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   https://doi.org/10.1364/OL.500033  

   Shen, Jianhao; Donnelly, Daniel; Chakravarty, Swapnajit (November 2023, Optics Letters)

   We experimentally demonstrated slow-wave-enhanced phase and spectral sensitivity in asymmetric Michelson interferometer (MI) sensors. Compared to Mach–Zehnder interferometers (MZI) that experimentally demonstrated a phase sensitivity of 84,000 rad/RIU-cm, the reflected path enhancement of the optical path length coupled with slow light enhancement with photonic crystal waveguides in on-chip slow light Michelson interferometer sensors resulted in experimentally demonstrated phase sensitivity of 277,750 rad/RIU-cm with theoretical phase sensitivity as high as 461,810 rad/RIU-cm, at the same form factor as the MZI of identical interferometer arm lengths. 

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2. High-Speed Multidimensional Optical Computing

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   Fardoost, Alireza; Vanani, Fatemeh Ghaedi; Zhu, Zheyuan; Doerr, Christopher; Pang, Shuo; Li, Guifang (October 2023, Optica Publishing Group)

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4. A Bioluminescent Protein‐Graphene Oxide Donor‐Quencher Pair in DNA Hybridization Assays

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   Abstract Despite fluorescent quenching with graphene oxide (GO) having shown great success in various applications ‐ bioluminescent quenching has not yet been demonstrated using GO as a quencher. To explore the ability of GO to quench bioluminescence, we usedGaussialuciferase (Gluc) as a donor and GO as a quencher and demonstrated its application in sensing of two target analytes, HIV‐1 DNA and IFN‐γ. We demonstrated that the incubation of Gluc conjugated HIV‐1 and IFN‐γ oligonucleotide probes with GO provided for monitoring of probe‐target interactions based on bioluminescence measurement in a solution phase sensing system. The limits of detection obtained for IFN‐γ and HIV‐1 DNA detection were 17 nM and 7.59 nM, respectively. Both sensing systems showed selectivity toward the target analyte. The detection of IFN‐γ in saliva matrix was demonstrated. The use of GO as a quencher provides for high sensitivity while maintaining the selectivity of designed probes to their respective targets. The use of GO as a quencher provides for an easy assay design and low cost, environmentally friendly reporter. 

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5. A Review of Optical Flow Velocimetry in Fluid Mechanics

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   Abstract Optical flow methods have been developed over the past two decades for application to PIV images with the goal of acquiring higher resolution measurements of the velocity field than conventional cross-correlation-based techniques. Numerous optical flow velocimetry (OFV) algorithms have been devised to solve the ill-posed optical flow problem, with various physics-inspired strategies to tailor them to fluid flows. While OFV can be applied to continuous scalar fields, it has demonstrated the most success on images of tracer particles, i.e.\ traditional planar PIV images. Compared to state-of-the-art cross-correlation algorithms, OFV methods have demonstrated an order of magnitude increase in spatial resolution and up to a factor of two improvement in overall accuracy when evaluated on synthetic data, at the cost of increased computational time. The requirements for particle seeding density, inter-frame displacement, and image quality are also more stringent for OFV methods compared to cross-correlation. OFV has been applied sparingly in experiments to date, but appears to offer the same advantages demonstrated on synthetic data. At this stage, OFV seems best suited to planar velocity measurements, although extensions to stereoscopic measurements have been demonstrated. 

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