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   Gutman, Kaylaa L; Quintanilla, Carlos D; Zhang, Liming (February 2024, Journal of the American Chemical Society)

   Enantioselective protonation is a versatile approach to the construction of tertiary α-stereocenters, which are common structural motifs in various natural products and biologically relevant compounds. Herein we report a mild access to these chiral centers using cooperative gold(I) catalysis. From cyclic ketone enol carbonates, this asymmetric catalysis provides highly enantioselective access to cyclic ketones featuring an α tertiary chiral center, including challenging 2-methylsuberone. In combination with the gold-catalyzed formation of cyclopentadienyl carbonates in a one-pot, two-step process, this chemistry enables expedient access to synthetically versatile α′-chiral cyclopentenones with excellent enantiomeric excesses from easily accessible enynyl carbonate substrates. 

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   Cheng, Xinpeng; Zhang, Liming (January 2021, CCS Chemistry)
3. Electrochemical gold redox catalysis for selective oxidative arylation

   https://doi.org/10.1016/j.gresc.2021.01.008  

   Zhang, Shuyao; Ye, Xiaohan; Wojtas, Lukasz; Hao, Wenyan; Shi, Xiaodong (February 2021, Green Synthesis and Catalysis)

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4. Enantioselective Dearomative Cyclization Enabled by Asymmetric Cooperative Gold Catalysis

   https://doi.org/10.1002/anie.202207518  

   Zhao, Ke; Kohnke, Philip; Yang, Ziguang; Cheng, Xinpeng; You, Shu‐Li; Zhang, Liming (August 2022, Angewandte Chemie International Edition)

   Abstract A gold(I)‐catalyzed enantioselective dearomatization is achieved via metal‐chiral ligand cooperation. A new and divergent synthesis of chiral bifunctional binaphthyl‐2‐ylphosphines is developed to allow rapid access to these ligands, which in turn facilitate the application of this chemistry to a broad substrate scope including 1‐naphthols, 2‐naphthols, and phenols. Enantiomeric excesses up to 98 % are achieved via selective acceleration of one enantiomer formation enabled by hydrogen bonding between substrate and ligand remote basic group. DFT calculations lend support to the cooperative catalysis and substantiate the reaction stereochemical outcomes. 

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   https://doi.org/10.1002/chem.201703666  

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