More Like this

1. Evolution: Plasticity versus Selection, or Plasticity and Selection?

   https://doi.org/10.1016/j.cub.2018.07.050  

   Perry, Blair W.; Schield, Drew R.; Castoe, Todd A. (September 2018, Current Biology)
2. Micro-plasticity and recent insights from intermittent and small-scale plasticity

   https://doi.org/10.1016/j.actamat.2017.06.023  

   Maaß, R.; Derlet, P.M. (January 2018, Acta Materialia)
3. Nutrigenomic regulation of sensory plasticity

   https://doi.org/10.7554/eLife.83979  

   Sung, Hayeon; Vaziri, Anoumid; Wilinski, Daniel; Woerner, Riley KR; Freddolino, Peter L; Dus, Monica (March 2023, eLife)

   Diet profoundly influences brain physiology, but how metabolic information is transmuted into neural activity and behavior changes remains elusive. Here, we show that the metabolic enzyme O-GlcNAc Transferase (OGT) moonlights on the chromatin of the D. melanogaster gustatory neurons to instruct changes in chromatin accessibility and transcription that underlie sensory adaptations to a high-sugar diet. OGT works synergistically with the Mitogen Activated Kinase/Extracellular signal Regulated Kinase (MAPK/ERK) rolled and its effector stripe (also known as EGR2 or Krox20) to integrate activity information. OGT also cooperates with the epigenetic silencer Polycomb Repressive Complex 2.1 (PRC2.1) to decrease chromatin accessibility and repress transcription in the high-sugar diet. This integration of nutritional and activity information changes the taste neurons’ responses to sugar and the flies’ ability to sense sweetness. Our findings reveal how nutrigenomic signaling generates neural activity and behavior in response to dietary changes in the sensory neurons. 

   more » « less
4. Acoustic profiling of intermittent plasticity

   https://doi.org/10.1016/j.actamat.2024.120646  

   Omar, Mostafa M; El-Awady, Jaafar A (February 2025, Acta Materialia)
5. Epigenetics and the maintenance of developmental plasticity: extending the signalling theory framework: Epigenetics and phenotypic plasticity

   https://doi.org/10.1111/brv.12396  

   Laubach, Zachary M.; Perng, Wei; Dolinoy, Dana C.; Faulk, Christopher D.; Holekamp, Kay E.; Getty, Thomas (August 2018, Biological Reviews)