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1. Brain and Behavior in Engineering Design: An Exploratory Study on Using Concept Mapping

   https://doi.org/10.1007/978-3-031-20418-0_13  

   Hu, M.; Shealy, T.; Gero, J.; Milovanovic, J.; Ignacio Jr, P. (April 2023, Design Computing and Cognition'22)

   Gero, John S. (Ed.)

   To explore the connection between brain and behavior in engineering design, this study measured the change in neurocognition of engineering students while they developed concept maps. Concept maps help designers organize complex ideas by illustrating components and relationships. Student concept maps were graded using a pre-established scoring method and compared to their neurocognitive activation. Results show significant correlations between performance and neurocognition. Concept map scores were positively correlated with activation in students’ prefrontal cortex. A prominent sub-region was the right dorsolateral prefrontal cortex (DLPFC), which is generally associated with divergent thinking and cognitive flexibility. Student scores were negatively correlated with measures of brain network density. The findings suggest a possible neurocognitive mechanism for better performance. More research is needed to connect brain activation to the cognitive activi-ies that occur when designing but these results provide new evidence for the brain functions that support the development of complex ideas during design. 

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2. Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents

   https://doi.org/10.1126/scitranslmed.abm5868  

   Sun, Guanghao; Zeng, Fei; McCartin, Michael; Zhang, Qiaosheng; Xu, Helen; Liu, Yaling; Chen, Zhe Sage; Wang, Jing (June 2022, Science Translational Medicine)

   Pain relief on-demand Chronic pain is a debilitating condition for which there are no effective treatments. The primary somatosensory cortex (S1) and the anterior cingulate cortex (ACC) are involved in decoding pain components, and electrical stimulation of the prefrontal cortex (PFC) has been shown to exert analgesic effects. Here, Sun et al. developed a multiregion brain-machine interface (BMI) able to detect pain from electrical signals in S1 and ACC and provide on-demand PFC stimulation. The BMI was able to accurately detect and treat acute and chronic pain in rats; the analgesic effects were stable over time. The results suggest that BMI approaches might be effective for treating chronic pain of different etiologies. 

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3. Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity

   https://doi.org/10.1038/s41398-023-02625-w  

   Sun, Sai; Yu, Hongbo; Yu, Rongjun; Wang, Shuo (December 2023, Translational Psychiatry)

   Abstract Processing facial expressions of emotion draws on a distributed brain network. In particular, judging ambiguous facial emotions involves coordination between multiple brain areas. Here, we applied multimodal functional connectivity analysis to achieve network-level understanding of the neural mechanisms underlying perceptual ambiguity in facial expressions. We found directional effective connectivity between the amygdala, dorsomedial prefrontal cortex (dmPFC), and ventromedial PFC, supporting both bottom-up affective processes for ambiguity representation/perception and top-down cognitive processes for ambiguity resolution/decision. Direct recordings from the human neurosurgical patients showed that the responses of amygdala and dmPFC neurons were modulated by the level of emotion ambiguity, and amygdala neurons responded earlier than dmPFC neurons, reflecting the bottom-up process for ambiguity processing. We further found parietal-frontal coherence and delta-alpha cross-frequency coupling involved in encoding emotion ambiguity. We replicated the EEG coherence result using independent experiments and further showed modulation of the coherence. EEG source connectivity revealed that the dmPFC top-down regulated the activities in other brain regions. Lastly, we showed altered behavioral responses in neuropsychiatric patients who may have dysfunctions in amygdala-PFC functional connectivity. Together, using multimodal experimental and analytical approaches, we have delineated a neural network that underlies processing of emotion ambiguity. 

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4. Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization

   https://doi.org/10.1523/JNEUROSCI.2343-23.2024  

   Broschard, Matthew_B; Turner, Brandon_M; Tranel, Daniel; Freeman, John_H (July 2024, The Journal of Neuroscience)

   Models of human categorization predict the prefrontal cortex (PFC) serves a central role in category learning. The dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC) have been implicated in categorization; however, it is unclear whether both are critical for categorization and whether they support unique functions. We administered three categorization tasks to patients with PFC lesions (mean age, 69.6 years; 5 men, 5 women) to examine how the prefrontal subregions contribute to categorization. These included a rule-based (RB) task that was solved via a unidimensional rule, an information integration (II) task that was solved by combining information from two stimulus dimensions, and a deterministic/probabilistic (DP) task with stimulus features that had varying amounts of category-predictive information. Compared with healthy comparison participants, both patient groups had impaired performance. Impairments in the dlPFC patients were largest during the RB task, whereas impairments in the vmPFC patients were largest during the DP task. A hierarchical model was fit to the participants’ data to assess learning deficits in the patient groups. PFC damage was correlated with a regularization term that limited updates to attention after each trial. Our results suggest that the PFC, as a whole, is important for learning to orient attention to relevant stimulus information. The dlPFC may be especially important for rule-based learning, whereas the vmPFC may be important for focusing attention on deterministic (highly diagnostic) features and ignoring less predictive features. These results support overarching functions of the dlPFC in executive functioning and the vmPFC in value-based decision-making. 

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5. A new measure for team performance: Measuring inter-brain synchrony of engineering students when designing and building

   Aruon, A.; Shealy, T.; Gero, J. (June 2023, Engineering project organization journal)

   This research paper examines the patterns of inter-brain synchrony among engineering student teams and the relationship between inter-brain synchrony and team cooperation and performance. A pilot study was conducted with eight two-person teams of fourth-year undergraduate civil engineering students. Three collaborative design and build tasks were assigned to each team. Two independent raters carried out the behavioral analysis, scoring team cooperation. Each team member wore a functional near-infrared spectroscopy (fNIRS) device to measure inter-brain synchrony during the tasks. The results showed that inter-brain synchrony occurred during the team task, but the patterns varied between groups and tasks. Elevated levels of inter-brain synchrony were observed in the left ventrolateral prefrontal cortex (VLPFC) and left dorsolateral prefrontal cortex (DLPFC). The left VLPFC and left DLPFC are often associated with cognitive processes such as problem-solving, working memory, decision-making, and coordinated verbal exchange. Inter-brain synchrony was positively correlated with task performance and cooperation when teams were asked to design and build a structure given limited time and money but negatively correlated with cooperation and performance on other more open-ended design sketching tasks. The study’s findings suggest that inter-brain synchrony exists when engineering students work together as a team, but the results are inconsistent between task types. Inter-brain synchrony could be a useful metric for measuring team cooperation and performance, particularly in tasks that require coordinated verbal exchange, problemsolving, and decision-making. However, the study’s small sample size limits the generalizability of the results. Future studies with a larger sample size and more diverse groups of engineers are needed to validate the findings and explore their implications further. 

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