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Title: A measure model for the spread of viral infections with mutations

Genetic variations in the COVID-19 virus are one of the main causes of the COVID-19 pandemic outbreak in 2020 and 2021. In this article, we aim to introduce a new type of model, a system coupled with ordinary differential equations (ODEs) and measure differential equation (MDE), stemming from the classical SIR model for the variants distribution. Specifically, we model the evolution of susceptible \begin{document}$ S $\end{document} and removed \begin{document}$ R $\end{document} populations by ODEs and the infected \begin{document}$ I $\end{document} population by a MDE comprised of a probability vector field (PVF) and a source term. In addition, the ODEs for \begin{document}$ S $\end{document} and \begin{document}$ R $\end{document} contains terms that are related to the measure \begin{document}$ I $\end{document}. We establish analytically the well-posedness of the coupled ODE-MDE system by using generalized Wasserstein distance. We give two examples to show that the proposed ODE-MDE model coincides with the classical SIR model in case of constant or time-dependent parameters as special cases.

Authors:
;
Award ID(s):
2033580
Publication Date:
NSF-PAR ID:
10341804
Journal Name:
Networks and Heterogeneous Media
Volume:
17
Issue:
3
Page Range or eLocation-ID:
427
ISSN:
1556-1801
Sponsoring Org:
National Science Foundation
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