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1. FedAT: A High-Performance and Communication-Efficient Federated Learning System with Asynchronous Tiers

   https://doi.org/10.1145/3458817.3476211  

   Chai, Zheng ; Chen, Yujing ; Anwar, Ali ; Zhao, Liang ; Cheng, Yue ; Rangwala, Huzefa ( November 2021 , The International Conference for High Performance Computing, Networking, Storage, and Analysis)

   Federated learning (FL) involves training a model over massive distributed devices, while keeping the training data localized and private. This form of collaborative learning exposes new tradeoffs among model convergence speed, model accuracy, balance across clients, and communication cost, with new challenges including: (1) straggler problem—where clients lag due to data or (computing and network) resource heterogeneity, and (2) communication bottleneck—where a large number of clients communicate their local updates to a central server and bottleneck the server. Many existing FL methods focus on optimizing along only one single dimension of the tradeoff space. Existing solutions use asynchronous model updating or tiering-based, synchronous mechanisms to tackle the straggler problem. However, asynchronous methods can easily create a communication bottleneck, while tiering may introduce biases that favor faster tiers with shorter response latencies. To address these issues, we present FedAT, a novel Federated learning system with Asynchronous Tiers under Non-i.i.d. training data. FedAT synergistically combines synchronous, intra-tier training and asynchronous, cross-tier training. By bridging the synchronous and asynchronous training through tiering, FedAT minimizes the straggler effect with improved convergence speed and test accuracy. FedAT uses a straggler-aware, weighted aggregation heuristic to steer and balance the training across clients for further accuracy improvement. FedAT compresses uplink and downlink communications using an efficient, polyline-encoding-based compression algorithm, which minimizes the communication cost. Results show that FedAT improves the prediction performance by up to 21.09% and reduces the communication cost by up to 8.5×, compared to state-of-the-art FL methods. 

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2. Exploiting Federated Learning Technique to Recognize Human Activities in Resource-Constrained Environment

   Ahmed Imteaj, Raghad Alabagi ( December 2021 , The 13th International Conference on Intelligent Human Computer Interaction (IHCI-2021))

   The conventional machine learning (ML) and deep learning (DL) methods use large amount of data to construct desirable prediction models in a central fusion center for recognizing human activities. However, such model training encounters high communication costs and leads to privacy infringement. To address the issues of high communication overhead and privacy leakage, we employed a widely popular distributed ML technique called Federated Learning (FL) that generates a global model for predicting human activities by combining participated agents’ local knowledge. The state-of-the-art FL model fails to maintain acceptable accuracy when there is a large number of unreliable agents who can infuse false model, or, resource-constrained agents that fails to perform an assigned computational task within a given time window. We developed an FL model for predicting human activities by monitoring agent’s contributions towards model convergence and avoiding the unreliable and resource-constrained agents from training. We assign a score to each client when it joins in a network and the score is updated based on the agent’s activities during training. We consider three mobile robots as FL clients that are heterogeneous in terms of their resources such as processing capability, memory, bandwidth, battery-life and data volume. We consider heterogeneous mobile robots for understanding the effects of real-world FL setting in presence of resource-constrained agents. We consider an agent unreliable if it repeatedly gives slow response or infuses incorrect models during training. By disregarding the unreliable and weak agents, we carry-out the local training of the FL process on selected agents. If somehow, a weak agent is selected and started showing straggler issues, we leverage asynchronous FL mechanism that aggregate the local models whenever it receives a model update from the agents. Asynchronous FL eliminates the issue of waiting for a long time to receive model updates from the weak agents. To the end, we simulate how we can track the behavior of the agents through a reward-punishment scheme and present the influence of unreliable and resource-constrained agents in the FL process. We found that FL performs slightly worse than centralized models, if there is no unreliable and resource-constrained agent. However, as the number of malicious and straggler clients increases, our proposed model performs more effectively by identifying and avoiding those agents while recognizing human activities as compared to the stateof-the-art FL and ML approaches. 

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3. Step-Ahead Error Feedback for Distributed Training with Compressed Gradient

   An Xu, Zhouyuan Huo ( February 2021 , 35th AAAI Conference on Artificial Intelligence (AAAI 2021))

   null (Ed.)

   Although the distributed machine learning methods can speed up the training of large deep neural networks, the communication cost has become the non-negligible bottleneck to constrain the performance. To address this challenge, the gradient compression based communication-efficient distributed learning methods were designed to reduce the communication cost, and more recently the local error feedback was incorporated to compensate for the corresponding performance loss. However, in this paper, we will show that a new "gradient mismatch" problem is raised by the local error feedback in centralized distributed training and can lead to degraded performance compared with full-precision training. To solve this critical problem, we propose two novel techniques, 1) step ahead and 2) error averaging, with rigorous theoretical analysis. Both our theoretical and empirical results show that our new methods can handle the "gradient mismatch" problem. The experimental results show that we can even train faster with common gradient compression schemes than both the full-precision training and local error feedback regarding the training epochs and without performance loss. 

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4. Efficient privacy-preserving machine learning in hierarchical distributed systems

   https://doi.org/10.1109/TNSE.2018.2859420  

   Jia, Qi ; Guo, Lingke ; Fang, Yuguang ; Wang, Guirong ( October 2019 , IEEE transactions on network science and engineering)

   With the dramatic growth of data in both amount and scale, distributed machine learning has become an important tool for the massive data to finish the tasks as prediction, classification, etc. However, due to the practical physical constraints and the potential privacy leakage of data, it is infeasible to aggregate raw data from all data owners or the learning purpose. To tackle this problem, the distributed privacy-preserving learning approaches are introduced to learn over all distributed data without exposing the real information. However, existing approaches have limits on the complicated distributed system. On the one hand, traditional privacy-preserving learning approaches rely on heavy cryptographic primitives on training data, in which the learning speed is dramatically slowed down due to the computation overheads. On the other hand, the complicated system architecture becomes a barrier in the practical distributed system. In this paper, we propose an efficient privacy-preserving machine learning scheme for hierarchical distributed systems. We modify and improve the collaborative learning algorithm. The proposed scheme not only reduces the overhead for the learning process but also provides the comprehensive protection for each layer of the hierarchical distributed system. In addition, based on the analysis of the collaborative convergency in different learning groups, we also propose an asynchronous strategy to further improve the learning efficiency of hierarchical distributed system. At the last, extensive experiments on real-world data are implemented to evaluate the privacy, efficacy, and efficiency of our proposed schemes. 

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5. The Temple University Digital Pathology Corpus: The Breast Tissue Subset

   https://doi.org/10.1109/SPMB52430.2021.9672275  

   Wevodau, Z. ; Doshna, B. ; Jhala, N. ; Akhtar, I. ; Obeid, I. ; Picone, J. ( December 2021 , Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB))

   Obeid, I. (Ed.)

   The Neural Engineering Data Consortium (NEDC) is developing the Temple University Digital Pathology Corpus (TUDP), an open source database of high-resolution images from scanned pathology samples [1], as part of its National Science Foundation-funded Major Research Instrumentation grant titled “MRI: High Performance Digital Pathology Using Big Data and Machine Learning” [2]. The long-term goal of this project is to release one million images. We have currently scanned over 100,000 images and are in the process of annotating breast tissue data for our first official corpus release, v1.0.0. This release contains 3,505 annotated images of breast tissue including 74 patients with cancerous diagnoses (out of a total of 296 patients). In this poster, we will present an analysis of this corpus and discuss the challenges we have faced in efficiently producing high quality annotations of breast tissue. It is well known that state of the art algorithms in machine learning require vast amounts of data. Fields such as speech recognition [3], image recognition [4] and text processing [5] are able to deliver impressive performance with complex deep learning models because they have developed large corpora to support training of extremely high-dimensional models (e.g., billions of parameters). Other fields that do not have access to such data resources must rely on techniques in which existing models can be adapted to new datasets [6]. A preliminary version of this breast corpus release was tested in a pilot study using a baseline machine learning system, ResNet18 [7], that leverages several open-source Python tools. The pilot corpus was divided into three sets: train, development, and evaluation. Portions of these slides were manually annotated [1] using the nine labels in Table 1 [8] to identify five to ten examples of pathological features on each slide. Not every pathological feature is annotated, meaning excluded areas can include focuses particular to these labels that are not used for training. A summary of the number of patches within each label is given in Table 2. To maintain a balanced training set, 1,000 patches of each label were used to train the machine learning model. Throughout all sets, only annotated patches were involved in model development. The performance of this model in identifying all the patches in the evaluation set can be seen in the confusion matrix of classification accuracy in Table 3. The highest performing labels were background, 97% correct identification, and artifact, 76% correct identification. A correlation exists between labels with more than 6,000 development patches and accurate performance on the evaluation set. Additionally, these results indicated a need to further refine the annotation of invasive ductal carcinoma (“indc”), inflammation (“infl”), nonneoplastic features (“nneo”), normal (“norm”) and suspicious (“susp”). This pilot experiment motivated changes to the corpus that will be discussed in detail in this poster presentation. To increase the accuracy of the machine learning model, we modified how we addressed underperforming labels. One common source of error arose with how non-background labels were converted into patches. Large areas of background within other labels were isolated within a patch resulting in connective tissue misrepresenting a non-background label. In response, the annotation overlay margins were revised to exclude benign connective tissue in non-background labels. Corresponding patient reports and supporting immunohistochemical stains further guided annotation reviews. The microscopic diagnoses given by the primary pathologist in these reports detail the pathological findings within each tissue site, but not within each specific slide. The microscopic diagnoses informed revisions specifically targeting annotated regions classified as cancerous, ensuring that the labels “indc” and “dcis” were used only in situations where a micropathologist diagnosed it as such. Further differentiation of cancerous and precancerous labels, as well as the location of their focus on a slide, could be accomplished with supplemental immunohistochemically (IHC) stained slides. When distinguishing whether a focus is a nonneoplastic feature versus a cancerous growth, pathologists employ antigen targeting stains to the tissue in question to confirm the diagnosis. For example, a nonneoplastic feature of usual ductal hyperplasia will display diffuse staining for cytokeratin 5 (CK5) and no diffuse staining for estrogen receptor (ER), while a cancerous growth of ductal carcinoma in situ will have negative or focally positive staining for CK5 and diffuse staining for ER [9]. Many tissue samples contain cancerous and non-cancerous features with morphological overlaps that cause variability between annotators. The informative fields IHC slides provide could play an integral role in machine model pathology diagnostics. Following the revisions made on all the annotations, a second experiment was run using ResNet18. Compared to the pilot study, an increase of model prediction accuracy was seen for the labels indc, infl, nneo, norm, and null. This increase is correlated with an increase in annotated area and annotation accuracy. Model performance in identifying the suspicious label decreased by 25% due to the decrease of 57% in the total annotated area described by this label. A summary of the model performance is given in Table 4, which shows the new prediction accuracy and the absolute change in error rate compared to Table 3. The breast tissue subset we are developing includes 3,505 annotated breast pathology slides from 296 patients. The average size of a scanned SVS file is 363 MB. The annotations are stored in an XML format. A CSV version of the annotation file is also available which provides a flat, or simple, annotation that is easy for machine learning researchers to access and interface to their systems. Each patient is identified by an anonymized medical reference number. Within each patient’s directory, one or more sessions are identified, also anonymized to the first of the month in which the sample was taken. These sessions are broken into groupings of tissue taken on that date (in this case, breast tissue). A deidentified patient report stored as a flat text file is also available. Within these slides there are a total of 16,971 total annotated regions with an average of 4.84 annotations per slide. Among those annotations, 8,035 are non-cancerous (normal, background, null, and artifact,) 6,222 are carcinogenic signs (inflammation, nonneoplastic and suspicious,) and 2,714 are cancerous labels (ductal carcinoma in situ and invasive ductal carcinoma in situ.) The individual patients are split up into three sets: train, development, and evaluation. Of the 74 cancerous patients, 20 were allotted for both the development and evaluation sets, while the remain 34 were allotted for train. The remaining 222 patients were split up to preserve the overall distribution of labels within the corpus. This was done in hope of creating control sets for comparable studies. Overall, the development and evaluation sets each have 80 patients, while the training set has 136 patients. In a related component of this project, slides from the Fox Chase Cancer Center (FCCC) Biosample Repository (https://www.foxchase.org/research/facilities/genetic-research-facilities/biosample-repository -facility) are being digitized in addition to slides provided by Temple University Hospital. This data includes 18 different types of tissue including approximately 38.5% urinary tissue and 16.5% gynecological tissue. These slides and the metadata provided with them are already anonymized and include diagnoses in a spreadsheet with sample and patient ID. We plan to release over 13,000 unannotated slides from the FCCC Corpus simultaneously with v1.0.0 of TUDP. Details of this release will also be discussed in this poster. Few digitally annotated databases of pathology samples like TUDP exist due to the extensive data collection and processing required. The breast corpus subset should be released by November 2021. By December 2021 we should also release the unannotated FCCC data. We are currently annotating urinary tract data as well. We expect to release about 5,600 processed TUH slides in this subset. We have an additional 53,000 unprocessed TUH slides digitized. Corpora of this size will stimulate the development of a new generation of deep learning technology. In clinical settings where resources are limited, an assistive diagnoses model could support pathologists’ workload and even help prioritize suspected cancerous cases. ACKNOWLEDGMENTS This material is supported by the National Science Foundation under grants nos. CNS-1726188 and 1925494. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. REFERENCES [1] N. Shawki et al., “The Temple University Digital Pathology Corpus,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York City, New York, USA: Springer, 2020, pp. 67 104. https://www.springer.com/gp/book/9783030368432. [2] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning.” Major Research Instrumentation (MRI), Division of Computer and Network Systems, Award No. 1726188, January 1, 2018 – December 31, 2021. https://www. isip.piconepress.com/projects/nsf_dpath/. [3] A. Gulati et al., “Conformer: Convolution-augmented Transformer for Speech Recognition,” in Proceedings of the Annual Conference of the International Speech Communication Association (INTERSPEECH), 2020, pp. 5036-5040. https://doi.org/10.21437/interspeech.2020-3015. [4] C.-J. Wu et al., “Machine Learning at Facebook: Understanding Inference at the Edge,” in Proceedings of the IEEE International Symposium on High Performance Computer Architecture (HPCA), 2019, pp. 331–344. https://ieeexplore.ieee.org/document/8675201. [5] I. Caswell and B. Liang, “Recent Advances in Google Translate,” Google AI Blog: The latest from Google Research, 2020. [Online]. Available: https://ai.googleblog.com/2020/06/recent-advances-in-google-translate.html. [Accessed: 01-Aug-2021]. [6] V. Khalkhali, N. Shawki, V. Shah, M. Golmohammadi, I. Obeid, and J. Picone, “Low Latency Real-Time Seizure Detection Using Transfer Deep Learning,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2021, pp. 1 7. https://www.isip. piconepress.com/publications/conference_proceedings/2021/ieee_spmb/eeg_transfer_learning/. [7] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/nsf/mri_dpath/. [8] I. Hunt, S. Husain, J. Simons, I. Obeid, and J. Picone, “Recent Advances in the Temple University Digital Pathology Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2019, pp. 1–4. https://ieeexplore.ieee.org/document/9037859. [9] A. P. Martinez, C. Cohen, K. Z. Hanley, and X. (Bill) Li, “Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ,” Arch. Pathol. Lab. Med., vol. 140, no. 7, pp. 686–689, Apr. 2016. https://doi.org/10.5858/arpa.2015-0238-OA. 

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