Title: To Test or Not to Test: Tools, Rules, and Corporate Data in US Chemicals Regulation
When the Toxic Substances Control Act (TSCA) was passed by the US Congress in 1976, its advocates pointed to new generation of genotoxicity tests as a way to systematically screen chemicals for carcinogenicity. However, in the end, TSCA did not require any new testing of commercial chemicals, including these rapid laboratory screens. In addition, although the Environmental Protection Agency was to make public data about the health effects of industrial chemicals, companies routinely used the agency’s obligation to protect confidential business information to prevent such disclosures. This paper traces the contested history of TSCA and its provisions for testing, from the circulation of the first draft bill in the Nixon administration through the debates over its implementation, which stretched into the Reagan administration. The paucity of publicly available health and environmental data concerning chemicals, I argue, was a by-product of the law and its execution, leading to a situation of institutionalized ignorance, the underside of regulatory knowledge. more »« less
Cohen Hubal, Elaine A.; Reif, David M.; Slover, Rachel; Mullikin, Ashley; Little, John C.
(, International Journal of Environmental Research and Public Health)
null
(Ed.)
Increasing numbers of chemicals are on the market and present in consumer products. Emerging evidence on the relationship between environmental contributions and prevalent diseases suggests associations between early-life exposure to manufactured chemicals and a wide range of children’s health outcomes. Using current assessment methodologies, public health and chemical management decisionmakers face challenges in evaluating and anticipating the potential impacts of exposure to chemicals on children’s health in the broader context of their physical (built and natural) and social environments. Here, we consider a systems approach to address the complexity of children’s environmental health and the role of exposure to chemicals during early life, in the context of nonchemical stressors, on health outcomes. By advancing the tools for integrating this more complex information, the scope of considerations that support chemical management decisions can be extended to include holistic impacts on children’s health.
Arnold, W.A.; Blum, A.; Branyan, J.; Bruton, T.A.; Carignan, C.C.; Cortopassi, G.; Datta, S.; DeWitt, J.; Doherty, A.-C.; Halden, R.U.; et al
(, Environmental science and technology)
Quaternary ammonium compounds (QACs), a large class of chemicals that includes high production volume substances, have been used for decades as antimicrobials, preservatives, and antistatic agents, and for other functions in cleaning, disinfecting, personal care products, and durable consumer goods. QAC use has accelerated in response to the COVID-19 pandemic and the banning of 19 antimicrobials from several personal care products by the US Food and Drug Administration in 2016. Studies conducted before and after the onset of the pandemic indicate increased human exposure to QACs. Environmental releases of these chemicals have also increased. Emerging information on adverse environmental and human health impacts of QACs is motivating a reconsideration of the risks and benefits across the life cycle of their production, use, and disposal. This paper presents a critical review of the literature and scientific perspective developed by a multidisciplinary, multi-institutional team of authors from academia, governmental, and nonprofit organizations. The review evaluates currently available information on the ecological and human health profile of QACs and identifies multiple areas of potential concern. Adverse ecological effects include acute and chronic toxicity to susceptible aquatic organisms, with concentrations of some QACs approaching levels of concern. Suspected or known adverse health outcomes include dermal and respiratory effects, developmental and reproductive toxicity, disruption of metabolic function such as lipid homeostasis, and impairment of mitochondrial function. QACs’ role in antimicrobial resistance has also been demonstrated. In the US regulatory system, how a QAC is managed depends on how it is used, for example, in pesticides or personal care products. This can result in the same QACs receiving different degrees of scrutiny depending on the use and the agency regulating it. Further, the EPA’s current method of grouping QACs based on structure, first proposed in 1988, is insufficient to address the wide range of QAC chemistries, potential toxicities, and exposure scenarios. Consequently, exposures to common mixtures of QACs and from multiple sources remain largely unassessed. Some restrictions on the use of QACs have been implemented in the US and elsewhere, primarily focused on personal care products. Assessing the risks posed by QACs is hampered by their vast structural diversity and a lack of quantitative data on exposure and toxicity for the majority of these compounds. This review identifies important data gaps and provides research and policy recommendations for preserving the utility of QAC chemistries while also seeking to limit adverse environmental and human health effects.
Law, Kara Lavender; Sobkowicz, Margaret J; Shaver, Michael P; Hahn, Mark E
(, Nature Reviews Materials)
A diversity of chemicals are intentionally added to plastics to enhance their properties and aid in manufacture. Yet, the accumulated chemical composition of these materials is essentially unknown even to those within the supply chain, let alone to consumers or recyclers. Recent legislated and voluntary commitments to increase recycled content in plastic products highlight the practical challenges wrought by these chemical mixtures, amid growing public concern about the impacts of plastic-associated chemicals on environmental and human health. In this Perspective, we offer guidance for plastics manufacturers to collaborate across sectors and critically assess their use of added chemicals. The ultimate goal is to use fewer and better additives to promote a circular plastics economy with minimal risk to humans and the environment.
King, Sophie Grace; Bostic, Jonathan David; May, Toni A; Stone, Gregory E
(, Education Sciences)
Testing is a part of education around the world; however, there are concerns that consequences of testing is underexplored within current educational scholarship. Moreover, usability studies are rare within education. One aim of the present study was to explore the usability of a mathematics problem-solving test called the Problem Solving Measures–Computer-Adaptive Test (PSM-CAT) designed for grades six to eight students (ages 11–14). The second aim of this mixed-methods research was to unpack consequences of testing validity evidence related to the results and test interpretations, leveraging the voices of participants. A purposeful, representative sample of over 1000 students from rural, suburban, and urban districts across the USA were administered PSM-CAT followed by a survey. Approximately 100 of those students were interviewed following test administration. Findings indicated that (1) participants engaged in the PSM-CAT as desired and found it highly usable (e.g., most respondents were able to use and find the calculator and several students commented that they engaged with the test as desired) and (2) the benefits from testing largely outweighed any negative outcomes (e.g., 92% of students interviewed had positive attitudes towards the testing experiences), which in turn supports consequences from testing validity evidence for PSM-CAT. This study provides an example of a usability study for educational testing and builds upon previous calls for greater consequences of testing research.
Howerton, Emily; Ferrari, Matthew J.; Bjørnstad, Ottar N.; Bogich, Tiffany L.; Borchering, Rebecca K.; Jewell, Chris P.; Nichols, James D.; Probert, William J.; Runge, Michael C.; Tildesley, Michael J.; et al
(, PLOS Computational Biology)
Flegg, Jennifer A.
(Ed.)
Stay-at-home orders and shutdowns of non-essential businesses are powerful, but socially costly, tools to control the pandemic spread of SARS-CoV-2. Mass testing strategies, which rely on widely administered frequent and rapid diagnostics to identify and isolate infected individuals, could be a potentially less disruptive management strategy, particularly where vaccine access is limited. In this paper, we assess the extent to which mass testing and isolation strategies can reduce reliance on socially costly non-pharmaceutical interventions, such as distancing and shutdowns. We develop a multi-compartmental model of SARS-CoV-2 transmission incorporating both preventative non-pharmaceutical interventions (NPIs) and testing and isolation to evaluate their combined effect on public health outcomes. Our model is designed to be a policy-guiding tool that captures important realities of the testing system, including constraints on test administration and non-random testing allocation. We show how strategic changes in the characteristics of the testing system, including test administration, test delays, and test sensitivity, can reduce reliance on preventative NPIs without compromising public health outcomes in the future. The lowest NPI levels are possible only when many tests are administered and test delays are short, given limited immunity in the population. Reducing reliance on NPIs is highly dependent on the ability of a testing program to identify and isolate unreported, asymptomatic infections. Changes in NPIs, including the intensity of lockdowns and stay at home orders, should be coordinated with increases in testing to ensure epidemic control; otherwise small additional lifting of these NPIs can lead to dramatic increases in infections, hospitalizations and deaths. Importantly, our results can be used to guide ramp-up of testing capacity in outbreak settings, allow for the flexible design of combined interventions based on social context, and inform future cost-benefit analyses to identify efficient pandemic management strategies.
Creager, Angela N. To Test or Not to Test: Tools, Rules, and Corporate Data in US Chemicals Regulation. Retrieved from https://par.nsf.gov/biblio/10397738. Science, Technology, & Human Values 46.5 Web. doi:10.1177/01622439211013373.
Creager, Angela N. To Test or Not to Test: Tools, Rules, and Corporate Data in US Chemicals Regulation. Science, Technology, & Human Values, 46 (5). Retrieved from https://par.nsf.gov/biblio/10397738. https://doi.org/10.1177/01622439211013373
@article{osti_10397738,
place = {Country unknown/Code not available},
title = {To Test or Not to Test: Tools, Rules, and Corporate Data in US Chemicals Regulation},
url = {https://par.nsf.gov/biblio/10397738},
DOI = {10.1177/01622439211013373},
abstractNote = {When the Toxic Substances Control Act (TSCA) was passed by the US Congress in 1976, its advocates pointed to new generation of genotoxicity tests as a way to systematically screen chemicals for carcinogenicity. However, in the end, TSCA did not require any new testing of commercial chemicals, including these rapid laboratory screens. In addition, although the Environmental Protection Agency was to make public data about the health effects of industrial chemicals, companies routinely used the agency’s obligation to protect confidential business information to prevent such disclosures. This paper traces the contested history of TSCA and its provisions for testing, from the circulation of the first draft bill in the Nixon administration through the debates over its implementation, which stretched into the Reagan administration. The paucity of publicly available health and environmental data concerning chemicals, I argue, was a by-product of the law and its execution, leading to a situation of institutionalized ignorance, the underside of regulatory knowledge.},
journal = {Science, Technology, & Human Values},
volume = {46},
number = {5},
author = {Creager, Angela N.},
}
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