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The global pandemic of COVID-19 has highlighted the importance of understanding the role that exhaled droplets play in virus transmission in community settings. Computational Fluid Dynamics (CFD) enables systematic examination of roles the exhaled droplets play in the spread of SARS-CoV-2 in indoor environments. This analysis uses published exhaled droplet size distributions combined with terminal aerosol droplet size based on measured peak concentrations for SARS-CoV-2 RNA in aerosols to simulate exhaled droplet dispersion, evaporation, and deposition in a supermarket checkout area and rideshare car where close proximity with other individuals is common. Using air inlet velocity of 2 m/s in the passenger car and ASHRAE recommendations for ventilation and comfort in the supermarket, simulations demonstrate that exhaled droplets <20 μm that contain the majority of viral RNA evaporated leaving residual droplet nuclei that remain aerosolized in the air. Subsequently ~ 70% of these droplet nuclei deposited in the supermarket and the car with the reminder vented from the space. The maximum surface deposition of droplet nuclei/m2for speaking and coughing were 2 and 819, 18 and 1387 for supermarket and car respectively. Approximately 15% of the total exhaled droplets (aerodynamic diameters 20-700 µm) were deposited on surfaces in close proximity to the individual. Due to the non-linear distribution of viral RNA across droplet sizes, however, these larger exhaled droplets that deposit on surfaces have low viral content. Maximum surface deposition of viral RNA was 70 and 1.7 × 103virions/m2for speaking and 2.3 × 104and 9.3 × 104virions/m2for coughing in the supermarket and car respectively while the initial airborne concentration of viral RNA was 7 × 106copies per ml. Integrating the droplet size distributions with viral load distributions, this study helps explain the apparent importance of inhalation exposures compared to surface contact observed in the pandemic.
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Effect of saliva fluid properties on pathogen transmissibility
Abstract With an increasing body of evidence that SARS-CoV-2 is an airborne pathogen, droplet character formed during speech, coughs, and sneezes are important. Larger droplets tend to fall faster and are less prone to drive the airborne transmission pathway. Alternatively, small droplets (aerosols) can remain suspended for long time periods. The small size of SARS-CoV-2 enables it to be encapsulated in these aerosols, thereby increasing the pathogen’s ability to be transmitted via airborne paths. Droplet formation during human respiratory events relates to airspeed (speech, cough, sneeze), fluid properties of the saliva/mucus, and the fluid content itself. In this work, we study the fluidic drivers (fluid properties and content) and their influence on factors relating to transmissibility. We explore the relationship between saliva fluid properties and droplet airborne transmission paths. Interestingly, the natural human response appears to potentially work with these drivers to mitigate pathogen transmission. In this work, the saliva is varied using two approaches: (1) modifying the saliva with colloids that increase the viscosity/surface tension, and (2) stimulating the saliva content to increased/decreased levels. Through modern experimental and numerical flow diagnostic methods, the character, content, and exposure to droplets and aerosols are all evaluated. The results indicate that altering the saliva properties can significantly impact the droplet size distribution, the formation of aerosols, the trajectory of the bulk of the droplet plume, and the exposure (or transmissibility) to droplets. High-fidelity numerical methods used and verify that increased droplet size character enhances droplet fallout. In the context of natural saliva response, we find previous studies indicating natural human responses of increased saliva viscosity from stress and reduced saliva content from either stress or illness. These responses both favorably correspond to reduced transmissibility. Such a finding also relates to potential control methods, hence, we compared results to a surgical mask. In general, we find that saliva alteration can produce fewer and larger droplets with less content and aerosols. Such results indicate a novel approach to alter SARS-CoV-2’s transmission path and may act as a way to control the COVID-19 pandemic, as well as influenza and the common cold.
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- Award ID(s):
- 2031227
- PAR ID:
- 10284797
- Publisher / Repository:
- Nature Publishing Group
- Date Published:
- Journal Name:
- Scientific Reports
- Volume:
- 11
- Issue:
- 1
- ISSN:
- 2045-2322
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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