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1. Rapid 1024-pixel Electrochemical Imaging at 10,000 Frames per Second using Monolithic CMOS Sensor and Multifunctional Data Acquisition System

   https://doi.org/10.1109/JSEN.2018.2835829  

   White, Kevin A.; Mulberry, Geoffrey; Kim, Brian N. (May 2018, IEEE Sensors Journal)

   Fast electrochemical imaging enables the dynamic study of electroactive molecule diffusion in neurotransmitter release from single cells and dopamine mapping in brain slices. In this paper, we discuss the design of an electrochemical imaging sensor using a monolithic CMOS sensor array and a multifunctional data acquisition system. Using post-CMOS fabrication, the CMOS sensor integrates 1024 on-chip electrodes on the surface and contains 1024 low-noise amplifiers to simultaneous process parallel electrochemical recordings. Each electrochemical electrode and amplifier are optimized to operate at 10.38 kHz sampling rate. To support the operation of the high-throughput CMOS device, a multifunctional data acquisition device is developed to provide the required speed and accuracy. The high analog data rate of 10.63 MHz from all 1024 amplifiers is redundantly sampled by the custom-designed data acquisition system which can process up to 73.6 MHz with up to ~400 Mbytes/s data rate to a computer using USB 3.0 interface. To contain the liquid above the electrochemical sensors and prevent electronic and wire damage, we packaged the monolithic sensor using a 3D-printed well. Using the presented device, 32 pixel × 32 pixel electrochemical imaging of dopamine diffusion is successfully demonstrated at over 10,000 frames per second, the fastest reported to date. 

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2. High-Speed 1024-Pixel CMOS Electrochemical Imaging Sensor with 40,000 Frames per Second for Dopamine and Hydrogen Peroxide Imaging

   https://doi.org/10.3390/electronics14163207  

   White, Kevin A; Crocker, Matthew A; Kim, Brian N (August 2025, Electronics)

   Electrochemical sensing arrays enable the spatial study of dopamine levels throughout brain slices, the diffusion of electroactive molecules, as well as neurotransmitter secretion from single cells. The integration of complementary metal-oxide semiconductor (CMOS) devices in the development of electrochemical sensing devices enables large-scale parallel recordings, providing beneficial high-throughput for drug screening studies, brain–machine interfaces, and single-cell electrophysiology. In this paper, an electrochemical sensor capable of recording at 40,000 frames per second using a CMOS sensor array with 1024 electrochemical detectors and a custom field-programmable gate array data acquisition system is detailed. A total of 1024 on-chip electrodes are monolithically integrated onto the designed CMOS chip through post-CMOS fabrication. Each electrode is paired with a dedicated transimpedance amplifier, providing 1024 parallel electrochemical sensors for high-throughput studies. To support the level of data generated by the electrochemical device, a powerful data acquisition system is designed to operate the sensor array as well as digitize and transmit the output of the CMOS chip. Using the presented electrochemical sensing system, both dopamine and hydrogen peroxide diffusions across the sensor array are successfully recorded at 40,000 frames per second across the 32 × 32 electrochemical detector array. 

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3. A 120-330V, sub-μA, 4-Channel Driver for Microrobotic Actuators with Wireless-Optical Power Delivery and over 99% Current Efficiency

   https://doi.org/10.1109/VLSICircuits18222.2020.9162908  

   Rentmeister, J. S.; Pister, K.; Stauth, J. T. (July 2020, IEEE Symposium on VLSI Circuits (VLSI))

   This work presents a 4-channel, mm-scale, electrostatic and piezoelectric actuator driver that uses < 1μA total quiescent bias current and can drive actuator loads up to 120-330V at frequencies over 1kHz. The driver achieves over 99% current efficiency and can operate untethered with an integrated photovoltaic array driven by a collimated or diffuse optical power source. The circuit is tested with an off-chip boost circuit, generating over 1.5kV with 85% power efficiency at 45mW load. The system uses a simple 4-bit CMOS logic level interface with 100 kHz clock to actuate high voltage channels; on-chip photovoltaics also power the digital controller, and I/O bus. 

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4. A 120-330V, sub-µA, optically powered microrobotic drive IC for DARPA SHRIMP

   Rentmeister, J.S; Pister, K.; Stauth, J. T. (April 2020, GOMACTech 2020)

   This work presents a 4-channel, mm-scale, electro-static and piezoelectric actuator driver that uses< 1 µA total quiescent bias current and can drive actuator loads up to 120-330 V at frequencies over 1kHz. The driver achieves over 99% current efficiency and can operate untethered with an integrated photovoltaic array powered by a collimated or diffuse optical power source. The circuit is demonstrated also as a driver for an off-chip boost circuit, generating over 1.5 kV with 85% power efficiency at 45mW load. The system uses a simple 4-bit CMOS logic level interface with 100 kHz clock to actuate high voltage channels; on-chip photovoltaics also power the digital controller, and I/O bus. 

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5. Electron transport through a (terpyridine)ruthenium metallo-surfactant containing a redox-active aminocatechol derivative

   https://doi.org/10.1039/D2DT00938B  

   Amunugama, Samudra; Asempa, Eyram; Tripathi, Ramesh Chandra; Wanniarachchi, Dakshika; Baydoun, Habib; Hoffmann, Peter; Jakubikova, Elena; Verani, Cláudio N. (May 2022, Dalton Transactions)

   Aiming to develop a new class of metallosurfactants with unidirectional electron transfer properties, a (terpyridine) ruthenium complex containing a semiquinone derivative L 2 , namely [Ru III (L terpy )(L 2 )Cl]PF 6 (1), was synthesized and structurally characterized as a solid and in solution. The electronic and redox behaviour of 1 was studied experimentally as well as by means of DFT methods, and is indicative of significant orbital mixing and overlap between metal and ligands. The complex forms stable Pockels–Langmuir films at the air-water interface and allows for the formation of thin films onto gold electrodes to prepare nanoscale Au|LB 1|Au junctions for current–voltage ( I / V ) analysis. Complex 1 shows asymmetric electron transfer with a maximum rectification ratio of 32 based on tunnelling through MOs of the aminocatechol derivative. 

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