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1. High‐definition transcranial direct current stimulation dissociates fronto‐visual theta lateralization during visual selective attention

   https://doi.org/10.1113/JP278788  

   Spooner, Rachel K. ; Eastman, Jacob A. ; Rezich, Michael T. ; Wilson, Tony W. ( February 2020 , The Journal of Physiology)

   Visual attention involves discrete multispectral oscillatory responses in visual and ‘higher‐order’ prefrontal cortices.

   Prefrontal cortex laterality effects during visual selective attention are poorly characterized.

   High‐definition transcranial direct current stimulation dynamically modulated right‐lateralized fronto‐visual theta oscillations compared to those observed in left fronto‐visual pathways.

   Increased connectivity in right fronto‐visual networks after stimulation of the left dorsolateral prefrontal cortex resulted in faster task performance in the context of distractors.

   Our findings show clear laterality effects in theta oscillatory activity along prefrontal–visual cortical pathways during visual selective attention.

   Studies of visual attention have implicated oscillatory activity in the recognition, protection and temporal organization of attended representations in visual cortices. These studies have also shown that higher‐order regions such as the prefrontal cortex are critical to attentional processing, but far less is understood regarding prefrontal laterality differences in attention processing. To examine this, we selectively applied high‐definition transcranial direct current stimulation (HD‐tDCS) to the left or right dorsolateral prefrontal cortex (DLPFC). We predicted that HD‐tDCS of the leftversusright prefrontal cortex would differentially modulate performance on a visual selective attention task, and alter the underlying oscillatory network dynamics. Our randomized crossover design included 27 healthy adults that underwent three separate sessions of HD‐tDCS (sham, left DLPFC and right DLPFC) for 20 min. Following stimulation, participants completed an attention protocol during magnetoencephalography. The resulting oscillatory dynamics were imaged using beamforming, and peak task‐related neural activity was subjected to dynamic functional connectivity analyses to evaluate the impact of stimulation site (i.e. left and right DLPFC) on neural interactions. Our results indicated that HD‐tDCS over the left DLPFC differentially modulated right fronto‐visual functional connectivity within the theta band compared to HD‐tDCS of the right DLPFC and further, specifically modulated the oscillatory response for detecting targets among an array of distractors. Importantly, these findings provide network‐specific insight into the complex oscillatory mechanisms serving visual selective attention.

    

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2. Multielectrode Transcranial Electrical Stimulation of the Left and Right Prefrontal Cortices Differentially Impacts Verbal Working Memory Neural Circuitry

   https://doi.org/10.1093/cercor/bhz246  

   Koshy, Sam M. ; Wiesman, Alex I. ; Spooner, Rachel K. ; Embury, Christine ; Rezich, Michael T. ; Heinrichs-Graham, Elizabeth ; Wilson, Tony W. ( December 2019 , Cerebral Cortex)

   Recent studies have examined the effects of conventional transcranial direct current stimulation (tDCS) on working memory (WM) performance, but this method has relatively low spatial precision and generally involves a reference electrode that complicates interpretation. Herein, we report a repeated-measures crossover study of 25 healthy adults who underwent multielectrode tDCS of the left dorsolateral prefrontal cortex (DLPFC), right DLPFC, or sham in 3 separate visits. Shortly after each stimulation session, participants performed a verbal WM (VWM) task during magnetoencephalography, and the resulting data were examined in the time–frequency domain and imaged using a beamformer. We found that after left DLPFC stimulation, participants exhibited stronger responses across a network of left-lateralized cortical areas, including the supramarginal gyrus, prefrontal cortex, inferior frontal gyrus, and cuneus, as well as the right hemispheric homologues of these regions. Importantly, these effects were specific to the alpha-band, which has been previously implicated in VWM processing. Although stimulation condition did not significantly affect performance, stepwise regression revealed a relationship between reaction time and response amplitude in the left precuneus and supramarginal gyrus. These findings suggest that multielectrode tDCS targeting the left DLPFC affects the neural dynamics underlying offline VWM processing, including utilization of a more extensive bilateral cortical network.

    

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3. Altered Neural Correlates of Emotion Associated Pain Processing in Persistent Somatoform Pain Disorder: An fMRI Study

   https://doi.org/10.1111/papr.12358  

   Luo, Yanli ; Yan, Chao ; Huang, Tianming ; Fan, Mingxia ; Liu, Liang ; Zhao, Zhiyong ; Ni, Kaiji ; Jiang, Hong ; Huang, Xiao ; Lu, Zheng ; et al ( September 2016 , Pain Practice)

   Patients with persistent somatoform pain disorder (PSPD) suffer from long‐term pain and emotional conflicts. Recently, accumulating evidence indicated that emotion has a significant role in pain perception of somatoform pain disorder. To further understand the association between emotion and pain‐related brain activities, functional activities of patients with PSPD fulfilling ICD‐10 criteria and healthy controls were assessed using functional magnetic resonance imaging technology, while participants viewed a series of positive, neutral, or negative pictures with or without pinprick pain stimulation. Results showed that patients with PSPD had altered brain activities in the parietal gyrus, temporal gyrus, posterior cingulate cortex, prefrontal cortex, and parahippocampus in response to pinprick pain stimuli during different emotions compared with the healthy control group. Moreover, patients with PSPD consistently showed hyperactivities in the prefrontal, the fusiform gyrus and the insula in response to negative stimuli under pinprick pain vs. non‐pain condition. The current findings provide some insights into the underlying relationship between emotion and pain‐related brain activity in patients with PSPD, which is of both theoretical and clinical importance.

    

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4. Microstructural integrity of white matter moderates an association between childhood adversity and adult trait anger

   https://doi.org/10.1002/ab.21820  

   Kim, M. Justin ; Elliott, Maxwell L. ; d'Arbeloff, Tracy C. ; Knodt, Annchen R. ; Radtke, Spenser R. ; Brigidi, Bartholomew D. ; Hariri, Ahmad R. ( January 2019 , Aggressive Behavior)

   Amongst a number of negative life sequelae associated with childhood adversity is the later expression of a higher dispositional tendency to experience anger and frustration to a wide range of situations (i.e., trait anger). We recently reported that an association between childhood adversity and trait anger is moderated by individual differences in both threat‐related amygdala activity and executive control‐related dorsolateral prefrontal cortex (dlPFC) activity, wherein individuals with relatively low amygdala and high dlPFC activity do not express higher trait anger even when having experienced childhood adversity. Here, we examine possible structural correlates of this functional dynamic using diffusion magnetic resonance imaging data from 647 young adult men and women volunteers. Specifically, we tested whether the degree of white matter microstructural integrity as indexed by fractional anisotropy modulated the association between childhood adversity and trait anger. Our analyses revealed that higher microstructural integrity of multiple pathways was associated with an attenuated link between childhood adversity and adult trait anger. Amongst these pathways was the uncinate fasciculus (UF; ΔR² = 0.01), which not only provides a major anatomical link between the amygdala and prefrontal cortex but also is associated with individual differences in regulating negative emotion through top‐down cognitive reappraisal. These findings suggest that higher microstructural integrity of distributed white matter pathways including but not limited to the UF may represent an anatomical foundation serving to buffer against the expression of childhood adversity as later trait anger, which is itself associated with multiple negative health outcomes.

    

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5. Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents

   https://doi.org/10.1126/scitranslmed.abm5868  

   Sun, Guanghao ; Zeng, Fei ; McCartin, Michael ; Zhang, Qiaosheng ; Xu, Helen ; Liu, Yaling ; Chen, Zhe Sage ; Wang, Jing ( June 2022 , Science Translational Medicine)

   Pain relief on-demand Chronic pain is a debilitating condition for which there are no effective treatments. The primary somatosensory cortex (S1) and the anterior cingulate cortex (ACC) are involved in decoding pain components, and electrical stimulation of the prefrontal cortex (PFC) has been shown to exert analgesic effects. Here, Sun et al. developed a multiregion brain-machine interface (BMI) able to detect pain from electrical signals in S1 and ACC and provide on-demand PFC stimulation. The BMI was able to accurately detect and treat acute and chronic pain in rats; the analgesic effects were stable over time. The results suggest that BMI approaches might be effective for treating chronic pain of different etiologies. 

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