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Title: Ionically Complexed Nanoparticles for Heparin Oral Delivery
Ionically complexed nanoparticles were prepared from an anionic polysaccharide drug, heparin, entrapped by a positively charged chitosan polysaccharide. In this study, the encapsulation of heparin was studied to optimize properties needed for its oral drug delivery. Chitosan, used in a variety of biomedical applications, was selected as a cationic polymer for heparin encapsulation. These particles were prepared with a slightly positive charge and an appropriate size for oral drug delivery. The release profiles of these ionically complexed nanoparticles were improved by using FDA approved stabilizers, such as pluronic non-ionic surfactant and polyvinyl alcohol. These results obtained in vitro suggest that these stabilized, ionically complexed nanoparticles may be well-suited for the oral drug delivery of heparin into the gastrointestinal tract.  more » « less
Award ID(s):
1933525
PAR ID:
10435812
Author(s) / Creator(s):
; ; ; ; ; ;
Date Published:
Journal Name:
Precision Nanomedicine
Volume:
5
Issue:
3
ISSN:
2639-9431
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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