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1. Snapshot multifocal light field microscopy

   https://doi.org/10.1364/OE.390719  

   He, Kuan ; Wang, Xiaolei ; Wang, Zihao W. ; Yi, Hannah ; Scherer, Norbert F. ; Katsaggelos, Aggelos K. ; Cossairt, Oliver ( April 2020 , Optics Express)

   Light field microscopy (LFM) is an emerging technology for high-speed wide-field 3D imaging by capturing 4D light field of 3D volumes. However, its 3D imaging capability comes at a cost of lateral resolution. In addition, the lateral resolution is not uniform across depth in the light field dconvolution reconstructions. To address these problems, here, we propose a snapshot multifocal light field microscopy (MFLFM) imaging method. The underlying concept of the MFLFM is to collect multiple focal shifted light fields simultaneously. We show that by focal stacking those focal shifted light fields, the depth-of-field (DOF) of the LFM can be further improved but without sacrificing the lateral resolution. Also, if all differently focused light fields are utilized together in the deconvolution, the MFLFM could achieve a high and uniform lateral resolution within a larger DOF. We present a house-built MFLFM system by placing a diffractive optical element at the Fourier plane of a conventional LFM. The optical performance of the MFLFM are analyzed and given. Both simulations and proof-of-principle experimental results are provided to demonstrate the effectiveness and benefits of the MFLFM. We believe that the proposed snapshot MFLFM has potential to enable high-speed and high resolution 3D imaging applications.
2. In-situ transfer vat photopolymerization for transparent microfluidic device fabrication

   https://doi.org/10.1038/s41467-022-28579-z  

   Xu, Yang ; Qi, Fangjie ; Mao, Huachao ; Li, Songwei ; Zhu, Yizhen ; Gong, Jingwen ; Wang, Lu ; Malmstadt, Noah ; Chen, Yong ( February 2022 , Nature Communications)

   While vat photopolymerization has many advantages over soft lithography in fabricating microfluidic devices, including efficiency and shape complexity, it has difficulty achieving well-controlled micrometer-sized (smaller than 100 μm) channels in the layer building direction. The considerable light penetration depth of transparent resin leads to over-curing that inevitably cures the residual resin inside flow channels, causing clogs. In this paper, a 3D printing process — in-situ transfer vat photopolymerization is reported to solve this critical over-curing issue in fabricating microfluidic devices. We demonstrate microchannels with highZ-resolution (within 10 μm level) and high accuracy (within 2 μm level) using a general method with no requirements on liquid resins such as reduced transparency nor leads to a reduced fabrication speed. Compared with all other vat photopolymerization-based techniques specialized for microfluidic channel fabrication, our universal approach is compatible with commonly used 405 nm light sources and commercial photocurable resins. The process has been verified by multifunctional devices, including 3D serpentine microfluidic channels, microfluidic valves, and particle sorting devices. This work solves a critical barrier in 3D printing microfluidic channels using the high-speed vat photopolymerization process and broadens the material options. It also significantly advances vat photopolymerization’s use in applications requiring small gaps with high accuracy in theZ-direction.
3. Ultrafast modulation of terahertz waves using on-chip dual-layer near-field coupling

   https://doi.org/10.1364/OPTICA.469461  

   Zhang, Yaxin ; Ding, Kesen ; Zeng, Hongxin ; Kou, Wei ; Zhou, Tianchi ; Zhou, Hongji ; Gong, Sen ; Zhang, Ting ; Wang, Lan ; Liang, Shixiong ; et al ( November 2022 , Optica)

   As a key potential component of future sixth-generation (6G) communication systems, terahertz (THz) technology has received much attention in recent years. However, a lack of effective high-speed direct modulation of THz waves has limited the development of THz communication technology. Currently, most high-speed modulators are based on photonic systems that can modulate electromagnetic waves with high speed using sophisticated optoelectronic conversion techniques. Yet, they usually suffer from low conversion efficiency of light to the THz range, resulting in low output power of the modulated THz waves. Here, we describe a guided-wave modulator for THz signals whose performance nearly matches that of existing in-line fiber-optic modulators. Our results demonstrate a maximum modulation depth greater than 20 dB (99%) and a maximum sinusoidal modulation speed of more than 30 GHz, with an insertion loss around 7 dB. We demonstrate the capabilities of this modulator in a point-to-point communication link with a 25 Gbit/s modulation speed. Our modulator design, based on near-field coupling of a THz transmission line to a single resonant meta-element, represents a powerful improvement for on-chip integrated high-performance THz devices.
4. Deep-learning two-photon fiberscopy for video-rate brain imaging in freely-behaving mice

   https://doi.org/10.1038/s41467-022-29236-1  

   Guan, Honghua ; Li, Dawei ; Park, Hyeon-cheol ; Li, Ang ; Yue, Yuanlei ; Gau, Yung-Tian A. ; Li, Ming-Jun ; Bergles, Dwight E. ; Lu, Hui ; Li, Xingde ( March 2022 , Nature Communications)

   Scanning two-photon (2P) fiberscopes (also termed endomicroscopes) have the potential to transform our understanding of how discrete neural activity patterns result in distinct behaviors, as they are capable of high resolution, sub cellular imaging yet small and light enough to allow free movement of mice. However, their acquisition speed is currently suboptimal, due to opto-mechanical size and weight constraints. Here we demonstrate significant advances in 2P fiberscopy that allow high resolution imaging at high speeds (26 fps) in freely-behaving mice. A high-speed scanner and a down-sampling scheme are developed to boost imaging speed, and a deep learning (DL) algorithm is introduced to recover image quality. For the DL algorithm, a two-stage learning transfer strategy is established to generate proper training datasets for enhancing the quality of in vivo images. Implementation enables video-rate imaging at ~26 fps, representing 10-fold improvement in imaging speed over the previous 2P fiberscopy technology while maintaining a high signal-to-noise ratio and imaging resolution. This DL-assisted 2P fiberscope is capable of imaging the arousal-induced activity changes in populations of layer2/3 pyramidal neurons in the primary motor cortex of freely-behaving mice, providing opportunities to define the neural basis of behavior.
5. Programmable plasmonic phase modulation of free-space wavefronts at gigahertz rates

   Alexei Smolyaninov, Abdelkrim El ( February 2019 , Nature photonics)

   Space-variant control of optical wavefronts is important for many applications in photonics, such as the generation of structured light beams, and is achieved with spatial light modulators. Commercial devices, at present, are based on liquid-crystal and digital micromirror technologies and are typically limited to kilohertz switching speeds. To realize significantly higher operating speeds, new technologies and approaches are necessary. Here we demonstrate two-dimensional control of free-space optical fields at a wavelength of 1,550 nm at a 1 GHz modulation speed using a programmable plasmonic phase modulator based on near-field interactions between surface plasmons and materials with an electrooptic response. High χ(2) and χ(3) dielectric thin films of either aluminium nitride or silicon-rich silicon nitride are used as an active modulation layer in a surface plasmon resonance configuration to realize programmable space-variant control of optical wavefronts in a 4 × 4 pixel array at high speed.