One deadly aspect of COVID-19 is that those infected can often be contagious before exhibiting overt symptoms. While methods such as temperature checks and sinus swabs have aided with early detection, the former does not always provide a reliable indicator of COVID-19, and the latter is invasive and requires significant human and material resources to administer. This paper presents a non-invasive COVID-19 early screening system implementable with commercial off-the-shelf wireless communications devices. The system leverages the Doppler radar principle to monitor respiratory-related chest motion and identifies breathing rates that indicate COVID-19 infection. A prototype was developed from software-defined radios (SDRs) designed for 5G NR wireless communications and system performance was evaluated using a robotic mover simulating human breathing, and using actual breathing, resulting in a consistent respiratory rate accuracy better than one breath per minute, exceeding that used in common medical practice.Clinical Relevance-This establishes the potential efficacy of wireless communications based radar for recognizing respiratory disorders such as COVID-19.
more »
« less
UAV Radar Sensing of Respiratory Variations for COVID-Type Disorders
Unmanned Aerial Vehicles (UAVs) with onboard Doppler radar sensors can be used for health reconnaissance including the remote detection of respiratory patterns associated with COVID-19. While respiratory diagnostics have been demonstrated with radar, the motion of the airborne introduces motion interference. An adaptive filter method is applied here which uses a second radar facing a non-moving surface (ceiling) for a nose cancellation reference signal. Variations in respiratory rate and displacement have been demonstrated which is consistent with the need for detecting tachypnea associated with COVID-19.
more »
« less
- Award ID(s):
- 1915738
- NSF-PAR ID:
- 10295838
- Date Published:
- Journal Name:
- 020 IEEE Asia-Pacific Microwave Conference (APMC)
- Page Range / eLocation ID:
- 737 to 739
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
null (Ed.)Unmanned Aerial Vehicles (UAVs) have demonstrated efficacy as a platform for remote life sensing in post-disaster search and rescue applications. Radar-assisted UAV respiration motion sensing technology also shows promise yet a significant technological challenge remains associated with interfering motion artefacts from the moving UAV platform. The feasibility of integrating an adaptive filter approach for the compensation of platform motion artefacts is investigated here for the extraction of respiratory motion signatures. A 24-GHz dual radar system was attached to a mechanical mover to emulating motion artefacts while measuring the motion of a robotic breathing phantom designed to reproduce breathing motion patterns. Recursive least square (RLS) and a least mean square (LMS) adaptive filter algorithms were employed to test efficacy for extracting respiratory rate from the motion corrupted breathing signal. Experimental results demonstrated that the RLS performed best with an accuracy of 98.24% for extracting the frequency of the robotic breathing phantom mover. The proposed system has several potential applications including military, humanitarian, and post-disaster search and rescue operations.more » « less
-
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the causal agent for COVID-19, is a communicable disease spread through close contact. It is known to disproportionately impact certain communities due to both biological susceptibility and inequitable exposure. In this study, we investigate the most important health, social, and environmental factors impacting the early phases (before July, 2020) of per capita COVID-19 transmission and per capita all-cause mortality in US counties. We aggregate county-level physical and mental health, environmental pollution, access to health care, demographic characteristics, vulnerable population scores, and other epidemiological data to create a large feature set to analyze per capita COVID-19 outcomes. Because of the high-dimensionality, multicollinearity, and unknown interactions of the data, we use ensemble machine learning and marginal prediction methods to identify the most salient factors associated with several COVID-19 outbreak measure. Our variable importance results show that measures of ethnicity, public transportation and preventable diseases are the strongest predictors for both per capita COVID-19 incidence and mortality. Specifically, the CDC measures for minority populations, CDC measures for limited English, and proportion of Black- and/or African-American individuals in a county were the most important features for per capita COVID-19 cases within a month after the pandemic started in a county and also at the latest date examined. For per capita all-cause mortality at day 100 and total to date, we find that public transportation use and proportion of Black- and/or African-American individuals in a county are the strongest predictors. The methods predict that, keeping all other factors fixed, a 10% increase in public transportation use, all other factors remaining fixed at the observed values, is associated with increases mortality at day 100 of 2012 individuals (95% CI [1972, 2356]) and likewise a 10% increase in the proportion of Black- and/or African-American individuals in a county is associated with increases total deaths at end of study of 2067 (95% CI [1189, 2654]). Using data until the end of study, the same metric suggests ethnicity has double the association as the next most important factors, which are location, disease prevalence, and transit factors. Our findings shed light on societal patterns that have been reported and experienced in the U.S. by using robust methods to understand the features most responsible for transmission and sectors of society most vulnerable to infection and mortality. In particular, our results provide evidence of the disproportionate impact of the COVID-19 pandemic on minority populations. Our results suggest that mitigation measures, including how vaccines are distributed, could have the greatest impact if they are given with priority to the highest risk communities.more » « less
-
null (Ed.)Angiotensin-converting enzyme 2 (ACE2) is the cell receptor that the coronavirus SARS-CoV-2 binds to and uses to enter and infect human cells. COVID-19, the pandemic disease caused by the coronavirus, involves diverse pathologies beyond those of a respiratory disease, including micro-thrombosis (micro-clotting), cytokine storms, and inflammatory responses affecting many organ systems. Longer-term chronic illness can persist for many months, often well after the pathogen is no longer detected. A better understanding of the proteins that ACE2 interacts with can reveal information relevant to these disease manifestations and possible avenues for treatment. We have undertaken an approach to predict candidate ACE2 interacting proteins which uses evolutionary inference to identify a set of mammalian proteins that “coevolve” with ACE2. The approach, called evolutionary rate correlation (ERC), detects proteins that show highly correlated evolutionary rates during mammalian evolution. Such proteins are candidates for biological interactions with the ACE2 receptor. The approach has uncovered a number of key ACE2 protein interactions of potential relevance to COVID-19 pathologies. Some proteins have previously been reported to be associated with severe COVID-19, but are not currently known to interact with ACE2, while additional predicted novel ACE2 interactors are of potential relevance to the disease. Using reciprocal rankings of protein ERCs, we have identified strongly interconnected ACE2 associated protein networks relevant to COVID-19 pathologies. ACE2 has clear connections to coagulation pathway proteins, such as Coagulation Factor V and fibrinogen components FGA, FGB, and FGG, the latter possibly mediated through ACE2 connections to Clusterin (which clears misfolded extracellular proteins) and GPR141 (whose functions are relatively unknown). ACE2 also connects to proteins involved in cytokine signaling and immune response ( e.g . XCR1, IFNAR2 and TLR8), and to Androgen Receptor (AR). The ERC prescreening approach has elucidated possible functions for relatively uncharacterized proteins and possible new functions for well-characterized ones. Suggestions are made for the validation of ERC-predicted ACE2 protein interactions. We propose that ACE2 has novel protein interactions that are disrupted during SARS-CoV-2 infection, contributing to the spectrum of COVID-19 pathologies.more » « less
-
more » « less
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected nearly 118 million people and caused ~2.6 million deaths worldwide by early 2021, during the coronavirus disease 2019 (COVID-19) pandemic. Although the majority of infected patients show mild-to-moderate symptoms, a small fraction of patients develops severe symptoms. Uncontrolled cytokine production and the lack of substantive adaptive immune response result in hypoxia, acute respiratory distress syndrome (ARDS), or multiple organ failure in severe COVID-19 patients. Since the current standard of care treatment is insufficient to alleviate severe COVID-19 symptoms, many clinics have been prompted to perform clinical trials involving the infusion of mesenchymal stem cells (MSCs) due to their immunomodulatory and therapeutic properties. Several phases I/II clinical trials involving the infusion of allogenic MSCs have been performed last year. The focus of this review is to critically evaluate the safety and efficacy outcomes of the most recent, placebo-controlled phase I/II clinical studies that enrolled a larger number of patients, in order to provide a statistically relevant and comprehensive understanding of MSC’s therapeutic potential in severe COVID-19 patients. Clinical outcomes obtained from these studies clearly indicate that: (i) allogenic MSC infusion in COVID-19 patients with ARDS is safe and effective enough to decreases a set of inflammatory cytokines that may drive COVID-19 associated cytokine storm, and (ii) MSC infusion efficiently improves COVID-19 patient survival and reduces recovery time. These findings strongly support further investigation into MSC-infusion in larger clinical trials for COVID-19 patients with ARDS, who currently have a nearly 50% of mortality rate.
- Free Publicly Accessible Full Text
-
Accepted Manuscript1.0
- Conference Paper:
- https://doi.org/10.1109/APMC47863.2020.9331613
