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This paper presents a framework for reasoning about trustworthiness in cyber-physical systems (CPS) that combines ontology-based reasoning and answer set programming (ASP). It introduces a formal definition of CPS and several problems related to trustworthiness of a CPS such as the problem of identification of the most vulnerable components of the system and of computing a strategy for mitigating an issue. It then shows how a combination of ontology based reasoning and ASP can be used to address the aforementioned problems. The paper concludes with a discussion of the potentials of the proposed methodologies.
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