Abstract Propensity score weighting is a tool for causal inference to adjust for measured confounders in observational studies. In practice, data often present complex structures, such as clustering, which make propensity score modeling and estimation challenging. In addition, for clustered data, there may be unmeasured cluster-level covariates that are related to both the treatment assignment and outcome. When such unmeasured cluster-specific confounders exist and are omitted in the propensity score model, the subsequent propensity score adjustment may be biased. In this article, we propose a calibration technique for propensity score estimation under the latent ignorable treatment assignment mechanism, i. e., the treatment-outcome relationship is unconfounded given the observed covariates and the latent cluster-specific confounders. We impose novel balance constraints which imply exact balance of the observed confounders and the unobserved cluster-level confounders between the treatment groups. We show that the proposed calibrated propensity score weighting estimator is doubly robust in that it is consistent for the average treatment effect if either the propensity score model is correctly specified or the outcome follows a linear mixed effects model. Moreover, the proposed weighting method can be combined with sampling weights for an integrated solution to handle confounding and sampling designs for causal inference with clustered survey data. In simulation studies, we show that the proposed estimator is superior to other competitors. We estimate the effect of School Body Mass Index Screening on prevalence of overweight and obesity for elementary schools in Pennsylvania.
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Soft calibration for selection bias problems under mixed-effects models
Abstract Calibration weighting has been widely used to correct selection biases in nonprobability sampling, missing data and causal inference. The main idea is to calibrate the biased sample to the benchmark by adjusting the subject weights. However, hard calibration can produce enormous weights when an exact calibration is enforced on a large set of extraneous covariates. This article proposes a soft calibration scheme, where the outcome and the selection indicator follow mixed-effect models. The scheme imposes an exact calibration on the fixed effects and an approximate calibration on the random effects. On the one hand, our soft calibration has an intrinsic connection with best linear unbiased prediction, which results in a more efficient estimation compared to hard calibration. On the other hand, soft calibration weighting estimation can be envisioned as penalized propensity score weight estimation, with the penalty term motivated by the mixed-effect structure. The asymptotic distribution and a valid variance estimator are derived for soft calibration. We demonstrate the superiority of the proposed estimator over other competitors in simulation studies and using a real-world data application on the effect of BMI screening on childhood obesity.
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- Award ID(s):
- 1931380
- PAR ID:
- 10491690
- Publisher / Repository:
- Biometrika
- Date Published:
- Journal Name:
- Biometrika
- Volume:
- 110
- Issue:
- 4
- ISSN:
- 0006-3444
- Page Range / eLocation ID:
- 897 to 911
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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