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Title: Commonly asked questions about transcriptional activation domains
Eukaryotic transcription factors activate gene expression with their DNA-binding domains and activation domains. DNA- binding domains bind the genome by recognizing structurally related DNA sequences; they are structured, conserved, and predictable from protein sequences. Activation domains recruit chromatin modifiers, coactivator complexes, or basal tran- scriptional machinery via structurally diverse protein-protein interactions. Activation domains and DNA-binding domains have been called independent, modular units, but there are many departures from modularity, including interactions be- tween these regions and overlap in function. Compared to DNA-binding domains, activation domains are poorly under- stood because they are poorly conserved, intrinsically disor- dered, and difficult to predict from protein sequences. This review, organized around commonly asked questions, de- scribes recent progress that the field has made in under- standing the sequence features that control activation domains and predicting them from sequence.  more » « less
Award ID(s):
2112057
PAR ID:
10510794
Author(s) / Creator(s):
; ;
Publisher / Repository:
Current Opinion in Structural Biology
Date Published:
Journal Name:
Current Opinion in Structural Biology
Volume:
84
Issue:
C
ISSN:
0959-440X
Page Range / eLocation ID:
102732
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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