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Title: Janus Paper‐Based Wound Dressings for Effective Exudate Absorption and Antibiotic Delivery
Traditional hydrophilic wound dressings, while common, fail to effectively drain wound exudate, creating conditions favorable for bacterial growth. Similarly, newer Janus‐type dressings with hydrophobic‐hydrophilic properties also fall short, as their hydrophobic side causes excessive dryness by pulling biofluids from the wound, disrupting moisture balance. Additionally, embedding antibiotics in dressings at fixed concentrations, regardless of the infection type, reduces effectiveness and contributes to the growing problem of antibiotic resistance. In response, a single‐layered Janus paper wound dressing, designed for efficient exudate absorption and precise antibiotic delivery, is developed. The approach differs from traditional Janus‐type dressings; a hydrophilic layer is placed directly against the wound for better moisture management, while antibiotics are applied through the hydrophobic layer. To further enhance exudate management, the hydrophilic section with four extra absorbent pads is extended. The dressing's antibiotic efficacy and dosage are tailored based on antibiotic susceptibility testing, ensuring targeted treatment. The selected antibiotic is manually added but automatically delivered directly to the wound bed. The in vitro and ex vivo evaluations, using bacterial cultures on agar and porcine skin assays, respectively, confirm the dressing's superior exudate drainage and its ability to inhibit pathogen growth and reproduction, marking a significant advancement in wound care.  more » « less
Award ID(s):
2100757 2246975
PAR ID:
10482067
Author(s) / Creator(s):
 ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Advanced Engineering Materials
Volume:
26
Issue:
5
ISSN:
1438-1656
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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