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Title: Photochemical synthesis of an epigenetic focused tetrahydroquinoline library
Discovery of epigenetic chemical probes is an important area of research with potential to deliver drugs for a multitude of diseases. However, commercially available libraries frequently used in drug discovery campaigns contain molecules that are focused on a narrow range of chemical space primarily driven by ease of synthesis and previously targeted enzyme classes ( e.g. , kinases) resulting in low hit rates for epigenetic targets. Here we describe the design and synthesis of a compound collection that augments current screening collections by the inclusion of privileged isosteres for epigenetic targets.  more » « less
Award ID(s):
1827457
NSF-PAR ID:
10300459
Author(s) / Creator(s):
;
Date Published:
Journal Name:
RSC Medicinal Chemistry
Volume:
12
Issue:
10
ISSN:
2632-8682
Page Range / eLocation ID:
1780 to 1786
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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