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This work considers the sensitivity of commute travel times in US metro areas due to potential changes in commute patterns, for example caused by events such as pandemics. Permanent shifts away from transit and carpooling can add vehicles to congested road networks, increasing travel times. Growth in the number of workers who avoid commuting and work from home instead can offset travel time increases. To estimate these potential impacts, 6-9 years of American Community Survey commute data for 118 metropolitan statistical areas are investigated. For 74 of the metro areas, the average commute travel time is shown to be explainable using only the number of passenger vehicles used for commuting. A universal Bureau of Public Roads model characterizes the sensitivity of each metro area with respect to additional vehicles. The resulting models are then used to determine the change in average travel time for each metro area in scenarios when 25% or 50% of transit and carpool users switch to single occupancy vehicles. Under a 25% mode shift, areas such as San Francisco and New York that are already congested and have high transit ridership may experience round trip travel time increases of 12 minutes (New York) to 20 minutes (San Francisco), costing individual commuters $1065 and $1601 annually in lost time. The travel time increases and corresponding costs can be avoided with an increase in working from home. The main contribution of this work is to provide a model to quantify the potential increase in commute travel times under various behavior changes, that can aid policy making for more efficient commuting. 

The COVID-19 pandemic lit a fire under researchers who have subsequently raced to build models which capture various physical aspects of both the biology of the virus and its mobility throughout the human population. These models could include characteristics such as different genders, ages, frequency of interactions, mutation of virus, etc. Here, we propose two mathematical formulations to include virus mutation dynamics. The first uses a compartmental epidemiological model coupled with a discrete-time finite-state Markov chain. If one includes a nonlinear dependence of the transition matrix on current infected, the model is able to reproduce pandemic waves due to different variants. The second approach expands such an idea to a continuous state-space leveraging a combination of ordinary differential equations with an evolution equation for measure. This approach allows to include reinfections with partial immunity with respect to variants genetically similar to that of first infection. 

We construct an agent-based SEIR model to simulate COVID-19 spread at a 16000-student mostly non-residential urban university during the Fall 2021 Semester. We find that mRNA vaccine coverage at 100% combined with weekly screening testing of 25% of the campus population make it possible to safely reopen to in-person instruction. Our simulations exhibit a right-skew for total infections over the semester that becomes more pronounced with less vaccine coverage, less vaccine effectiveness and no additional preventative measures. This suggests that high levels of infection are not exceedingly rare with campus social connections the main transmission route. Finally, we find that if vaccine coverage is 100% and vaccine effectiveness is above 80%, then a safe reopening is possible even without facemask use. This models possible future scenarios with high coverage of additional “booster” doses of COVID-19 vaccines. 

Genetic variations in the COVID-19 virus are one of the main causes of the COVID-19 pandemic outbreak in 2020 and 2021. In this article, we aim to introduce a new type of model, a system coupled with ordinary differential equations (ODEs) and measure differential equation (MDE), stemming from the classical SIR model for the variants distribution. Specifically, we model the evolution of susceptible \begin{document}$ S $\end{document} and removed \begin{document}$ R $\end{document} populations by ODEs and the infected \begin{document}$ I $\end{document} population by a MDE comprised of a probability vector field (PVF) and a source term. In addition, the ODEs for \begin{document}$ S $\end{document} and \begin{document}$ R $\end{document} contains terms that are related to the measure \begin{document}$ I $\end{document}. We establish analytically the well-posedness of the coupled ODE-MDE system by using generalized Wasserstein distance. We give two examples to show that the proposed ODE-MDE model coincides with the classical SIR model in case of constant or time-dependent parameters as special cases.

 

The outbreak of COVID-19 resulted in high death tolls all over the world. The aim of this paper is to show how a simple SEIR model was used to make quick predictions for New Jersey in early March 2020 and call for action based on data from China and Italy. A more refined model, which accounts for social distancing, testing, contact tracing and quarantining, is then proposed to identify containment measures to minimize the economic cost of the pandemic. The latter is obtained taking into account all the involved costs including reduced economic activities due to lockdown and quarantining as well as the cost for hospitalization and deaths. The proposed model allows one to find optimal strategies as combinations of implementing various non-pharmaceutical interventions and study different scenarios and likely initial conditions.