 2022, Biomedical Physics & Engineering Express)

   Abstract The transport of gases across cell membranes plays a key role in many different cell functions, from cell respiration to pH control. Mathematical models play a central role in understanding the factors affecting gas transport through membranes, and are the tool needed for testing the novel hypothesis of the preferential crossing through specific gas channels. Since the surface pH of cell membrane is regulated by the transport of gases such as CO 2 and NH 3 , inferring the membrane properties can be done indirectly from pH measurements. Numerical simulations based on recent models of the surface pH support the hypothesis that the presence of a measurement device, a liquid-membrane pH sensitive electrode on the cell surface may disturb locally the pH, leading to a systematic bias in the measured values. To take this phenomenon into account, it is necessary to equip the model with a description of the micro-environment created by the pH electrode. In this work we propose a novel, computationally lightweight numerical algorithm to simulate the surface pH data. The effect of different parameters of the model on the output are investigated through a series of numerical experiments with a physical interpretation. 

   more » « less
4. Electrochemical Formation of Germanene: pH 4.5

   https://doi.org/10.1149/2.1221707jes  

   Ledina, M. A.; Bui, N.; Liang, X.; Kim, Y. -G.; Jung, J.; Perdue, B.; Tsang, C.; Drnec, J.; Carlà, F.; Soriaga, M. P.; et al (January 2017, Journal of The Electrochemical Society)
5. Optical imaging of dental plaque pH

   Chuqin Huang, Manuja Sharma (April 2020, SPIE Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling)

   Tooth decay is one of the most common chronic infectious diseases worldwide. Bacteria from the oral biofilm create a local acidic environment that demineralizes the enamel in the caries disease process. By optically imaging plaque pH in pits and fissures and contacting surfaces of teeth, then medicinal therapies can be accurately applied to prevent or monitor the reversal of caries. To achieve this goal, the fluorescence emission from an aqueous solution of sodium fluorescein was measured using a multimodal scanning fiber endoscope (mmSFE). The 1.6-millimeter diameter mmSFE scans 424nm laser light and collects wide-field reflectance for navigational purposes in grayscale at 30 Hz. Two fluorescence channels centered at 520 and 549 nm are acquired and ratiometric analysis produces a pseudo-color overlay of pH. In vitro measurements calibrate the pH heat maps in the range 4.7 to 7.2 pH (0.2 standard deviation). In vivo measurements of a single case study provides informative images of interproximal biofilm before and after a sugar rinse. Post processing a time series of images provides a method that calculates the average pH changes of oral biofilm, replicating the Stephan Curve. These spatio-temporal records of oral biofilm pH can provide a new method of assessing the risk of tooth decay, guide the application of preventative therapies, and provide a quantitative monitor of overall oral health. The non-contact in vivo optical imaging of pH may be extended to measurements of wound healing, tumor environment, and other food processing surfaces since it relies on low power laser light and a US FDA approved dye. 

   more » « less