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Title: Strategies in engineering sustainable biochemical synthesis through microbial systems
Growing environmental concerns and the urgency to address climate change have increased demand for the development of sustainable alternatives to fossil-derived fuels and chemicals. Microbial systems, possessing inherent biosynthetic capabilities, present a promising approach for achieving this goal. This review discusses the coupling of systems and synthetic biology, to enable the elucidation and manipulation of microbial phenotypes for the production of chemicals that can substitute for petroleum-derived counterparts and contribute to advancing green biotechnology. The integration of artificial intelligence with metabolic engineering to facilitate precise and data-driven design of biosynthetic pathways is also discussed, along with the identification of current limitations and proposition of strategies for optimizing of biosystems, thereby propelling the field of chemical biology towards sustainable chemical production.  more » « less
Award ID(s):
2218259
PAR ID:
10527898
Author(s) / Creator(s):
;
Publisher / Repository:
Elsevier
Date Published:
Journal Name:
Current Opinion in Chemical Biology
Volume:
81
Issue:
C
ISSN:
1367-5931
Page Range / eLocation ID:
102493
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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