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1. Rapid 1024-pixel Electrochemical Imaging at 10,000 Frames per Second using Monolithic CMOS Sensor and Multifunctional Data Acquisition System

   https://doi.org/10.1109/JSEN.2018.2835829  

   White, Kevin A. ; Mulberry, Geoffrey ; Kim, Brian N. ( May 2018 , IEEE Sensors Journal)

   Fast electrochemical imaging enables the dynamic study of electroactive molecule diffusion in neurotransmitter release from single cells and dopamine mapping in brain slices. In this paper, we discuss the design of an electrochemical imaging sensor using a monolithic CMOS sensor array and a multifunctional data acquisition system. Using post-CMOS fabrication, the CMOS sensor integrates 1024 on-chip electrodes on the surface and contains 1024 low-noise amplifiers to simultaneous process parallel electrochemical recordings. Each electrochemical electrode and amplifier are optimized to operate at 10.38 kHz sampling rate. To support the operation of the high-throughput CMOS device, a multifunctional data acquisition device is developed to provide the required speed and accuracy. The high analog data rate of 10.63 MHz from all 1024 amplifiers is redundantly sampled by the custom-designed data acquisition system which can process up to 73.6 MHz with up to ~400 Mbytes/s data rate to a computer using USB 3.0 interface. To contain the liquid above the electrochemical sensors and prevent electronic and wire damage, we packaged the monolithic sensor using a 3D-printed well. Using the presented device, 32 pixel × 32 pixel electrochemical imaging of dopamine diffusion is successfully demonstrated at over 10,000 frames per second, the fastest reported tomore »date.« less
2. Artifact propagation in electrocorticography stimulation

   Lim, J. ; Wang, P.T. ; Shaw, S.J. ; Armacost, M. ; Gong, H. ; Liu, C.Y. ; Heydari, P. ; Do, A.H. ; Nenadic, Z. ( May 2018 , Seventh International BCI Meeting, Abstract Book)

   Introduction:Current brain-computer interfaces (BCIs) primarily rely on visual feedback. However, visual feedback may not be sufficient for applications such as movement restoration, where somatosensory feedback plays a crucial role. For electrocorticography (ECoG)-based BCIs, somatosensory feedback can be elicited by cortical surface electro-stimulation [1]. However, simultaneous cortical stimulation and recording is challenging due to stimulation artifacts. Depending on the orientation of stimulating electrodes, their distance to the recording site, and the stimulation intensity, these artifacts may overwhelm the neural signals of interest and saturate the recording bioamplifiers, making it impossible to recover the underlying information [2]. To understand how these factors affect artifact propagation, we performed a preliminary characterization of ECoG signals during cortical stimulation.Materials/Methods/ResultsECoG electrodes were implanted in a 39-year old epilepsy patient as shown in Fig. 1. Pairs of adjacent electrodes were stimulated as a part of language cortical mapping. For each stimulating pair, a charge-balanced biphasic square pulse train of current at 50 Hz was delivered for five seconds at 2, 4, 6, 8 and 10 mA. ECoG signals were recorded at 512 Hz. The signals were then high-pass filtered (≥1.5 Hz, zero phase), and the 5-second stimulation epochs were segmented. Within each epoch, artifact-induced peaks were detectedmore »for each electrode, except the stimulating pair, where signals were clipped due to amplifier saturation. These peaks were phase-locked across electrodes and were 20 ms apart, thus matching the pulse train frequency. The response was characterized by calculating the median peak within the 5-second epochs. Fig. 1 shows a representative response of the right temporal grid (RTG), with the stimulation channel at RTG electrodes 14 and 15. It also shows a hypothetical amplifier saturation contour of an implantable, bi-directional, ECoG-based BCI prototype [2], assuming the supply voltage of 2.2 V and a gain of 66 dB. Finally, we quantify the worstcase scenario by calculating the largest distance between the saturation contour and the midpoint of each stimulating channel.Discussion:Our results indicate that artifact propagation follows a dipole potential distribution with the extent of the saturation region (the interior of the white contour) proportional to the stimulation amplitude. In general, the artifacts propagated farthest when a 10 mA current was applied with the saturation regions extending from 17 to 32 mm away from the midpoint of the dipole. Consistent with the electric dipole model, this maximum spread happened along the direction of the dipole moment. An exception occurred at stimulation channel RTG11-16, for which an additional saturation contour emerged away from the dipole contour (not shown), extending the saturation region to 41 mm. Also, the worst-case scenario was observed at 6 mA stimulation amplitude. This departure could be a sign of a nonlinear, switch-like behavior, wherein additional conduction pathways could become engaged in response to sufficiently high stimulation.Significance:While ECoG stimulation is routinely performed in the clinical setting, quantitative studies of the resulting signals are lacking. Our preliminary study demonstrates that stimulation artifacts largely obey dipole distributions, suggesting that the dipole model could be used to predict artifact propagation. Further studies are necessary to ascertain whether these results hold across other subjects and combinations of stimulation/recording grids. Once completed, these studies will reveal practical design constraints for future implantable bi-directional ECoG-based BCIs. These include parameters such as the distances between and relative orientations of the stimulating and recording electrodes, the choice of the stimulating electrodes, the optimal placement of the reference electrode, and the maximum stimulation amplitude. These findings would also have important implications for the design of custom, low-power bioamplifiers for implantable bi-directional ECoG-based BCIs.References:[1] Hiremath, S. V., et al. "Human perception of electrical stimulation on the surface of somatosensory cortex." PloS one 12.5 (2017): e0176020.[2] Rouse, A. G., et al. "A chronic generalized bi-directional brain-machine interface." Journal of Neural Engineering 8.3 (2011): 036018« less
3. Characterization of 2D boron nitride nanosheets with hysteresis effect in the Schottky junctions

   https://doi.org/10.1088/2632-959X/abdf6c  

   Ortiz, Wilber ; Ramirez, Nereida J ; Barrionuevo, Danilo ; Bhattarai, Mohan K ; Feng, Peter ( February 2021 , Nano Express)

   Abstract Carbon doped two-dimensional (2D) hexagonal boron nitride nanosheets (BNNSs) are obtained through a CO 2 —pulsed laser deposition (CO 2 —PLD) technique on silicon dioxide (SiO 2 ) or molybdenum (Mo) substrates, showing - stable hysteresis characteristics over a wide range of temperatures, which makes them a promising candidate for materials based on non-volatile memory devices. This innovative material with electronic properties of n-type characterized in the form of back-to-back Schottky diodes appears to have special features that can enhance the device performance and data retention due to its functional properties, thermal-mechanical stability, and its relation with resistive switching phenomena. It can also be used to eliminate sneak current in resistive random-access memory devices in a crossbar array. In this sense constitutes a good alternative to design two series of resistance-switching Schottky barrier models in the gold/BNNS/gold and gold/BNNS/molybdenum structures; thus, symmetrical and non-symmetrical characteristics are shown at low and high bias voltages as indicated by the electrical current-voltage (I–V) curves. On the one hand, the charge recombination caused by thermionic emission does not significantly change the rectification characteristics of the diode, only its hysteresis properties change due to the increase in external voltage in the Schottky junctions. Themore »addition of carbon to BNNSs creates boron vacancies that exhibit partially ionic character, which also helps to enhance its electrical properties at the metal-BNNS-metal interface.« less
4. A 120-330V, sub-μA, 4-Channel Driver for Microrobotic Actuators with Wireless-Optical Power Delivery and over 99% Current Efficiency

   https://doi.org/10.1109/VLSICircuits18222.2020.9162908  

   Rentmeister, J. S. ; Pister, K. ; Stauth, J. T. ( July 2020 , IEEE Symposium on VLSI Circuits (VLSI))

   This work presents a 4-channel, mm-scale, electrostatic and piezoelectric actuator driver that uses < 1μA total quiescent bias current and can drive actuator loads up to 120-330V at frequencies over 1kHz. The driver achieves over 99% current efficiency and can operate untethered with an integrated photovoltaic array driven by a collimated or diffuse optical power source. The circuit is tested with an off-chip boost circuit, generating over 1.5kV with 85% power efficiency at 45mW load. The system uses a simple 4-bit CMOS logic level interface with 100 kHz clock to actuate high voltage channels; on-chip photovoltaics also power the digital controller, and I/O bus.
5. A 120-330V, sub-µA, optically powered microrobotic drive IC for DARPA SHRIMP

   Rentmeister, J.S ; Pister, K. ; Stauth, J. T. ( April 2020 , GOMACTech 2020)

   This work presents a 4-channel, mm-scale, electro-static and piezoelectric actuator driver that uses< 1 µA total quiescent bias current and can drive actuator loads up to 120-330 V at frequencies over 1kHz. The driver achieves over 99% current efficiency and can operate untethered with an integrated photovoltaic array powered by a collimated or diffuse optical power source. The circuit is demonstrated also as a driver for an off-chip boost circuit, generating over 1.5 kV with 85% power efficiency at 45mW load. The system uses a simple 4-bit CMOS logic level interface with 100 kHz clock to actuate high voltage channels; on-chip photovoltaics also power the digital controller, and I/O bus.